Methylthiouracil synthesis
- Product Name:Methylthiouracil
- CAS Number:56-04-2
- Molecular formula:C5H6N2OS
- Molecular Weight:142.18
Yield:56-04-2 91%
Reaction Conditions:
with potassium hydroxide in ethanol at 80; for 5 h;
Steps:
1 Step 1:
To a vial was added ethyl 3-oxobutanoate (1 g, 8.0 mmol, 1 eq.), thiourea (0.6, 8.0 mmol, 1 eq.) and KOH (0.4 g, 8.0 mmol, 1 eq.) in ethanol (6 ml). The reaction mixture was stirred at 80° C. for 5 h. Ethanol was removed under reduced pressure to one third of its original volume, the reaction mixture was then poured into water and neutralized with 2 N HCl. The resulting mixture was left stirring overnight at rt. A precipitate formed and was filtered by vacuum filtration to provide the desired product 6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (1.0 g, 7.033 mmol, 91%) as white solid. ESI-MS: 143.2 [M+H]+.
References:
Purdue Research Foundation;Watts, Val J.;van Rijn, Richard M.;Flaherty, Daniel P.;Kaur, Jatinder US2019/23688, 2019, A1 Location in patent:Paragraph 0152
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![7-Methyl-5H-[1,3,4]thiadiazolo[3,2-a]pyrimidin-5-one](/CAS/20210111/GIF/35523-75-2.gif)
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