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144409-98-3

中文名稱 BETA-淀粉樣肽(1-40)
英文名稱 AMYLOID BETA-PROTEIN (1-40) (MOUSE, RAT)
CAS 144409-98-3
分子式 C190H291N51O57S
更新日期 2024/11/01 22:01:38
144409-98-3 結(jié)構(gòu)式 144409-98-3 結(jié)構(gòu)式

基本信息

中文別名
大鼠淀粉樣Β蛋白1-40
Β淀粉樣肽(1-40)(鼠)
BETA-淀粉樣肽(1-40)
AMYLOID 尾-PEPTIDE (1-40) RAT
英文別名
-peptide (1-40) rat
β-Amyloid (1-40), rat
Rat amyloid β-protein 1-40
Rat aMyloid-β peptide 1-40
Rat aMyloid-beta peptide 1-40
Amyloid β-peptide (1-40) (rat)
Amyloid beta-peptide (1-40) (rat)
AMyloid b-Protein (1-40) (Mouse, rat)
Amyloidβ-Protein(1-40)(mouse,rat)/β-Amyloid(1-40),rat
H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH
所屬類別
生物:重組蛋白

物理化學性質(zhì)

儲存條件-15°C
溶解度Soluble to 1 mg/ml in 1% Ammonia
形態(tài)Solid
顏色White to off-white
序列H-Asp-Ala-Glu-Phe-Gly-His-Asp-Ser-Gly-Phe-Glu-Val-Arg-His-Gln-Lys-Leu-Val-Phe-Phe-Ala-Glu-Asp-Val-Gly-Ser-Asn-Lys-Gly-Ala-Ile-Ile-Gly-Leu-Met-Val-Gly-Gly-Val-Val-OH

常見問題列表

生物活性
Amyloid β-peptide (1-40) (rat) 是蛋白水解切割淀粉樣蛋白前體蛋白的易聚集產(chǎn)物,并且是在阿爾茨海默病腦中觀察到的老年斑的主要成分。
靶點

The Amyloid β-peptide (1-40) (rat)-treated rats require longer to find the platform hidden under the water. In the visible platform test, the latency for each group is similar (20.56±11.31 s in control and 14.68±9.97 s in Amyloid β-peptide (1-40) (rat) group, p=0.304). Among these tested proteins, 6 ones are significantly up-regulated and 7 ones significantly down-regulated in Amyloid β-peptide (1-40) (rat) group comparing with the control. Tubulin β chain is significantly down-regulated in Amyloid β-peptide (1-40) (rat) group (p=0.014) when compare with control. Similar changes are also observed for ATP synthase β subunit (p=0.010) and synapsin Ib between Amyloid β-peptide (1-40) (rat) and control groups, but not significantly for synapsin Ib (p=0.295).

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