ChemicalBook CAS DataBase List 4-Hydroxycinnamic acid

4-Hydroxycinnamic acid synthesis

10synthesis methods

Product Name:4-Hydroxycinnamic acid
CAS Number:7400-08-0
Molecular formula:C9H8O3
Molecular Weight:164.16

141-82-2 Synthesis

141-82-2
748 suppliers
$5.00/25g

123-08-0 Synthesis

123-08-0
920 suppliers
$5.00/10g

7400-08-0
426 suppliers
$29.00/10g

Yield:7400-08-0 98%

Reaction Conditions:

with piperidine;pyridine for 1 h;Reflux;Knoevenagel-Doebner-Stobbe Reaction;

Steps:

2.1.1. General Method for Preparation of (E)-cinnamic Acids (16-23)

General procedure: The corresponding benzaldehyde derivative (24-31) (33mmol) and malonic acid (72 mmol) were dissolved in a mixture of 15 mL of pyridine and 0.25 mL of piperidine and heated under reflux until the end of the reaction, monitored by TLC. The reaction medium was cooled, neutralized with HCl (10% aq.), filtered in Buchner funnel, washed with water and dried, providing the appropriate (E)-cinnamic acids(16-23) as described next.

References:

Do Nascimento, Mayara S. S.;Camara, Vitória R. F.;da Costa, Juliana S.;Barbosa, Juliana M. C.;Lins, Alessandra S. M.;Salom?o, Kelly;de Castro, Solange L.;Carvalho, Samir A.;da Silva, Edson F.;Fraga, Carlos A. M. [Medicinal Chemistry,2020,vol. 16,# 6,p. 774 - 783]