產(chǎn)品屬性：
產(chǎn)品名稱(chēng) | 規(guī)格 | CAS號(hào) | 型號(hào) |
Eugenol | 20mg 100mg | 97-53-0 | EY-Y0165320 |
Cas No.97-53-0
別名
化學(xué)名 4-allyl-2-methoxyphenol
分子式 C10H12O2
分子量 164.2
溶解度 Soluble in DMSO
儲(chǔ)存條件 Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產(chǎn)品描述：
Eugenol, a phenylpropanoid class compounds, is a colourless to pale yellow oily liquid extracted from certain essential oils, such as clove oil, cinnamon, nutmeg, basil and bay leaf.
In vitro: Previous study showed that eugenol could deplete intracellular GSH, inhibit GJIC and ROS generation, and had a modest effect on MMP at concentrations of 10 to 100 μM. Eugenol at high concentrations was also able to affecte [Ca2+i, PMP, as well as nd pH. The earliest and most potent effects of either was found on GSH levels and GJIC. In addition, the coadministration of glutathione ethyl ester enhanced intracellular GSH levels by almost 100% and protected cells from cell death caused by eugenol completely. Such results indicated that eugenol exhibited its hepatotoxic effects mainly via depletion of cytoprotective thiols and disruptioin in thiol-dependent processes [1].
In vivo: Animal study showed that the pretreatment with a single dose of eugenol that was 1 h before indomethacin administration was fond to cause significant reductions in gastric acid outputs, gastric mucosal lesions, as well as pepsin activity with a obvioius increase in mucin concentration. In addition, eugenol could also attenuate the elevations in gastric mucosal malondialdehyde and total nitrite significantly [2].
Clinical trial: Clinical study has been conducted to evaluate the effects of zinc oxide eugenol and metapex in root canal treatment of primary teeth. Results showed that both zinc oxide eugenol and metapex had encouraging results, however, metapex could be more safely used whenever there was a doubt about the patient's follow-up return [3].
References:
[1] Thompson DC,Barhoumi R,Burghardt RC. Comparative toxicity of eugenol and its quinone methide metabolite in cultured liver cells using kinetic fluorescence bioassays. Toxicol Appl Pharmacol.1998 Mar;149(1):55-63.
[2] Morsy MA,Fouad AA. Mechanisms of gastroprotective effect of eugenol in indomethacin-induced ulcer in rats. Phytother Res.2008 Oct;22(10):1361-6.
[3] Gupta S,Das G. Clinical and radiographic evaluation of zinc oxide eugenol and metapex in root canal treatment of primary teeth. J Indian Soc Pedod Prev Dent.2011 Jul-Sep;29(3):222-8.
關(guān)鍵字： 97-53-0;C10H12O2;Eugenol;
上海一研生物科技有限公司Shanghai yiyan bio-technology Co. Ltd.主要從事免疫學(xué)、分子生物學(xué)和常規(guī)生化試劑等為一體的科研產(chǎn)品銷(xiāo)售企業(yè)，公司自成立以來(lái)，秉承""全心全意服務(wù)于科研工作者""的企業(yè)理念，立足生物科技領(lǐng)域，運(yùn)用生物技術(shù)和科研試劑，發(fā)展現(xiàn)代生物科技，為各類(lèi)大中小醫(yī)院及其它醫(yī)療機(jī)構(gòu)、高等院校、科研院所、企事業(yè)單位提供優(yōu)質(zhì)的產(chǎn)品，服務(wù)生物科技領(lǐng)域的科學(xué)研究人員。
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