| Identification | Back Directory | [Name]
SPDP-PEG4-acid | [CAS]
581065-97-6 | [Synonyms]
SPDP-PEG4-COOH
SPDP-PEG4-acid
SDPD-PEG4-COOH
Opss-peg(4)-cooh
Propanoic acid, 3-[[13-oxo-15-(2-pyridinyldithio)-3,6,9-trioxa-12-azapentadec-1-yl]oxy]- | [Molecular Formula]
C19H30N2O7S2 | [MDL Number]
MFCD13185000 | [MOL File]
581065-97-6.mol | [Molecular Weight]
462.581 |
| Chemical Properties | Back Directory | [Boiling point ]
677.3±55.0 °C(Predicted) | [density ]
1.27±0.1 g/cm3(Predicted) | [form ]
Liquid | [pka]
4.28±0.10(Predicted) | [color ]
Colorless to light yellow |
| Hazard Information | Back Directory | [Description]
SPDP-PEG4-acid is a PEG linker containing SPDP crosslinker and carboxylic acid moieties. SPDP is reactive toward thiol groups and contains a cleavable disulfide bond. Its membrane permeability allows for intracellular crosslinking reactions. The terminal caboxylic acid can react with primary amines in the presence of activators such as EDC and HATU to form stable amide bonds. The hydrophilic properties of the PEG linkers increase compound solubility in aqueous media. |
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