105184-37-0
中文名稱
L-精氨酰-L-賴氨酰-L-ALPHA-谷氨酰-L-纈氨酰-L-酪氨酸二醋酸鹽
英文名稱
ARG-LYS-GLU-VAL-TYR ACETATE SALT
CAS
105184-37-0
分子式
C33H55N9O11
分子量
753.84
MOL 文件
105184-37-0.mol
更新日期
2025/01/23 08:46:04
105184-37-0 結(jié)構(gòu)式
基本信息
中文別名
脾臟五肽醋酸脾臟五肽
L-精氨酰-L-賴氨酰-L-ALPHA-谷氨酰-L-纈氨酰-L-酪氨酸二醋酸鹽
英文別名
SP-5 ACETATE SALTSplenopentin diacetate
SPLENOPENTIN ACETATE SALT
ARG-LYS-GLU-VAL-TYR ACETATE
SP-5, Splenin Fragment 32-36
ARG-LYS-GLU-VAL-TYR ACETATE SALT
SPLENIN FRAGMENT 32-36 ACETATE SALT
ARG-LYS-GLU-VAL-TYR ACETATE SALT USP/EP/BP
SP-5, Splenin Fragment 32-36, Splenopentin
L-Arginyl-L-lysyl-L-alpha-glutamyl-L-valyl-L-tyrosine diacetate
所屬類別
生物化工：酪氨酸類衍生物常見問題列表
生物活性
Splenopentin diacetate 是一種合成的免疫調(diào)節(jié)性五肽，對應于脾臟激素脾臟蛋白的殘基 32-36。Splenopentin diacetate 可影響早期的 T 細胞和 B 細胞分化，從而增加 γ 射線照射后小鼠體內(nèi)抗體形成細胞的數(shù)量。體外研究
Splenopentin (1-100 μM) augments human NK cells and has no cytotoxicity.
Splenopentin (0.1 ng/mL-10 μg/mL; 3 h) induces phenotypic differentiation of both T- and B-cell precursor cells.
體內(nèi)研究
Splenopentin (1 mg/kg; i.p. three times a week for 7-90 d) accelerates Langerhans cell recruitment and leads to pretreatment levels of Langerhans cell (LC) density in the skin of mice.
Splenopentin (0.01-100 μg per mouse; i.p.) has no demonstrable effect on neuromuscular transmission of mice.
| Animal Model: | Female Balb/c/Bln mice were injected Cyclophosphamide or Dexamethasone for 5 consecutive days |
| Dosage: | 1 mg/kg |
| Administration: | I.p. three times a week for 7-90 days |
| Result: |
Reached the normal number of epidermal LCs at 28 days after the beginning of Cyclophosphamide treatment.
Accelerated restoration process and reached the normal LC density in the skin after 70 days in Dexamethasone treatment grops. |