ChemicalBook CAS DataBase List Methyl 3-(4-hydroxyphenyl)propionate

Methyl 3-(4-hydroxyphenyl)propionate synthesis

11synthesis methods

Product Name:Methyl 3-(4-hydroxyphenyl)propionate
CAS Number:5597-50-2
Molecular formula:C10H12O3
Molecular Weight:180.2

501-97-3 Synthesis

501-97-3
526 suppliers
$10.00/5g

74-88-4
348 suppliers
$15.00/10g

5597-50-2
229 suppliers
$5.00/1g

Yield:5597-50-2 95.9%

Reaction Conditions:

Stage #1:4-hydroxyphenylpropionic acid with potassium carbonate in N,N-dimethyl-formamide at 20; for 0.5 h;
Stage #2:methyl iodide in N,N-dimethyl-formamide at 0 - 20; for 3 h;

Steps:

1
Intermediate 2: Methyl 3-(4-hydroxyphenyl) propanoateTo a 1000 mL RB flask fitted with magnetic stirrer was charged 250 mL of DMF, 3-(4- Hydroxy-phenyl)-propanoic acid (25.0 g, 150.43 mmol) and K₂C0₃ (41.58 g, 300.87 mmol). The resulting mixture was stirred at RT for 30 minutes. Methyl Iodide (25.627 g, 180.51 mmol) was added to the resulting mixture which was precooled to 0 ?. The resulting mixture was stirred at RT for 3 h. After completion of the reaction (reaction monitored by TLC), the solvent was removed under reduced pressure and the crude mass was dissolved in ethyl acetate (250 mL). The organic layer was washed with water (250 mL), saturated sodium bicarbonate solution (250 mL X 2), and saturated brine solution (250 mL). The organic layer was dried over anhydrous Na₂S0₄ and the solvent was removed under reduced pressure. The product was obtained as yellow color oil (26 g, Yield: 95.9 %): MS (ESI, 120 eV) : m/z = 178.9 (M- H)⁺; ¹H NMR (300MHz, CDCI₃): δ 6.97-7.00(d, 2H), 6.66-6.69(d, 2H), 4.94(s, 1 H), 3.59(s, 3H), 2.78-2.83(t, 2H), 2.50-2.55(t, 2H).

References:

CONNEXIOS LIFE SCIENCES PVT. LTD.;RANGANATH RAO, Jagannath Madanahalli;ARUMUGAM, Nagarajan;ANSARI, Mohd Mudabbir;GUDLA, Chandrasekhar;PACHIYAPPAN, Shanmugam;RAMALINGAM, Manivannan;GEORGE, Jenson;ARUL, George Fernanda;BOMMEGOWDA, Y, Kenchegowda;ANGUPILLAI, Sathesh Kumar;KOTTAMALAI, Ramamoorthy;JIDUGU, Pradeep;RAO, D, Shivanageshwara WO2012/11125, 2012, A1 Location in patent:Page/Page column 59; 60

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3943-97-3 Synthesis