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ChemicalBook >> CAS DataBase List >>4'-Hydroxyacetophenone

4'-Hydroxyacetophenone

CAS No.
99-93-4
Chemical Name:
4'-Hydroxyacetophenone
Synonyms
4-HYDROXYACETOPHENONE;Piceol;P-HYDROXYACETOPHENONE;POB;P-HYDROXYBENZOPHENONE;ACETYLPHENOL;p-Acetylphenol;4-Hydroksyacetofenol;4-HYDROXYLACETOPHENONE;para-Hydroxyacetophenone
CBNumber:
CB7198612
Molecular Formula:
C8H8O2
Molecular Weight:
136.15
MDL Number:
MFCD00002359
MOL File:
99-93-4.mol
MSDS File:
SDS
Last updated:2024-12-16 18:36:03

4'-Hydroxyacetophenone Properties

Melting point 132-135 °C(lit.)
Boiling point 147-148 °C3 mm Hg(lit.)
Density 1.109
vapor pressure 0.002Pa at 20℃
refractive index 1.5577 (estimate)
FEMA 4330 | 4-HYDROXYACETOPHENONE
Flash point 166 °C
storage temp. Store below +30°C.
solubility methanol: 0.1 g/mL, clear
form Crystalline Powder
pka 8.05(at 25℃)
color Almost white to beige
Specific Gravity 1.109
Odor at 10.00 % in dipropylene glycol. mild sweet hawthorn balsam mimosa
Odor Type floral
Water Solubility 10 g/L (22 ºC)
JECFA Number 2040
BRN 774355
InChIKey TXFPEBPIARQUIG-UHFFFAOYSA-N
LogP 1.35 at 25℃
Substances Added to Food (formerly EAFUS) 4-HYDROXYACETOPHENONE
CAS DataBase Reference 99-93-4(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII G1L3HT4CMH
NIST Chemistry Reference Acetophenone, 4'-hydroxy-(99-93-4)
EPA Substance Registry System 4-Hydroxyacetophenone (99-93-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H319-H412
Precautionary statements  P264-P273-P280-P305+P351+P338-P337+P313-P501
Hazard Codes  Xn,Xi
Risk Statements  36/37/38-22
Safety Statements  26-36/37-37/39-24/25-22-36
WGK Germany  3
RTECS  PC4959775
Hazard Note  Irritant
TSCA  Yes
HS Code  29145000
NFPA 704
1
2 0

4'-Hydroxyacetophenone price More Price(41)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich W433055 4-Hydroxyacetophenone ≥95%, FG 99-93-4 SAMPLE $50 2024-03-01 Buy
Sigma-Aldrich W433055 4-Hydroxyacetophenone ≥95%, FG 99-93-4 100G $150 2024-03-01 Buy
Sigma-Aldrich W433055 4-Hydroxyacetophenone ≥95%, FG 99-93-4 1KG $325 2024-03-01 Buy
Sigma-Aldrich PHR1971 Acetaminophen Impurity E Pharmaceutical Secondary Standard; Certified Reference Material 99-93-4 100MG $437 2024-03-01 Buy
Sigma-Aldrich PHL80232 4′-Hydroxyacetophenone phyproof? Reference Substance 99-93-4 100MG $262 2024-03-01 Buy
Product number Packaging Price Buy
W433055 SAMPLE $50 Buy
W433055 100G $150 Buy
W433055 1KG $325 Buy
PHR1971 100MG $437 Buy
PHL80232 100MG $262 Buy

4'-Hydroxyacetophenone Chemical Properties,Uses,Production

Chemical Properties

almost white to beige crystalline powder

Chemical Properties

White to beige powder; sweet, hawthorn, balsam, mimosa aroma

Occurrence

Reported found in cloudberry, coffee, cranberry, mango, sherry, and wort.

Uses

p-Hydroxyacetophenone is widely used in medicine, cosmetics and industrial fields. It is a natural plant extract, which naturally exists in the stems and leaves of the Compositae plant, Artemisia annua, the roots of plants such as Artemisia annua, Rhododendron, and Panax ginseng. It has a good effect on yellow eyes caused by diseases such as hepatitis, and also has a good auxiliary effect on yellow eyes caused by various reasons. Due to its weak molecular activity, high temperature resistance, melting point of 95-97 °C and boiling point of 296 °C, it is widely used in various liquid pharmaceuticals and can prolong the shelf life of other active ingredients under high temperature conditions. It has no harm to human skin and is the safest high-temperature auxiliary active stabilizer in the pharmaceutical industry.

Uses

4?-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions.

Uses

4′-Hydroxyacetophenone has been used as ketone component in the preparation of 1-aryl-3-phenethylamino-1-propanone hydrochlorides, potential cytotoxic agents, via Mannich reactions.

Application

4'-Hydroxyacetophenone has been suggested for use in perfume compositions as a modifier for the more conventional derivatives of Acetophenonc, etc. mainly in heavy-floral or woodyfloral fragrances where power and low cost arc requested.

Production Methods

4'-Hydroxyacetophenone can be produced 1) from Phenylacetate by heating with Aluminum chloride. 2) from Phenol, Acetylchlonde and Aluminum chloride by Friedel-Craft' reaction.

