2-Chloropyridine-N-oxide synthesis
- Product Name:2-Chloropyridine-N-oxide
- CAS Number:2402-95-1
- Molecular formula:C5H4ClNO
- Molecular Weight:129.54
109-09-1
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$10.60/1gm:
2402-95-1
178 suppliers
$55.00/1g
Yield:2402-95-1 98.88%
Reaction Conditions:
with dihydrogen peroxide in water at 65 - 80; for 1 h;Reagent/catalyst;
Steps:
2 Example 2
A 1000 ml four-necked flask was charged with 200 g of 2-chloropyridine, 200 g of deionized water and 6 g of a TS-1 molecular sieve catalyst,Stir to raise the temperature to 65 , 15min dropwise 200g hydrogen peroxide (30% of the mass fraction), dropping at the same time control the reaction bottleThe temperature is maintained at 70 ~ 80 , after the drop of 75 insulation reaction 1h reaction end, cooling to 45 filter, filter cake after drainingAdd 20g deionized water to wash twice, the catalyst filter cake applied to the next reaction, washing water into the filtrate to be 2-chloropyridine nitrogenThe mass was 641 g, the oxide content was 35.02%, and the yield was 98.88%.
References:
Jiangsu Zhongbang Pharmaceutical Co., Ltd.;Xue, Yi;Ding, Yongshan;Zhan, Xinhua;Xu, Qiang;Li, Weisi;Zhao, Huayang CN106588762, 2017, A Location in patent:Paragraph 0043; 0044; 0049
14150-95-9
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$30.00/100mg
2402-95-1
178 suppliers
$55.00/1g
