ChemicalBook CAS DataBase List 2,5-Dimethylpyridine

2,5-Dimethylpyridine synthesis

13synthesis methods

Product Name:2,5-Dimethylpyridine
CAS Number:589-93-5
Molecular formula:C7H9N
Molecular Weight:107.15

71-23-8 Synthesis

71-23-8
765 suppliers
$12.00/100g

108-99-6
328 suppliers
$9.00/5g

589-93-5
132 suppliers
$32.00/5mL

Yield:589-93-5 84%

Reaction Conditions:

with Raneynickel at 180; for 0.5 h;Flow reactor;Green chemistry;regioselective reaction;Concentration;

Steps:

3.2. General Flow Procedure for the Synthesis of 2-Methylpyridines
General procedure: The continuous flow system was set up as described in Figure 1 by using either a Waters 515 pump or Vapourtec R2 pumping module to progress 1-propanol through a stainless steel column (150 × 4.6 mm) packed with 5.5 g of Raney nickel. Initially, while a 0.05 M solution of the respective pyridine was prepared in 5 mL of 1-propanol, the flow rate was set to 0.3 mL/min and the catalyst column was heated in a sand bath to >180 °C for 30 min. The flow rate was then set to 0.1 mL/min and the sample was placed in a 5 mL sample loop and introduced into the reaction stream. The dead volume had been estimated at ~1 mL (~2.5 mL max theoretical, 150 × 4.6mm cylinder) giving a ~10 min residence time: however, the sample was collected for 30 min to ensure complete collection. The solvent was evaporated to yield a product that was of sufficient purity for further use.

References:

Manansala, Camille;Tranmer, Geoffrey K. [Molecules,2015,vol. 20,# 9,p. 15797 - 15806]

FullText