益母草堿|T5S2102

價(jià)格	￥108	￥139	￥213
包裝	1mg	2mg	5mg

最小起訂量	1mg
發(fā)貨地	上海
更新日期	2024-12-02

QQ交談微信洽談

產(chǎn)品詳情

中文名稱:益母草堿	英文名稱:Leonurine
CAS:24697-74-3	品牌: TargetMol
產(chǎn)地: 美國(guó)	保存條件: Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
純度規(guī)格: 98.55%	產(chǎn)品類別: 抑制劑
貨號(hào): T5S2102

Product Introduction

Bioactivity

名稱	Leonurine
描述	Leonurine (SCM-198) is an alkaloid that has been found in H. leonuri and with anti-oxidative and anti-inflammatory.
細(xì)胞實(shí)驗(yàn)	Human THP-1 cells were fully differentiated into foam cells by the pre-treatment with phorbol-12-myristate-13-acetate (PMA) and oxidized density lipoproteins (ox-LDL). After cells were incubated with various concentrations of leonurine, Oil Red O staining and high-performance liquid chromatography (HPLC) assays were utilized to detect cellular lipid accumulation and cholesterol content, respectively. Cellular cholesterol efflux was determined by liquid scintillation counting. The mRNA and protein levels of ATP-binding cassette transporter A1/G1 (ABCA1/G1), peroxisome proliferator-activated receptor γ (PPARγ) and liver X receptor α (LXRα) in foam cells were assessed using real-time quantitative PCR (RT-qPCR) and western blot analyses, respectively. Plasma triglyceride (TG), total cholesterol (TC), high-density lipoprotein-cholesterol (HDL-C) and low-density lipoprotein-cholesterol (LDL-C) levels in apoE-/- mice were evaluated using enzymatic methods. The atherosclerotic lesion sizes and collagen contents in aortic roots were determined by Oil Red O and Masson's trichrome staining, respectively[1].
動(dòng)物實(shí)驗(yàn)	Used the chronic mild stress mouse model to explore the antidepressant effects of leonurine and the potential mechanisms. Behavioral tests including sucrose preference test, forced swimming test, and tail suspension test were taken to evaluate depression symptoms. Moreover, the contents of monoamine neurotransmitters in hippocampus and prefrontal cortex were measured by high-performance liquid chromatography. Neuronal morphology was detected by transmission electron microscopy[2].
體外活性	Leonurine 顯著抑制人類THP-1巨噬細(xì)胞衍生泡沫細(xì)胞中的脂質(zhì)積累，并以濃度依賴的方式促進(jìn)了3H-膽固醇外流。此外，ABCA1/G1、PPARγ和LXRα的mRNA和蛋白水平均被Leonurine提升，而這一效果被LXRα siRNA或PPARγ siRNA轉(zhuǎn)染所減弱[1]。
體內(nèi)活性	連續(xù)給藥leonurine（60 mg/kg）4周顯著緩解慢性輕度應(yīng)激小鼠的抑郁樣行為，包括提高蔗糖偏好度和在強(qiáng)迫游泳測(cè)試及尾懸掛測(cè)試中減少不動(dòng)時(shí)間。進(jìn)一步研究發(fā)現(xiàn)，leonurine（60 mg/kg）有效恢復(fù)慢性輕度應(yīng)激小鼠海馬和前額葉皮層中5-羥色胺、去甲腎上腺素和多巴胺的水平，并伴隨海馬神經(jīng)元損傷的改善。此外，leonurine（60 mg/kg）顯著抑制了慢性輕度應(yīng)激小鼠體內(nèi)促炎細(xì)胞因子白細(xì)胞介素-1β、白細(xì)胞介素-6和TNF-α的產(chǎn)生，并抑制了核因子kappa B信號(hào)通路[2]。
存儲(chǔ)條件	Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
溶解度	DMSO : ＜1 mg/mL (insoluble or slightly soluble)
關(guān)鍵字	Autophagy \| inhibit \| Leonurine \| SCM198 \| Inhibitor \| SCM 198
相關(guān)產(chǎn)品	Guanidine hydrochloride \| Naringin \| Valproic Acid \| Taurine \| Gefitinib \| Aceglutamide \| Hydroxychloroquine \| Curcumin \| Stavudine \| Salicylic acid \| Paeonol \| Sodium 4-phenylbutyrate
相關(guān)庫	經(jīng)典已知活性庫 \| 植物來源化合物庫 \| 已知活性化合物庫 \| 生物堿類天然產(chǎn)物庫 \| 藥食同源庫 \| 抗癌天然產(chǎn)物庫 \| 中藥單體化合物庫 \| 天然產(chǎn)物庫 \| 中藥抗炎分子庫 \| 高通量篩選天然產(chǎn)物庫

關(guān)鍵字：益母草堿|||鹽酸益母草堿|||SCM-198|TargetMol

公司簡(jiǎn)介

上海陶術(shù)生物科技有限公司為美國(guó)Target Molecule Corp. ( Target Mol ) 在上海建立的全資子公司。我們與美國(guó)波士頓、德國(guó)慕尼黑的同事一起，為北美、歐洲和亞洲從事藥物研發(fā)和生物學(xué)研究的科學(xué)家提供優(yōu)質(zhì)的產(chǎn)品和專業(yè)的服務(wù)。公司下設(shè)篩選事業(yè)部，化學(xué)事業(yè)部，生物事業(yè)部和新材料部。從虛擬篩選到實(shí)體化合物分子供應(yīng)；從商業(yè)化產(chǎn)品銷售到個(gè)性化定制合成；從對(duì)明確靶點(diǎn)的分子篩選到對(duì)明確分子的多靶點(diǎn)篩選，從高通量篩選到化學(xué)結(jié)構(gòu)優(yōu)化，我們都可以滿足您的科研用品及技術(shù)服務(wù)的需求。經(jīng)過在中國(guó)市場(chǎng)五年的精心耕耘，我們已成為篩選化合物領(lǐng)域優(yōu)秀的供應(yīng)商，為超過五百家學(xué)校和各類企業(yè)提供了品質(zhì)卓越的小分子化合物和藥物篩

成立日期	2013-04-18 （12年）	注冊(cè)資本	566.2651萬人民幣
員工人數(shù)	100-500人	年?duì)I業(yè)額	￥ 1億以上
主營(yíng)行業(yè)	化學(xué)試劑,生物活性小分子	經(jīng)營(yíng)模式	貿(mào)易,試劑,定制,服務(wù)

TargetMol中國(guó)（陶術(shù)生物）

VIP 12年

公司成立：12年
注冊(cè)資本：566.2651萬人民幣
企業(yè)類型：有限責(zé)任公司(自然人投資或控股)
主營(yíng)產(chǎn)品：小分子抑制劑，藥物篩選化合物庫，天然產(chǎn)物，活性分子化合物等
公司地址：上海市閘北區(qū)江場(chǎng)三路28號(hào)4樓

進(jìn)入店鋪

詢盤

店內(nèi)推薦

白藜蘆醇三甲醚|T3330

￥150

知母皂苷 A-III|T3395

￥248

獨(dú)活內(nèi)酯|TL0013

￥413