ChemicalBook CAS DataBase List 4-Amino-2-chloropyridine

4-Amino-2-chloropyridine synthesis

11synthesis methods

Product Name:4-Amino-2-chloropyridine
CAS Number:14432-12-3
Molecular formula:C5H5ClN2
Molecular Weight:128.56

2-Chloro-4-aminopyridine is an intermediate of the plant growth regulator chlorfenuron, mainly in laboratory research and development and chemical production processes. It can be obtained by 2-chloropyridine-N-oxide as raw material, first nitrating with fuming nitric acid, and then reducing iron powder in acetic acid.

14432-16-7
214 suppliers
$10.00/1g

14432-12-3
537 suppliers
$5.00/5g

Yield:14432-12-3 85%

Reaction Conditions:

with hydrogenchloride;iron in ethanol;water;Reflux;

Steps:

1.3

(3) 2-chloro-4-nitropyridine N-oxide (7.9g, 0.05mol) in 500ml three-neck flask, iron powder (14g, 0.25mol), ethanol 150ml, water 50ml, 5ml of concentrated hydrochloric acid was heated to reflux , TLC to monitor the completion of the reaction, ethyl acetate was added until the reaction was complete 30ml, stirring was allowed to stand suction, delamination, dried over anhydrous sodium sulfate, and concentrated to give the product 2-chloro-4-aminopyridine, molar yield 85%

References:

CN109748865,2019,A Location in patent:Paragraph 0016; 0019; 0022

23056-36-2 Synthesis