183745-81-5
中文名稱
183745-81-5
英文名稱
AMYLOID BETA-PROTEIN (1-15)
CAS
183745-81-5
分子式
C78H107N25O27
分子量
1826.86
MOL 文件
183745-81-5.mol
183745-81-5 結(jié)構(gòu)式
基本信息
中文別名
Β淀粉樣蛋白(1-15) 英文別名
Aβ1-15β-Amyloid 1-15
Amyloid β-Protein (1-15)
AMyloid b-Protein (1-15)
AMYLOID BETA-PROTEIN (1-15)
Amyloid beta-Protein (1-15) trifluoroacetate salt
H-ASP-ALA-GLU-PHE-ARG-HIS-ASP-SER-GLY-TYR-GLU-VAL-HIS-HIS-GLN-OH
L-Glutamine, L-α-aspartyl-L-alanyl-L-α-glutamyl-L-phenylalanyl-L-arginyl-L-histidyl-L-α-aspartyl-L-serylglycyl-L-tyrosyl-L-α-glutamyl-L-valyl-L-histidyl-L-histidyl-
物理化學(xué)性質(zhì)
密度1.59±0.1 g/cm3(Predicted)
儲(chǔ)存條件-20°C儲(chǔ)存
溶解度insoluble in EtOH; ≥182.6 mg/mL in DMSO; ≥50.7 mg/mL in H2O
形態(tài)固體
顏色White to off-white
常見(jiàn)問(wèn)題列表
生物活性
β-Amyloid (1-15) 是β-淀粉樣蛋白片段。 β-淀粉樣蛋白是在阿爾茨海默病患者的腦中形成淀粉樣斑塊的肽。靶點(diǎn)
Amyloid-β
體外研究
β-Amyloid (1-15) is produced by concerted β- and α-secretase cleavage of amyloid-β protein precursor (AβPP). β-Amyloid (1-15) seems to be a sensitive acute pharmacodynamic biomarker for γ-secretase inhibition and may have several advantages compared to measuring longer CSF Aβ species. .