| Identification | More | [Name]
SPDP | [CAS]
68181-17-9 | [Synonyms]
3-(2-PYRIDYLDITHIO)PROPIONIC ACID N-HYDROXY-SUCCINIMIDE ESTER
3-(2-PYRIDYLDITHIO)PROPIONIC ACID N-SUCCINIMIDYL ESTER
3-(2-PYRIDYLDITHIO)-PROPIONIC ACID-OSU
3-(PYRIDIN-2-YLDISULFANYL)-PROPIONIC ACID-OSU
N-SUCCINIMIDYL-3-(2-PYRIDYLDITHIO)PROPIONANATE
N-SUCCINIMIDYL 3-[2-PYRIDYLDITHIO]PROPIONATE
SPDP
SUCCINIMIDYL 3-(2-PYRIDYLDITHIO)PROPIONATE
succinimidyl3-(2-pyridyldithio)propionate(spdp)
1-[1-oxo-3-(2-pyridyldithio)propoxy]pyrrolidine-2,5-dione
3-(2-PYRIDYLDITHIO)PROPIONIC ACID*N-HYDR OXYSUCCINIM
2,5-Pyrrolidinedione, 1-1-oxo-3-(2-pyridinyldithio)propoxy-
3-(2-PYRIDYLDITHIO)-PROPIONIC ACID N-HYDROXYSUCCINIMIDE ESTER CRYSTALLINE
3-(Pyridin-2-yldisulfanyl)-propionic acid-OS
N-Succinimidyl 3-(2-pyridyldithio)propionate, SPDP
1-[1-Oxo-3-(2-pyridinyldithio)propyloxy]-2,5-pyrrolidinedione
3-(2-Pyridyldithio)propionic acid 2,5-dioxo-1-pyrrolidinyl ester
3-[(2-Pyridinyl)dithio]propionic acid succinimidyl ester
3-[(2-Pyridyl)dithio]propionic acid succinimidyl ester
N-[3-(2-Pyridyldithio)propionyloxy]succinimide | [EINECS(EC#)]
269-034-3 | [Molecular Formula]
C12H12N2O4S2 | [MDL Number]
MFCD00009636 | [Molecular Weight]
312.36 | [MOL File]
68181-17-9.mol |
| Chemical Properties | Back Directory | [Appearance]
White Solid | [Melting point ]
84-86 °C(lit.)
| [Boiling point ]
465.9±55.0 °C(Predicted) | [density ]
1.48±0.1 g/cm3(Predicted) | [storage temp. ]
−20°C
| [solubility ]
acetone: 50 mg/mL
| [form ]
powder
| [pka]
1.76±0.19(Predicted) | [color ]
White to Light Yellow | [Usage]
A heterobifunctional cross-linker | [BRN ]
1548137 | [Stability:]
Hygroscopic, Moisture Sensitive | [InChIKey]
JWDFQMWEFLOOED-UHFFFAOYSA-N | [CAS DataBase Reference]
68181-17-9(CAS DataBase Reference) |
| Safety Data | Back Directory | [Hazard Codes ]
Xi | [Risk Statements ]
R36/37/38:Irritating to eyes, respiratory system and skin . | [Safety Statements ]
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice .
S36:Wear suitable protective clothing . | [WGK Germany ]
3
| [F ]
1-10 | [HS Code ]
29333990 |
| Hazard Information | Back Directory | [Description]
SPDP NHS ester is a heterobiofunctional crosslinker which can react with amine and sulfhydryl groups. SPDP NHS esters are membrane permeable therefore allowing them to funtion inside of cells. | [Chemical Properties]
White Solid | [Uses]
A heterobifunctional cross-linker | [Uses]
Important crosslinking reagent for the preparation of protein-protein and peptide-protein conjugates linked by disulfide bonds. | [General Description]
3-(2-Pyridyldithio)propionic acid N-hydroxysuccinimide ester (SPDP) is a heterobifunctional cross-linking reagent with amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amines by amide bonds buffered at pH 7.5 (6.5-8.5). Second coupling specific for molecules containing free sulfhydryl by thiol-disulfide exchange buffered at pH 8.0 (7.5-8.5). Alternately, this reagent may be used as a protected thiolating reagent following initial coupling and reduction of linker. It incorporates four atom linker. |
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