ChemicalBook CAS DataBase List 3-Aminopyridine

3-Aminopyridine synthesis

15synthesis methods

Product Name:3-Aminopyridine
CAS Number:462-08-8
Molecular formula:C5H6N2
Molecular Weight:94.11

16013-85-7 Synthesis

16013-85-7
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$9.00/5g

462-08-8
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$14.00/25g

Yield:462-08-8 100 %Spectr.

Reaction Conditions:

with palladium 10% on activated carbon;hydrogen;sodium hydrogencarbonate in methanol at 20; under 760.051 Torr; for 2 h;Sealed tube;chemoselective reaction;

Steps:

General procedure forhydrodechlorination of 2-chloropyridine derivatives

General procedure: To a solution of the 2-chloropyridine derivative (1 equiv.) in MeOH (10 mL) was added 10% Pd/C (1 mol%) and NaHCO₃(1 equiv. per pyridine chlorine).The reaction vessel was sealed and flushed with hydrogen gas three times. The black suspension was stirred at room temperature under an atmosphere of hydrogen (1 atm.) for two hours. The mixture was filtered through celite washing with methanol and concentrated in vacuo. Purification by column chromatography was performed as required to yield the hydrodechlorinated pyridine product.

References:

Kinarivala, Nihar;Trippier, Paul C. [Tetrahedron Letters,2014,vol. 55,# 39,p. 5386 - 5389] Location in patent:supporting information