ChemicalBook CAS DataBase List Acetaminophen

Acetaminophen synthesis

14synthesis methods

Product Name:Acetaminophen
CAS Number:103-90-2
Molecular formula:C8H9NO2
Molecular Weight:151.16

Acetaminophen, p-acetaminophenol (3.2.80), is synthesized by reacting p-aminophenol with acetic anhydride [76,77].

108-24-7
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$14.00/250ML

123-30-8 Synthesis

123-30-8
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103-90-2
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$9.00/1g

Yield:103-90-2 99%

Reaction Conditions:

with silica gel for 0.5 h;Milling;Time;

Steps:

Paracetamol (6):

A 10 mL teflon jar was charged with 4-aminophenol (p-2c) (218.3 mg, 2.0 mmol) and silica (250mg). Acetic anhydride (Ac2O) was added using a pipette(204.2 mg, 189 μL, 2.0 mmol) and the mixture was milled at30 Hz for 30 minutes. The crude mixture was left in a fume hood to allow acetic acidto evaporate and was then suspended in 10 mL of methanol. After filtration andevaporation, paracetamol (6) was isolated. FTIR-ATR analysis confirmed that 6 wasidentical to the reference sample of paracetamol provided by Pliva TAPI. 298 mg(99%);

References:

Portada, Tomislav;Margeti?, Davor;?trukil, Vjekoslav [Molecules,2018,vol. 23,# 12,art. no. 3163] Location in patent:supporting information

99-93-4 Synthesis