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131602-53-4

中文名稱 BETA-淀粉樣蛋白片斷25-35
英文名稱 AMYLOID BETA-PROTEIN (HUMAN, 25-35) TRIFLUOROACETATE
CAS 131602-53-4
分子式 C45H81N13O14S
分子量 1060.27
MOL 文件 131602-53-4.mol
更新日期 2024/12/23 10:30:27
131602-53-4 結(jié)構(gòu)式 131602-53-4 結(jié)構(gòu)式

基本信息

中文別名
Β淀粉樣蛋白25-35
Β-淀粉狀蛋白25-35
Β-淀粉狀蛋白25-35
淀粉樣Β-蛋白片段25-35
Β-淀粉樣蛋白片段 25-35
Β-AMYLOID (25-35)
BETA-淀粉樣蛋白片斷25-35
BETA-類淀粉蛋白肽(25-35)
Β淀粉樣蛋白片斷25-35 三氟乙酸鹽
AMYLOID Β-PROTEIN FRAGMENT 25-35 Β-淀粉狀蛋白25-35
英文別名
Aβ25-35
GSNKGAIIGLM
BETA-AMYLOID
-Amyloid(25-35)
β-Amyloid (25-35)
BETA-AMYLOID (25-35)
β-Amyloid (25-35) TFA
25-35) TRIFLUOROACETATE
β-Amyloid peptide(25-35)
AMyloid b-Protein (25-35)
所屬類別
生物化工:多肽

物理化學(xué)性質(zhì)

沸點(diǎn)1517.3±65.0 °C(Predicted)
密度1.248±0.06 g/cm3(Predicted)
RTECS號BU7435200
儲存條件-20°C
溶解度insoluble in EtOH; insoluble in H2O; ≥106 mg/mL in DMSO
酸度系數(shù)(pKa)3.24±0.10(Predicted)
形態(tài)凍干。
顏色Lyophilized White
水溶解性易溶于水。
序列H-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-OH
InChIKeyWIHBNMPFWRHGDF-SLVFWPMISA-N

應(yīng)用領(lǐng)域

用途1
Amyloid β的功能區(qū)。兼具有神經(jīng)營養(yǎng)和神經(jīng)毒素效果。用于分子生物學(xué)研究。

安全數(shù)據(jù)

WGK Germany3
WGK Germany3
海關(guān)編碼2930909899
BETA-淀粉樣蛋白片斷25-35價(jià)格(試劑級)
報(bào)價(jià)日期產(chǎn)品編號產(chǎn)品名稱CAS號包裝價(jià)格
2024/11/11XW1316025342Β-淀粉狀蛋白25-35131602-53-41MG295元
2024/11/11XW1316025341Β-淀粉狀蛋白25-35131602-53-45MG878元
2024/11/08HY-P0128BETA-淀粉樣蛋白片斷25-35
β-Amyloid (25-35)
131602-53-41mg620元

常見問題列表

生物活性
β-Amyloid (25-35) (Amyloid beta-peptide (25-35)) 是阿爾茨海默氏淀粉樣蛋白β肽的Aβ(25-35) 片段,在培養(yǎng)細(xì)胞中顯示出神經(jīng)毒性活性。
體外研究

The amino acid sequence of Aβ(25-35) peptide is NH 2 -Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-COOH, where the first Gly represents the amino acid 25 and the last Met represents the amino acid 35. Amyloid beta-peptide(25-35) is also investigated in gel state for the first time. Comparative studies are also carried out using vibrational absorption and ECD. The conformational preference of Aβ(25-35) peptide film is also investigated using vibrational absorption and VCD spectroscopy. Amyloid beta-peptide(25-35) induces apoptotic effects on isolated brain mitochondria and the redox state of methionine-35, plays a key role in the induction of programmed cellular death pathways and toxic events.
β-Amyloid Aggregation Guidelines (Following is our recommended protocol. This protocol only provides a guideline, and should be modified according to your specific needs).
1. Solid Aβ peptide was dissolved in cold hexafluoro-2-propanol (HFIP). The peptide was incubated at room temperature for at least 1h to establish monomerization and randomization of structure.
2. The HFIP was removed by evaporation, and the resulting peptide was stored as a film at -20 or -80 ℃.
3. The resulting film was dissolved in anhydrous DMSO at 5 mM and then diluted into the appropriate concentration and buffer (serum- and phenol red-free culture medium) with vortexing.
4. Next, the solution was age 48h at 4-8 ℃. The sample was then centrifuged at 14000g for 10 min at 4-8 ℃; the soluble oligomers were in the supernatant. The supernatant was diluted 10-200-fold for experiments.
Methods vary depends on the downstream applications.

體內(nèi)研究

Rats are injected with Aβ25–35 peptide intracerebroventricularly and compound Danshen (CDS) are subsequently administered once daily for 23 days. Rats’ behavior is monitored using Morris water maze and passive avoidance. Real time PCR and Western blotting are used in determining amyloid precursor protein (APP), β-site APP cleaved enzyme-1(BACE1), Presenilin-1 (PS1), Insulin-degrading enzyme (IDE) and neprilysin (NEP) in hippocampus. The Alzheimer' s disease (AD) model group present with spatial learning and memory impairments. CDS and donepezil administration significantly ameliorate the Aβ25–35 peptide-induced memory impairment in both Morris water maze (P [3] .

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