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Cefdinir

Cefdinir ??? ???
?? ??:
91832-40-5
???:
Cefdinir
???(??):
Omnicef;Cefzon;CFDN;Omnice;FK-482;CI 983;Novacef;CEFDINIR;cefdinyl;bmy28488
CBNumber:
CB7483101
???:
C14H13N5O5S2
??? ??:
395.41
MOL ??:
91832-40-5.mol

Cefdinir ??

???
>180°C dec.
??
1.89±0.1 g/cm3(Predicted)
?? ??
Keep in dark place,Sealed in dry,2-8°C
???
?? HCl: ?? ???
?? ?? (pKa)
9.70(at 25℃)
??? ??
??
??? ??
??? ??
??
?? ????? ?? ?????
???
?? ???
?? ??(λmax)
295nm(DMSO)(lit.)
Merck
14,1920
BCS Class
4
InChIKey
RTXOFQZKPXMALH-GHXIOONMSA-N
SMILES
N12[C@@]([H])([C@H](NC(/C(/C3=CSC(N)=N3)=N\O)=O)C1=O)SCC(C=C)=C2C(O)=O
CAS ??????
91832-40-5(CAS DataBase Reference)
??
  • ?? ? ?? ??
  • ?? ? ???? ?? (GHS)
WGK ?? 3
RTECS ?? XI0367250
HS ?? 2941906000
?? LD50 orl-rat: >5600 mg/kg IYKEDH 23,93,1992
????(GHS): GHS hazard pictograms
?? ?: Danger
??·?? ??:
?? ??·?? ?? ?? ?? ?? ?? ? ?? ?? P- ??
H317 ????? ?? ??? ??? ? ?? ?? ??? ?? ?? 1 ?? GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 ?? ? ????? ??, ?? ?? ?? ?? ?? ??? ? ?? ??? ??? ?? ?? 1 ?? GHS hazard pictograms P261, P285, P304+P341, P342+P311,P501
??????:
P261 ??·?·??·???·??·...·????? ??? ????.
P272 ??? ??? ??? ??? ???? ???.
P280 ????/???/???/?????? ?????.
P284 ?? ???? ?????.
P501 ...? ??? / ??? ?? ???.
NFPA 704
0
2 0

Cefdinir MSDS


8-[2-(2-amino-1,3-thiazol-4-yl)-1-hydroxy-2-nitroso-ethenyl]amino-4-ethenyl-7-oxo-2-thia-6-azabicyclo[4.2.0]oct-4-ene-5-carboxylicacid

Cefdinir C??? ??, ??, ??

??

Cefdinir is an orally active, beta-lactamase stable cephalosporin with a broad spectrum of activity. Compared to other oral cephalosporins, cefdinir is more potent against Gram-positive bacteria, especially Staphylococci. Its activity against Gram-negative bacteria such as E.coli,K. pneumoniae and P.mirabilis is similar to cefixime, but superior to cefaclor and cephalexin.

??? ??

Pale Yellow Solid

??

A Cephalosporin antibiotic structurally similar to Cefixime

??

ChEBI: A cephalosporin compound having 7beta-2-(2-amino-thiazol-4-yl)-2-[(Z)-hydroxyimino]-acetylamino- and 3-vinyl side groups.

Antimicrobial activity

An oral cephalosporin similar in structure to cefixime, but with a slightly modified side chain at the 7-amino position. Activity is similar to that of cefixime, but it is more active, especially against staphylococci. It is not hydrolyzed by staphylococcal or the common plasmid-mediated enterobacterial β-lactamases. An enhancing effect on phagocytosis has been demonstrated in vitro.
Oral absorption is about 35%. A 200 mg oral dose achieves a plasma concentration of 1 mg/L after c. 3 h. Absorption is reduced after a fatty meal. Concentrations equal to or higher than corresponding plasma levels were present in blister fluid 6–12 h after administration of an oral dose. The plasma halflife is 1.5 h. Protein binding is 60–70%. A total of 12–20% of the dose was excreted in the urine within 12 h, the renal elimination declining with increasing dose. The elimination half-life and peak plasma concentration are increased in renal failure. About 60% of the drug is removed by hemodialysis.
Side effects and uses are those common to oral cephalosporins.

Safety Profile

Moderately toxic by ingestion andintravenous routes. Low toxicity by intraperitoneal andsubcutaneous routes. Experimental reproductive effects.When heated to decomposition it emits toxic vapors ofNOx and SOx.

Cefdinir ?? ?? ? ???

???

Amine compound ???????? ??? ????????? ? (???????????)??????? ???? N-(Trimethylsilyl)acetamide N,N-????????? ???? ??? ??? S-2-BENZOTHIAZOLYL (Z)-2-(5-AMINO-1,2,4-THIADIAZOL-3-YL)-2-METHOXYIMINO THIOACETATE (Benzothiazol-2-yl)-(Z)-2-trityloxyimino-2-(2-aminothiazole-4-yl)-thioacetate 7-AVCA

?? ??

Cefdinir ?? ??

???( 492)?? ??
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Cefdinir ?? ??:

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