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ChemicalBook >> CAS DataBase List >> M348

M348

M348 price.
  • $32 - $870
  • Product name: M348
  • CAS: 899713-86-1
  • MF: C18H17ClF3N3O3
  • MW: 415.79
  • EINECS:809-791-4
  • MDL Number:MFCD05123530
  • Synonyms:M348;ML348;N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide;CS-2370;ML-348 (ML348);GNF-Pf-1127;ML 348;GNF-PF-1127;1-Piperazineacetamide, N-[2-chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-
21 prices
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  • AK Scientific
  • ApexBio Technology
  • Axon Medchem
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Sigma-Aldrich
  • Tocris
  • TRC
  • Usbiological
Package
  • 5mg
  • 10
  • 1mg
  • 50
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • ManufacturerAK Scientific
  • Product number0351CK
  • Product descriptionN-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-furoyl)piperazin-1-yl]acetamide
  • Packaging1mg
  • Price$145
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB4933
  • Product descriptionML348
  • Packaging50mg
  • Price$360
  • Updated2021-12-16
  • Buy
  • ManufacturerAxon Medchem
  • Product numberAxon2646
  • Product descriptionML348 99%
  • Packaging10mg
  • Price$104.5
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number18523
  • Product descriptionML348 ≥98%
  • Packaging1mg
  • Price$32
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18523
  • Product descriptionML348 ≥98%
  • Packaging5mg
  • Price$100
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18523
  • Product descriptionML348 ≥98%
  • Packaging10mg
  • Price$184
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number18523
  • Product descriptionML348 ≥98%
  • Packaging25mg
  • Price$343
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5993
  • Product descriptionML348 99.88%
  • Packaging5mg
  • Price$72
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5993
  • Product descriptionML348 99.88%
  • Packaging10mg
  • Price$120
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5993
  • Product descriptionML348 99.88%
  • Packaging25mg
  • Price$264
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5993
  • Product descriptionML348 99.88%
  • Packaging50mg
  • Price$456
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-5993
  • Product descriptionML348 99.88%
  • Packaging100mg
  • Price$804
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC9874
  • Product descriptionML-348(ML348) >98%
  • Packaging250mg
  • Price$850
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC9874
  • Product descriptionML-348(ML348) >98%
  • Packaging100mg
  • Price$500
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML1901
  • Product descriptionML348 ≥98% (HPLC)
  • Packaging25MG
  • Price$424
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberSML1901
  • Product descriptionML348 ≥98% (HPLC)
  • Packaging5MG
  • Price$105
  • Updated2024-03-01
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 0351CK N-[2-Chloro-5-(trifluoromethyl)phenyl]-2-[4-(2-furoyl)piperazin-1-yl]acetamide 1mg $145 2021-12-16 Buy
ApexBio Technology B4933 ML348 50mg $360 2021-12-16 Buy
Axon Medchem Axon2646 ML348 99% 10mg $104.5 2021-12-16 Buy
Cayman Chemical 18523 ML348 ≥98% 1mg $32 2024-03-01 Buy
Cayman Chemical 18523 ML348 ≥98% 5mg $100 2024-03-01 Buy
Cayman Chemical 18523 ML348 ≥98% 10mg $184 2024-03-01 Buy
Cayman Chemical 18523 ML348 ≥98% 25mg $343 2024-03-01 Buy
ChemScene CS-5993 ML348 99.88% 5mg $72 2021-12-16 Buy
ChemScene CS-5993 ML348 99.88% 10mg $120 2021-12-16 Buy
ChemScene CS-5993 ML348 99.88% 25mg $264 2021-12-16 Buy
ChemScene CS-5993 ML348 99.88% 50mg $456 2021-12-16 Buy
ChemScene CS-5993 ML348 99.88% 100mg $804 2021-12-16 Buy
DC Chemicals DC9874 ML-348(ML348) >98% 250mg $850 2021-12-16 Buy
DC Chemicals DC9874 ML-348(ML348) >98% 100mg $500 2021-12-16 Buy
Sigma-Aldrich SML1901 ML348 ≥98% (HPLC) 25MG $424 2024-03-01 Buy
Sigma-Aldrich SML1901 ML348 ≥98% (HPLC) 5MG $105 2024-03-01 Buy

Properties

Boiling point :546.2±50.0 °C(Predicted)
Density :1.422±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO : 25 mg/mL (60.13 mM; Need ultrasonic)
form :Powder
pka :13.13±0.70(Predicted)
color :White to off-white

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H301 Toxic if swalloed Acute toxicity,oral Category 3 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
Precautionary statements:
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P321 Specific treatment (see … on this label).
P330 Rinse mouth.
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Lysophospholipase 1 (LYPLA1) is a protein palmitoyl thioesterase responsible for depalmitoylation of the oncogene HRas. Palmitoylation of such oncogenes is thought to be required for trafficking and malignant transformation, making LYPLA1 a target for downregulating oncogenic signaling. ML348 is a reversible LYPLA1 inhibitor with an IC50 value of 210 nM. It is 14-fold selective for LYPLA1 over LYPLA2 (IC50 = >3,000) and demonstrates little activity against a panel of more than 20 other serine hydrolases (IC50s = >10,000).

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