ChemicalBook CAS DataBase List Ethyl acetoacetate

Ethyl acetoacetate synthesis

12synthesis methods

Product Name:Ethyl acetoacetate
CAS Number:141-97-9
Molecular formula:C6H10O3
Molecular Weight:130.14

Ethyl acetoacetate is produced industrially by treatment of diketene with ethanol.
The preparation of ethyl acetoacetate is a classic laboratory procedure . It is prepared via the Claisen condensation of ethyl acetate. Two moles of ethyl acetate condense to form one mole each of ethyl acetoacetate and ethanol.

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64-17-5 Synthesis

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Yield:141-97-9 95%

Reaction Conditions:

with sulfuric acid at 85 - 125; for 6 h;

Steps:

1.1

1. 80 mol of concentrated sulfuric acid was added with 150mol absolute ethanol and is heated to 85°C then 100mol of diketene was added and stirred at 125 °C for 6h. The ethyl acetoacetate solution was obtained by distillation under reduced pressure, the yield was 95%, and the solution was directly put into the next reaction.

References:

CN105418422,2016,A Location in patent:Paragraph 0021; 0031