20ALPHA-HYDROXYCHOLESTEROL
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20ALPHA-HYDROXYCHOLESTEROL ??
- ???
- 136-137°C
- ?? ?
- 512.3±23.0 °C(Predicted)
- ??
- 1.03±0.1 g/cm3(Predicted)
- ?? ??
- Inert atmosphere,2-8°C
- ???
- DMSO ?? ???? ?????.
- ??? ??
- Solid
- ?? ?? (pKa)
- 15.04±0.70(Predicted)
- ??
- ???
- ???
- ??? ?? ?????? 1? ?? ??????. DMSO ?? ??? ??? -20°?? ?? 3?? ?? ??? ? ????.
??
| WGK ?? | 3 |
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20ALPHA-HYDROXYCHOLESTEROL C??? ??, ??, ??
??
20(S)-hydroxy Cholesterol is an allosteric agonist of the smoothened (Smo) receptor that activates the hedgehog (Hh) signaling pathway with an EC50 value of approxiately 3 μM in a gene transcription reporter assay using NIH3T3 cells. 20(S)-hydroxy Cholesterol is necessary for normal Hh signaling. It induces Smo accumulation in primary cilia, an early event in signaling, and binds to the extracellular, cysteine-rich domain of Smo. 20(S)-hydroxy Cholesterol also stimulates osteogenic differentiation of pluripotent bone marrow stromal cells, a process mediated via Hh and Notch signaling.??? ??
White Solid??
A metabolite of Cholesterol. Cholesterol oxidation product having cytotoxicity effects??
ChEBI: An oxysterol that is cholesterol substituted by a hydroxy group at position 20.20ALPHA-HYDROXYCHOLESTEROL ?? ?? ? ???
???
?? ??
20ALPHA-HYDROXYCHOLESTEROL ?? ??
???( 67)?? ??
| ??? | ?? | ??? | ?? | ?? ? | ?? |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569266 15319487004 |
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| Chemsky（shanghai）International Co.,Ltd. | 021-50135380 |
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20ALPHA-HYDROXYCHOLESTEROL ?? ??:
???? ??(??-4-)
2,3-DIMETHYL-2-HEXANOL
4-CYCLOHEXYLCYCLOHEXANOL
5-ETHYL-3-NONANOL
3-DECANOL
5-METHYL-5-NONANOL
2-BUTYL-1-OCTANOL
(S)-(+)-4-METHYL-2-PENTANOL
6-TRIDECANOL
dodec-11-enol
20ALPHA-HYDROXYCHOLESTEROL
4-METHYL-5-OCTANOL
3-DODECANOL
TRANS-9-DODECEN-1-OL
(S)-(+)-2-NONANOL
4-METHYL-4-PENTEN-2-OL
3-METHYL-4-OCTANOL