Selective and in vivo active inhibitor for acyl-protein thioesterase APT1 (IC50 values 0.84 µM and >10 µM for APT1 and APT2, respectively; Ki values 280 nM and >10000 nM for WT APT1 and APT2, respectively). A useful tool to study LYPLA/APT mediated protein S-palmitoylation and related pharmacology. In some of the literature, APT1 and APT2 are also identified as lysophospholipases LYPLA1 and LYPLA2 as they were first discovered due to their ability to hydrolyze various lysophospholipids.

KEYWORDS: ML348 | supplier | APT1 inhibitor | ML-348 | CAS [899713-86-1] | S-palmitoylated proteins | APT | acyl-protein thioesterase | LYPLA | APT2 | LYPLA1 | LYPLA2 | lysophospholipids