21-羥基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯
用途生物活性體外研究 用途與合成方法 MSDS 21-羥基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯價(jià)格(試劑級(jí)) 上下游產(chǎn)品信息 專(zhuān)題
| 中文名稱(chēng) | 21-羥基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯 |
|---|---|
| 中文同義詞 | 21-羥基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯;醋酸四烯物;21-羥基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯 100G;醋酸四烯物(3TR);21-乙酰氧基孕甾-1,4,9(11),16-四烯-3,20-酮;16-四烯-3,20-二酮-21-醋酸酯;布地奈德雜質(zhì)對(duì)照品6;2-((8S,10S,13S,14S)-10,13-二甲基-3-氧代-6,7,8,10,12,13,14,15-八氫-3H-環(huán)戊二烯并[A]菲-17-基)-2-氧代乙基 乙酸酯 |
| 英文名稱(chēng) | 3,20-Dioxopregna-1,4,9(11),16-tetraen-21-yl acetate |
| 英文同義詞 | Pregna-1,4,9(11),16-tetraen-21-ol-3,20-dione 21-acetate;21-Acetoxypregna-1,4,9(11),16-tetrene-3,20-dione;3,20-Dioxopregna-1,4,9(11),16-tetrene-21-ol acetate;21-(Acetyloxy)-pregna-1,4,9(11),16-tetraene-3,20-dione;Pregna-1,4,9(11),16-tetraene-3,20-dione,21-(acetyloxy)-;Tetraen-acetic acid complex;3,20-dioxopregna-1,4,9(11),16-tetraen-21-yl acetate;[2-[(8S,10S,13S,14S)-10,13-dimethyl-3-oxo-6,7,8,12,14,15-hexahydrocyclopenta[a]phenanthren-17-yl]-2-oxoethyl] acetate |
| CAS號(hào) | 37413-91-5 |
| 分子式 | C23H26O4 |
| 分子量 | 366.45 |
| EINECS號(hào) | 253-497-3 |
| 相關(guān)類(lèi)別 | 化工產(chǎn)品-有機(jī)化工;添加劑1;雜質(zhì)對(duì)照品;原料藥;化工原料;原料中間體;Intermediates & Fine Chemicals;Pharmaceuticals;Steroids |
| Mol文件 | 37413-91-5.mol |
| 結(jié)構(gòu)式 |  |
21-羥基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯 性質(zhì)
| 熔點(diǎn) | 173-175°C |
|---|---|
| 沸點(diǎn) | 534.6±50.0 °C(Predicted) |
| 密度 | 1.21±0.1 g/cm3(Predicted) |
| 儲(chǔ)存條件 | Sealed in dry,2-8°C |
| 溶解度 | 二甲基亞砜：100 mg/mL（272.89 mM） |
| 形態(tài) | 固體 |
| 顏色 | 白色至類(lèi)白色 |
| InChI | InChI=1S/C23H26O4/c1-14(24)27-13-21(26)20-7-6-18-17-5-4-15-12-16(25)8-10-22(15,2)19(17)9-11-23(18,20)3/h7-10,12,17-18H,4-6,11,13H2,1-3H3/t17-,18-,22-,23-/m0/s1 |
| InChIKey | UFEOMHFPJREVTP-PTRHGPIFSA-N |
| SMILES | C1(=O)C=C2[C@](C)(C=C1)C1[C@]([H])([C@@]3([H])[C@@](CC=1)(C)C(C(=O)COC(C)=O)=CC3)CC2 |
醋酸四烯物(21-羥基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯,3TR)是合成曲安奈德、地塞米松、布地奈德等甾體藥物的重要中間體21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione 是 delta 9,11 類(lèi)固醇類(lèi)合成的中間體 (intermediate)，如 Vamorolone?(HY-109017)。delta 9,11 steroids 是糖皮質(zhì)激素的修飾后的產(chǎn)物，具有抗炎 (anti-inflammatory) 特性。delta 9,11 類(lèi)固醇類(lèi)可以用作保護(hù)細(xì)胞損傷(脂質(zhì)過(guò)氧化)和抑制新生血管的試劑。
Δ9,11 derivatives are designed and developed to stably incorporate into cell membranes and inhibit lipid peroxidation without glucocorticoid or mineralocorticoid activities, thus avoiding side effects associated with traditional corticosteroids. VBP15 acts as a lead compound due to potent NF-κB inhibition and GR translocation similar to prednisone and dexamethasone, lack of transactivation properties, and good bioavailability.
用途
地塞米松、倍他米松、確炎舒松的中間體。安全信息
| 更新日期 | 產(chǎn)品編號(hào) | 產(chǎn)品名稱(chēng) | CAS號(hào) | 包裝 | 價(jià)格 |
|---|---|---|---|---|---|
| 2024/11/08 | HY-136340 | 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione | 5 mg | 312元 | |
| 2024/11/08 | HY-136340 | 21-羥基孕甾-1,4,9(11),16-四烯-3,20-二酮-21-醋酸酯 21-Acetoxypregna-1,4,9(11),16-tetraene-3,20-dione | 37413-91-5 | 10mg | 500元 |