ChemicalBook CAS DataBase List Glycine ethyl ester hydrochloride

Glycine ethyl ester hydrochloride synthesis

12synthesis methods

Product Name:Glycine ethyl ester hydrochloride
CAS Number:623-33-6
Molecular formula:C4H9NO2.ClH
Molecular Weight:139.58

A production method for glycine ethyl ester hydrochloride:First add dehydrated ethanol in 1# reactor, pass into anhydrous hydrogen chloride to obtain hydrochloric acid-ethanol solution; Add a certain amount of triethyl orthoformate and glycine and hydrochloric acid-ethanol solution in 2# reactor, in the Reaction under action; after the reaction is complete, distill and recover ethanol and ethyl formate; then add alcohol-ether mixture, wash, filter, concentrate, recrystallize, and vacuum dry to obtain ethyl glycine hydrochloride.

64-17-5 Synthesis

64-17-5
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56-40-6 Synthesis

56-40-6
1238 suppliers
$5.00/25g

623-33-6
641 suppliers
$5.00/10g

Yield:623-33-6 90.4%

Reaction Conditions:

with dichloro sulfoxide at -10 - 20; for 2 h;Heating / reflux;

Steps:

2.1.1 1. Glycine ethyl ester hydrochloride (Product 2)

247.3 g of thionyl chloride and 130 g of glycine were added at -10 C. to 1000 ml of ethanol. After removing the ice bath a further equivalent amount of glycine was added in portions. The mixture was then stirred for 2 hours under reflux. After cooling to room temperature the excess alcohol and the thionyl chloride were removed on a rotary evaporator. Ethanol was added twice more to the white solid obtained and the ethanol was in turn removed on the rotary evaporator in order completely to remove adhering thionyl chloride. After recrystallisation from ethanol 218.6 g (90.4% of theory) of the title compound (product 2) were obtained.

References:

US2003/236253,2003,A1 Location in patent:Page 12

56-40-6 Synthesis

56-40-6
1238 suppliers
$5.00/25g

623-33-6
641 suppliers
$5.00/10g

References

77385-90-1 Synthesis