ChemicalBook CAS DataBase List 4-Amino-2-chlorobenzoic acid

4-Amino-2-chlorobenzoic acid synthesis

7synthesis methods

Product Name:4-Amino-2-chlorobenzoic acid
CAS Number:2457-76-3
Molecular formula:C7H6ClNO2
Molecular Weight:171.58

99-60-5
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$19.10/100g

2457-76-3
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$5.00/1g

Yield:2457-76-3 88%

Reaction Conditions:

with isopropyl alcohol;potassium hydroxide at 20; for 2.5 h;Catalytic behavior;

Steps:

General procedure for the reduction in nitroarenes
First, NaBH4 (1 mmol) was used as a reducing agent forthe conversion of Ag (+ 1) to Ag (0) in methanol at roomtemperature for 2 h. After that, the Ag/MMT was filtered andused as a catalyst. Then, in a typical procedure, a mixtureof 4-nitrophenol (0.1 mmol), KOH (0.15 mmol), isopropylalcohol (3 mL), and Ag/MMT catalyst (50 mg) 1.01 wt%was stirred at room temperature for an appropriate time(Scheme 2). After the completion of the reaction (monitoredby GC), the catalyst was separated by filtration. The ensuingproduct was extracted with ethyl acetate and repeatedlywashed with water (3-4 times) to remove KOH. The resultingsolvent was evaporated to dryness in vacuum.

References:

Karami, Kazem;Rahimi, Mahzad;Dinari, Mohammad [Journal of the Iranian Chemical Society,2018,vol. 15,# 2,p. 281 - 291]

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