24697-74-3
基本信息
益母草鹼
鹽酸益母草堿
益母草堿鹽酸鹽
鹽酸益母草堿一水合物
鹽酸益母草堿(標(biāo)準(zhǔn)品)
益母草堿, 來(lái)源于益母草
益母草堿鹽酸鹽,益母草堿
鹽酸益母草堿(益母草堿鹽酸鹽,益母草堿)
LEONURINE HYDROCHLORIDE 鹽酸益母草堿
Leonurin
Leonurine
LEONURINE HCL
Leonurine (SCM-198)
leonurine hydrochloride
4-Guanidinobutyl syringate
4-Guanidino-1-butanol syringate
Leonurine hydrochloride USP/EP/BP
Leonurine Hydrochloride Monohydrate
物理化學(xué)性質(zhì)
安全數(shù)據(jù)
應(yīng)用領(lǐng)域
藥理藥效:1.對(duì)子宮的作用益母草堿對(duì)兔、貓、犬、豚鼠等多種動(dòng)物的子宮均呈興奮作用2.對(duì)循環(huán)系統(tǒng)的作用小劑量益母草堿對(duì)離體蛙心有增強(qiáng)收縮作用,使用大量時(shí)反呈抑制現(xiàn)象。這種抑制現(xiàn)象可能由于迷走神經(jīng)末梢興奮所致。
報(bào)價(jià)日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
2024/11/11 | XW2473518002 | 鹽酸益母草堿 | 24697-74-3 | 250MG | 220元 |
2024/11/08 | HY-N0741A | 鹽酸益母草堿 Leonurine hydrochloride | 24697-74-3 | 10mM * 1mLin DMSO | 198元 |
2024/11/08 | HY-N0741A | 鹽酸益母草堿 Leonurine hydrochloride | 24697-74-3 | 5mg | 650元 |
常見(jiàn)問(wèn)題列表
Leonurine (0, 5, 10, 20, 40, 80 μM) causes diminution in lipid accumulation, cellular cholesterol content, including total cholesterol (TC), free cholesterol (FC) and cholesteryl ester (CE), and increase in apoA-I- or HDL-mediated cholesterol efflux after treatment for 24 h. Leonurine also significantly and dose-dependently increases the expressions of ABCA1 and ABCG1 at the mRNA and protein levels in human THP-1 macrophages, and such effect is involved in PPARγ. Leonurine hydrochloride (LH) shows protective effect on cell viability of HepG2 and HL-7702 cells incubated with palmitic acid (PA) of free fatty acid (FFA) for 24?h. Leonurine hydrochloride (125, 250, 500?μM) improves cellular lipid accumulation in HepG2 and HL-7702 cells via activating AMPK/SREBP1 pathway. Leonurine (5, 10, 20?μM) inhibits the expression of iNOS, COX-2, PGE2, NO, TNF-α, and IL-6 in IL-1β-induced human chondrocytes, suppresses ECM degradation in human OA chondrocytes, and blocks IL-1β-induced PI3K and Akt phosphorylation in a dose-dependent manner.
Leonurine (10 mg/kg/d, p.o.) significantly increases the expressions of PPARγ, LXRα, ABCA1 and ABCG1, and decreases both TG and TC levels in serum of mice. Leonurine hydrochloride (50, 100, 200 mg/kg) improves intracellular lipid accumulation via activating AMPK/SREBP1 pathway, enhances biochemical parameters, reduces hepatic lipoperoxide and increases antioxidant levels in mice. Leonurine (20?mg/kg, p.o.) ameliorates osteoarthritis development in mouse DMM model.