2-Chloro-4-nitropyridine synthesis
- Product Name:2-Chloro-4-nitropyridine
- CAS Number:23056-36-2
- Molecular formula:C5H3ClN2O2
- Molecular Weight:158.54
14432-16-7
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23056-36-2
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Yield:23056-36-2 78%
Reaction Conditions:
with phosphorus trichloride in chloroform at 20;Heating / reflux;
Steps:
17
Reference Example 17: 2-Chloro-4-nitro-pyridine. Phosphorus trichloride (4.2 mL, 48.7 mmol) was-added_to a solution of 2- chloro-4-nitro-pyridine-l -oxide (1.70 g, 9.74 mmol) in dry chloroform (25 mL) at r.t.The reaction mixture was then heated to reflux and maintained at this temperature overnight. The reaction was cooled to r.t. then poured onto ice, basified to between pH7-8 with saturated aq. sodium bicarbonate solution and extracted with chloroform (x 2).The combined organic phase was washed with water and brine, dried over sodium sulfate and concentrated. Drying under high vacuum afforded 2-chloro-4-nitro-pyridine(1.2 g, 78 %) as a solid.
References:
F2G LTD WO2008/62182, 2008, A1 Location in patent:Page/Page column 114
109-09-1
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23056-36-2
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$6.00/1g
2402-95-1
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23056-36-2
378 suppliers
$6.00/1g