Preparation

Preparation by Fries rearrangement of phenyl acetate with Lewis acids
aluminium chloride
in nitrobenzene at 20–25° or at 50–60°
in chlorobenzene between 45° and 65°, sealed tube and subjected to high power microwave irradiation for 2 min only (36%)
in nitroethane at 60° (44%)
in carbon disulfide at 45° (40%)
in petroleum ether at 50° (20%)
but between 130° and 175° (40–60%)
aluminium chloride–sodium chloride mixture at 240–250° (10%)
boron trifluoride at 90° (56%)
scandium tris(trifluoromethanesulfonate), in nitromethane, at 50° (39%)
titanium tetrachloride at 90–100° (34%)
ferric chloride at 65° (25%)
zinc chloride at 125° (8%)
hydrofluoric acid, between 20° and 100° (94%)
polyphosphoric acid, between 20° and 100° (69%) (50–53%)(44%)
Nafion-XR 500, sulfonic acid type at 100°
ZSM-5, in sulfolane, at 180° (28%)
H-ZSM-5 at 400° or at 210° (6%)
H-Nu-2 at 170° (15%)
HY (Si/Al = 3) or fluorided alumina (Al2O3-F; 3 % wt. F), at 400°.

Definition

ChEBI: A monohydroxyacetophenone carrying a hydroxy substituent at position 4'.

Aroma threshold values

Floral type, medium strength odor; recommend smelling in a 10.00% solution or less.

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 5829, 1991 DOI: 10.1016/S0040-4039(00)93567-6

General Description

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Flammability and Explosibility

Non flammable

Purification Methods

Crystallise it from diethyl ether, aqueous EtOH or *benzene/pet ether. [Beilstein 8 H 87, 8 IV 339.]

155853-28-4
99-93-4
Synthesis of 4'-Hydroxyacetophenone from Phenol, 4-(2-methyl-1,3-dithian-2-yl)-
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View Lastest Price from 4'-Hydroxyacetophenone manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
4'-Hydroxyacetophenone pictures 2024-12-17 4'-Hydroxyacetophenone
99-93-4
 US $45.00 / kg 1kg 99% 20ton Hebei Zhuanglai Chemical Trading Co.,Ltd
4'-Hydroxyacetophenone pictures 2024-12-17 4'-Hydroxyacetophenone
99-93-4
 US $8.90 / kg 1kg 99 100tons HANGZHOU HAILAN CHEMICAL CO.,LTD.
4'-Hydroxyacetophenone pictures 2024-12-17 4'-Hydroxyacetophenone
99-93-4
 US $6.00 / KG 1KG 99% 20TONS Hebei Longbang Technology Co., Ltd
1-(4-hydroxyphenyl)-ethanon Hydroxyacetophenone, para HYDROXYACETOPHENONE-4 HYDROXYBENZOPHENONE-4 AKOS BBS-00003226 4-ACETOPHENOL 4-BENZOYLPHENOL 4'-HYDROXYACETOPHENONE 4-HYDROXYPHENYL METHYL KETONE 4'-Hydroxyacetophenone 4-Acetylphenol 4-HydraxyAcetophenone 4-HYDROXY ACETOPHENONE (p-HYDROXY ACETOPHENONE) 4'-Hydroxyacetophenone,99% PARA-METHYLKETOPHENOL PARA-ACETYLPHENOL Acetophenone,4'-hydroxy- D-Hydroxyacetophehone 4''-HYDROXYACETOPHENONESALBUTAMOL 4'-Hydroxyacetophenone,98% Methyl p-hydroxyphenyl ketone methyl-p-hydroxyphenylketone Phenol, p-acetyl- p-hydroxy-acetophenon p-Hydroxyphenyl methyl ketone p-hydroxyphenylmethylketone p-Oxyacetophenone USAF kf-15 usafkf-15 P-BENZOYLPHENOL P-ACETOPHENOL 1-(4-hydroxyphenyl)-1-ethanone HYDROXYACETOPHENONE, P- (RG) 4'-Hydroxyacetophene 4'-Hydroxyacetopheno Methyl 4-Hydroxyphenyl Ketone NSC 3698 p-Hydoxyacetophenone 4-Acetophenol 4-Acetylphenol 4-Hydroxyphenyl Methyl Ketone 4'-HYDROXYACETOPHENONE FOR SYNTHESIS Acetophenone, 4'-hydroxy- (6CI,8CI) Acetophenone, p-hydroxy- (3CI) ParacetaMol IMpurity E 1-(4-Hydroxyphenyl)ethan-1-one, 4-Acetylphenol The hydroxy acetophenone 4'-Hydroxyacetophenone> 1-(4-Hydroxyphenyl)ethanone (4-Hydr Paracetamol(Acetaminophen) EP Impurity E P-Hydroxy acetophenone -99% Factory supply 4'-Hydroxyacetophenone CAS 99-93-4 high quality Acetaminophen impurities1459 Acetaminophen EP Impurity E p-Hydroxy acetophenone, 98%+ Hydroxyce Tophenone Acetaminophen Impurity E 2,5-dimethyl-1H-pyrazolo[1,5-a]pyrimidin-7-one Paracetamol EP Impurity E (4'-Hydroxyacetophenone) 4'-Hydroxyacetophenone IN STOCK 4'-Hydroxyacetophenone factory China