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24697-74-3

中文名稱(chēng) 鹽酸益母草堿
英文名稱(chēng) Leonurine hydrochloride
CAS 24697-74-3
分子式 C14H21N3O5
分子量 311.33
MOL 文件 24697-74-3.mol
更新日期 2024/12/24 09:18:40
24697-74-3 結(jié)構(gòu)式 24697-74-3 結(jié)構(gòu)式

基本信息

中文別名
益母草堿
益母草鹼
鹽酸益母草堿
益母草堿鹽酸鹽
鹽酸益母草堿一水合物
鹽酸益母草堿(標(biāo)準(zhǔn)品)
益母草堿, 來(lái)源于益母草
益母草堿鹽酸鹽,益母草堿
鹽酸益母草堿(益母草堿鹽酸鹽,益母草堿)
LEONURINE HYDROCHLORIDE 鹽酸益母草堿
英文別名
SCM-198
Leonurin
Leonurine
LEONURINE HCL
Leonurine (SCM-198)
leonurine hydrochloride
4-Guanidinobutyl syringate
4-Guanidino-1-butanol syringate
Leonurine hydrochloride USP/EP/BP
Leonurine Hydrochloride Monohydrate
所屬類(lèi)別
生物化工:中草藥成分

物理化學(xué)性質(zhì)

外觀性狀白色結(jié)晶粉末,可溶于甲醇、乙醇、DMSO等有機(jī)溶劑,來(lái)源于益母草。
熔點(diǎn)238 °C
沸點(diǎn)496.7±55.0 °C(Predicted)
密度1.29±0.1 g/cm3(Predicted)
儲(chǔ)存條件Keep in dark place,Inert atmosphere,2-8°C
溶解度DMSO:可溶,2mg/mL,澄清(加熱)
酸度系數(shù)(pKa)8.26±0.25(Predicted)
形態(tài)粉末
顏色白色至米色
穩(wěn)定性可在-20°C下的DMSO溶液保存長(zhǎng)達(dá)1個(gè)月。
InChIKeyWNGSUWLDMZFYNZ-UHFFFAOYSA-N

安全數(shù)據(jù)

危險(xiǎn)性符號(hào)(GHS)GHS hazard pictograms
GHS07
警示詞警告
危險(xiǎn)性描述H315-H319-H335
危險(xiǎn)品標(biāo)志Xi
危險(xiǎn)類(lèi)別碼36/37/38
安全說(shuō)明26-24/25
WGK Germany3
海關(guān)編碼29399990

應(yīng)用領(lǐng)域

用途1
用于含量測(cè)定/鑒定/藥理實(shí)驗(yàn)等
藥理藥效:1.對(duì)子宮的作用益母草堿對(duì)兔、貓、犬、豚鼠等多種動(dòng)物的子宮均呈興奮作用2.對(duì)循環(huán)系統(tǒng)的作用小劑量益母草堿對(duì)離體蛙心有增強(qiáng)收縮作用,使用大量時(shí)反呈抑制現(xiàn)象。這種抑制現(xiàn)象可能由于迷走神經(jīng)末梢興奮所致。
用途2
益母草堿具有活血、祛淤、調(diào)經(jīng)、消水的作用。
鹽酸益母草堿價(jià)格(試劑級(jí))
報(bào)價(jià)日期產(chǎn)品編號(hào)產(chǎn)品名稱(chēng)CAS號(hào)包裝價(jià)格
2024/11/11XW2473518002鹽酸益母草堿24697-74-3250MG220元
2024/11/08HY-N0741A鹽酸益母草堿
Leonurine hydrochloride
24697-74-310mM * 1mLin DMSO198元
2024/11/08HY-N0741A鹽酸益母草堿
Leonurine hydrochloride
24697-74-35mg650元

常見(jiàn)問(wèn)題列表

生物活性
Leonurine 是從 Herba leonuri 中分離到的生物堿,具有抗氧化、抗炎活性。
體外研究

Leonurine (0, 5, 10, 20, 40, 80 μM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ. Leonurine hydrochloride (LH) shows protective effect on cell viability of HepG2 and HL-7702 cells incubated with palmitic acid (PA) of free fatty acid (FFA) for 24?h. Leonurine hydrochloride (125, 250, 500?μM) improves cellular lipid accumulation in HepG2 and HL-7702 cells via activating AMPK/SREBP1 pathway. Leonurine (5, 10, 20?μM) inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6 in IL-1β-induced human chondrocytes, suppresses ECM degradation in human OA chondrocytes, and blocks IL-1β-induced PI3K and Akt phosphorylation in a dose-dependent manner.

體內(nèi)研究

Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice. Leonurine (20?mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model.

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