ChemicalBook >> CAS DataBase List >>R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
- CAS No.
- 125941-87-9
- Chemical Name:
- R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
- Synonyms
- R(+)-SCH-23390;SCH 23390(HCI);SCH 23390 hydrochlor;SCH 23390 HYDROCHLORIDE;SCH 23390 hydrochloride NEW;SCH-23390 hydrochloride, 10 mM in DMSO;(+)-SCH23390 Hydrochloride, 98.0+ % (HPLC);R(+)-SCH-23390 HYDROCHLORIDE SELECTIVE D 1 DOPAMINE;SCH23390 HYDROCHLORIDE; SCH-23390 HYDROCHLORIDE; R-(+)-SCH23390 HYDROCHLORIDE;R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
- CBNumber:
- CB62131148
- Molecular Formula:
- C17H18ClNOHCl
- Molecular Weight:
- 324.24
- MDL Number:
- MFCD00069249
- MOL File:
- 125941-87-9.mol
- MSDS File:
- SDS
Last updated:2025-01-27 09:38:02
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Properties
| alpha | +27～+31°(D/20℃)(c=0.5,DMF) |
|---|---|
| storage temp. | protect from light |
| solubility | H2O: >5mg/mL |
| form | solid |
| color | white |
| optical activity | [α]/D +32.1°, c = 1 in DMF(lit.) |
| Water Solubility | water: 100mM |
| FDA UNII | 4S8T3E2F4Z |
| EPA Substance Registry System | (5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride (125941-87-9) |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride price More Price(35)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | D054 | R(+)-SCH-23390 hydrochloride ≥98% (HPLC), solid | 125941-87-9 | 5mg | $115 | 2024-03-01 | Buy |
| Sigma-Aldrich | D054 | R(+)-SCH-23390 hydrochloride ≥98% (HPLC), solid | 125941-87-9 | 10mg | $178 | 2024-03-01 | Buy |
| Sigma-Aldrich | 5.05723 | SCH 23390 Hydrochloride - CAS 125941-87-9 - Calbiochem | 125941-87-9 | 10MG | $172 | 2023-06-20 | Buy |
| Cayman Chemical | 15631 | SCH 23390 (hydrochloride) ≥99% | 125941-87-9 | 10mg | $141 | 2024-03-01 | Buy |
| Cayman Chemical | 15631 | SCH 23390 (hydrochloride) ≥99% | 125941-87-9 | 50mg | $524 | 2024-03-01 | Buy |
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Chemical Properties,Uses,Production
Uses
R(+)-SCH-23390 hydrochloride has been used:
- for intraperitoneal injection into experimental rats to study the role of D1 receptor in sensitization
- as a D1 receptor-selective antagonist for intracranial drug infusions
- as an antagonist of D1 receptor to study its effect on learning ability in fish
Uses
A selective dopamine D1 receptor antagonist.
Biological Activity
Potent D 1 antagonist (K i values are ~ 0.2, 0.3, ~ 1100, ~ 800 and ~ 3000 nM at D 1 , D 5 , D 2 , D 3 and D 4 receptors respectively). Also an agonist at 5-HT 1C/2C receptors (K i = 6.3 nM) in vitro .
Biochem/physiol Actions
R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.
storage
+4°C (desiccate)
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 88)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29810 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49734 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2922 | 55 | |
| J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
View Lastest Price from R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-17 | SCH-23390 hydrochloride
125941-87-9
|
US $33.00-71.00 / mg | 99.51% | 10g | TargetMol Chemicals Inc. | ||
 |
2020-01-14 | R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
125941-87-9
|
US $9.80 / KG | 1g | ≥99% | 100kg | Career Henan Chemical Co |
-
- SCH-23390 hydrochloride
125941-87-9
- US $33.00-71.00 / mg
- 99.51%
- TargetMol Chemicals Inc.
-
- R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
125941-87-9
- US $9.80 / KG
- ≥99%
- Career Henan Chemical Co
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Spectrum
125941-87-9(R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride)Related Search:
SCH772984
6-(p-Nitrophenyl)pyrrolo[2,1-d][1,5]benzothiazepine 5,5-dioxide
SCH 58261
2-CHLORO-5-METHYLPHENOL
P-CHLORO-BETA-METHYL-PHENETHYLAMINE HYDROCHLORIDE
2-(3-Chlorophenyl)ethylamine
4-Chlorophenethylamine
2-CHLORO-4,5-DIMETHYLPHENOL
[2-(3-CHLORO-PHENYL)-ETHYL]-METHYL-AMINE
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
1of4
R(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE
SCH 23390 HYDROCHLORIDE
R(+)-SCH-23390 HYDROCHLORIDE SELECTIVE D 1 DOPAMINE
(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride
SCH 23390(HCI)
(+)-SCH23390 Hydrochloride, 98.0+ % (HPLC)
R(+)-SCH-23390
R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
SCH23390 HYDROCHLORIDE; SCH-23390 HYDROCHLORIDE; R-(+)-SCH23390 HYDROCHLORIDE
SCH 23390 hydrochloride NEW
SCH 23390 hydrochlor
(R)-8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol hydrochloride
SCH-23390 hydrochloride, 10 mM in DMSO
125941-87-9
Dopamine receptor
Aromatics
Chiral Reagents
Heterocycles
Intermediates & Fine Chemicals
Pharmaceuticals