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R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Struktur
125941-87-9
CAS-Nr.
125941-87-9
Englisch Name:
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride
Synonyma:
R(+)-SCH-23390;SCH 23390(HCI);SCH 23390 hydrochlor;SCH 23390 HYDROCHLORIDE;SCH 23390 hydrochloride NEW;(+)-SCH23390 Hydrochloride, 98.0+ % (HPLC);R(+)-SCH-23390 HYDROCHLORIDE SELECTIVE D 1 DOPAMINE;SCH23390 HYDROCHLORIDE; SCH-23390 HYDROCHLORIDE; R-(+)-SCH23390 HYDROCHLORIDE;R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine;(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride
CBNumber:
CB62131148
Summenformel:
C17H18ClNOHCl
Molgewicht:
324.24
MOL-Datei:
125941-87-9.mol

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Eigenschaften

alpha 
+27～+31°(D/20℃)(c=0.5,DMF)
storage temp. 
protect from light
L?slichkeit
H2O: >5mg/mL
Aggregatzustand
solid
Farbe
white
Optische Aktivit?t
[α]/D +32.1°, c = 1 in DMF(lit.)
EPA chemische Informationen
(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride (125941-87-9)

Sicherheit

WGK Germany  3

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

A selective dopamine D1 receptor antagonist.

Biologische Aktivit?t

Potent D 1 antagonist (K i values are ~ 0.2, 0.3, ~ 1100, ~ 800 and ~ 3000 nM at D 1 , D 5 , D 2 , D 3 and D 4 receptors respectively). Also an agonist at 5-HT 1C/2C receptors (K i = 6.3 nM) in vitro .

Biochem/physiol Actions

R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity.

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 83)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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 marketing@targetmol.com United States 32161 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Shanghai Acmec Biochemical Technology Co., Ltd. 		+undefined18621343501
 product@acmec-e.com China 33338 58
SHANGHAI KEAN TECHNOLOGY CO., LTD. 		+8613817748580
 cooperation@kean-chem.com China 40066 58
Shanghai Boyle Chemical Co., Ltd.
sales@boylechem.com China 2922 55
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
 jkinfo@jkchemical.com China 96815 76

125941-87-9()Verwandte Suche:

  • R(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE
  • SCH 23390 HYDROCHLORIDE
  • R(+)-SCH-23390 HYDROCHLORIDE SELECTIVE D 1 DOPAMINE
  • (5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride
  • SCH 23390(HCI)
  • (+)-SCH23390 Hydrochloride, 98.0+ % (HPLC)
  • R(+)-SCH-23390
  • R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
  • SCH23390 HYDROCHLORIDE; SCH-23390 HYDROCHLORIDE; R-(+)-SCH23390 HYDROCHLORIDE
  • SCH 23390 hydrochloride NEW
  • SCH 23390 hydrochlor
  • (R)-8-Chloro-3-methyl-5-phenyl-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-ol hydrochloride
  • 125941-87-9
  • Dopamine receptor
  • Aromatics
  • Chiral Reagents
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
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