107761-42-2
107761-42-2 結(jié)構(gòu)式
基本信息
BETA-淀粉樣蛋白-42
BETA-淀粉樣多肽-42
BETA-AMYLOID PEPTIDE (1-42), HUMAN
DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
AMYLOID B-PROTEIN FRAGMENT 1-42
Amyloidb-Peptide(1-42)(human)
H-Asp-Ala-Glu-Phe-Arg-His-Asp--Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-OH
H-asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Gly-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Ile-Ala-OH
Asp-Ala-Glu-Phe-Arg-His-Asp-Ser-Gly-Tyr-Glu-Val-His-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-Ile-Ala
SS-AMYLOID PEPTIDE (1-42), RAT
beta-Amyloid (1-42) human
L-alpha-Aspartyl-L-alanyl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-alpha-aspartyl-L-serylglycyl-L-tyrosyl-L-alpha-glutamyl-L-valyl-L-histidyl-L-histidyl-L-glutaminyl-L-lysyl-L-leucyl-L-valyl-L-phenylalanyl-L-phenylalanyl-L-alanyl-L-alpha-glutamyl-L-alpha-aspartyl-L-valylglycyl-L-seryl-L-asparaginyl-L-lysylglycyl-L-alanyl-L-isoleucyl-L-isoleucylglycyl-L-leucyl-L-methionyl-L-valylglycylglycyl-L-valyl-L-valyl-L-isoleucyl-L-alanine
M.W. 4514.08 C203H311N55O60S
物理化學(xué)性質(zhì)
常見(jiàn)問(wèn)題列表
大豆肽是大豆蛋白質(zhì)經(jīng)酸法或酶法水解或分離、精制而得到的多肽混合物，以小分子肽為主，還含有少量大分子肽、游離氨基酸、糖類和無(wú)機(jī)鹽等成份，分子質(zhì)量在5000u以下。大豆肽的蛋白質(zhì)含量為85%左右，其氨基酸組成與大豆蛋白質(zhì)相同，必須氨基酸的平衡良好，含量豐富。
大豆肽為白色至微黃色粉末，大豆肽具有無(wú)豆腥味、無(wú)蛋白變性、酸性不沉淀、加熱不凝固、易溶于水、流動(dòng)性好等良好的加工性能，是優(yōu)良的保健食品素材。
1、抗微生物，增加免疫
臨床試驗(yàn)表明，大豆肽可提高巨噬細(xì)胞的吞噬活性，促進(jìn)淋巴細(xì)胞的增殖，全面提高人體免疫力。
2、降血壓、降血脂
是通過(guò)抑制“血管緊張素轉(zhuǎn)換酶”，來(lái)達(dá)到降壓作用。降脂作用的主要機(jī)制可能與促使膽固醇代謝生成膽汁酸有關(guān)。
3、降血糖
大豆肽這種活性肽能及時(shí)補(bǔ)充體內(nèi)合成蛋白質(zhì)的營(yíng)養(yǎng)元素，減輕分泌胰島素的β胰島細(xì)胞的負(fù)擔(dān)，對(duì)β胰島細(xì)胞有很好的保護(hù)作用。
另外，它能防止糖尿病合并癥的發(fā)生，促進(jìn)糖尿病患者的機(jī)體康復(fù)。
4、消除疲勞
當(dāng)體內(nèi)消耗過(guò)多營(yíng)養(yǎng)物質(zhì)而感覺(jué)疲勞時(shí)，服用大豆多肽能恢復(fù)失調(diào)的內(nèi)環(huán)境，快速消除疲勞。
5、促進(jìn)礦物質(zhì)吸收
大豆肽能促進(jìn)多種礦物質(zhì)吸收，可與礦物質(zhì)結(jié)合，保護(hù)礦物質(zhì)，提高吸收率，預(yù)防和改善骨質(zhì)疏松、貧血等。
壓力大、體質(zhì)差、身心嚴(yán)重透支的白領(lǐng)人群
減肥人群，尤其是想塑身的人。
體質(zhì)弱的中老年人。
住院手術(shù)恢復(fù)慢的患者。
運(yùn)動(dòng)人群。
β-Amyloid Aggregation Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure.
2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80 ℃.
3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing.
4. Next, the solution was age 48h at 4-8 ℃. The sample was then centrifuged at 14000g for 10 min at 4-8 ℃; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments.
Methods vary depends on the downstream applications.
大豆肽是一類對(duì)生命活動(dòng)有益或具有生物功能活性的寡肽或多肽，具有多種生物活性，常作為功能性物質(zhì)添加在食品中。目前，食品生產(chǎn)過(guò)程中使用大豆蛋白作為原輔料加工的產(chǎn)品較多，而直接利用大豆活性肽生產(chǎn)的食品則較少，存在著缺乏相應(yīng)的生產(chǎn)使用標(biāo)準(zhǔn)、應(yīng)用范圍不是很廣泛、技術(shù)含量低等問(wèn)題。目前，急需優(yōu)化生產(chǎn)大豆活性肽的生產(chǎn)制備方法，提高大豆活性肽的生物活性，降低食品加工條件對(duì)大豆肽生物活性的影響，擴(kuò)大大豆活性肽在功能食品領(lǐng)域中的應(yīng)用和發(fā)展。