ChemicalBook CAS DataBase List N-Benzylglycine ethyl ester

N-Benzylglycine ethyl ester synthesis

12synthesis methods

Product Name:N-Benzylglycine ethyl ester
CAS Number:6436-90-4
Molecular formula:C11H15NO2
Molecular Weight:193.24

105-36-2 Synthesis

105-36-2
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$5.00/5 g

100-46-9 Synthesis

100-46-9
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$5.00/5 g

6436-90-4
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$8.00/10g

Yield:6436-90-4 97.7%

Reaction Conditions:

with N-benzyl-N,N,N-triethylammonium chloride;N-ethyl-N,N-diisopropylamine in dichloromethane at 20; for 4 h;

Steps:

2.1 Preparation of intermediate IV
To the 1000 mL three-necked flask was added 43 g (0.4 mol) of benzylamine,Dichloromethane 250 mL,45.6 g (0.2 mol) of benzyltriethylammonium chloride,(12.5%) of diisopropylethylamine (l.2 mol) was stirred at room temperature,A solution of 217.3 g (1.2 mol) of ethyl 2-bromoacetate and 150 mL of methylene chloride was added dropwise. After incubation at 25-28 ° C for 4 h, the reaction was complete and the reaction solution was cooled to 0-5 ° C And the filtrate was concentrated under reduced pressure to give 75.5 g (yield 97.7%) of light brown oil (Intermediate IV) and 98.4% by HPLC. The reaction was further carried out.

References:

Chongqing weipeng Pharmaceutical Co. Ltd.;Li, Nenggang;Zou, XiaoChuan;Shi, KaiYun;Gong, Xue;Zhou, XingGuo CN105622444, 2016, A Location in patent:Paragraph 0024; 0046-0047

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