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ML-348(ML348)

  Cat. No.:  DC9874   Featured
Chemical Structure
899713-86-1
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More than 5000 active chemicals with high quality for research!
Field of application
ML 348(ML348) is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM).
Cas No.: 899713-86-1
Chemical Name: N-[2-Chloro-5-(trifluoromethyl)phenyl]-4-(2-furanylcarbonyl)-1-piperazineacetamide
Synonyms: ML 348
SMILES: N(CC(NC1=CC(C(F)(F)F)=CC=C1Cl)=O)1CCN(C(C2=CC=CO2)=O)CC1
Formula: C18H17ClF3N3O3
M.Wt: 415.79
Description: ML348 is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM), Exhibits 14-fold selectivity for LYPLA1 over LYPLA2, Also selective over a panel of ~30 other serine hydrolases.target: LYPLA1 [1]IC 50： 210 nM [1]
MSDS
COA
LOT NO. DOWNLOAD
2018-0101
2018-0101
Cat. No. Product name Field of application
DC40520 LEI-401 LEI-401 is a first-in-class, selective, and CNS-active NAPE-PLD (N-acylphosphatidylethanolamine phospholipase D) inhibitor, with an IC50 of 27 nM. LEI-401 modulates emotional behavior in mice.
DC7591 CAY10650 CAY10650 is a highly potent (IC50 = 12 nM) cPLA2α inhibitor.
DC7574 FIPI Potent phosholipase D (PLD) inhibitor (IC50 values are 20 and 25 nM for PLD2 and PLD1 respectively).
DC9874 ML-348(ML348) ML 348(ML348) is a selective and reversible lysophospholipase 1 (LYPLA1) inhibitor (IC50 = 210 nM).
DC7526 Varespladib LY315920 (Varespladib) is a potent and selective human non-pancreatic secretory phospholipase A2 (hnsPLA) inhibitor with IC50 of 7 nM,. Phase 3.
DC7397 Darapladib Darapladib is a selective and orally active inhibitor of Lp-PLA2 (IC50= 270 pM)
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