
Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate synthesis
- Product Name:Methyl 3-(3,5-di-tert-butyl-4-hydroxyphenyl)propionate
- CAS Number:6386-38-5
- Molecular formula:C18H28O3
- Molecular Weight:292.41

67-56-1
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20170-32-5
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6386-38-5
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Yield:6386-38-5 90%
Reaction Conditions:
with sulfuric acid for 16 h;Reflux;
Steps:
Typical procedure for synthesis of methyl esters
General procedure: According to a literature protocol.[1] Propanoic acid derivative (10 g) was dissolved inmethanol (80 ml) and H2SO4 (700μl, 6 mmol) added. The resulting solution was refluxed for16 h and then allowed to cool to room temperature. The reaction mixture was reduced todryness and re-dissolved in ethyl acetate (20 ml). The organic phase was washed withsaturated aqueous sodium hydrogen carbonate (10 ml), brine (10 ml) and dried over MgSO4.Removal of the solvent gave the desired methyl ester. (Note: column chromatography is oftennot required for the methyl ester starting materials).
References:
Jones, Kevin M.;Hillringhaus, Tim;Klussmann, Martin [Tetrahedron Letters,2013,vol. 54,# 25,p. 3294 - 3297] Location in patent:supporting information

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6386-38-5
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141-32-2
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128-39-2
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6386-38-5
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67-56-1
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6386-38-5
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$13.00/10g