| Identification | Back Directory | [Name]
R-(-)-7-Chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine, hydrochloride | [CAS]
125941-87-9 | [Synonyms]
SCH 23390(HCI)
R(+)-SCH-23390
SCH 23390 HYDROCHLORIDE
SCH 23390 hydrochloride NEW
(+)-SCH23390 Hydrochloride, 98.0+ % (HPLC)
R(+)-SCH-23390 HYDROCHLORIDE SELECTIVE D 1 DOPAMINE
R(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine
SCH23390 HYDROCHLORIDE; SCH-23390 HYDROCHLORIDE; R-(+)-SCH23390 HYDROCHLORIDE
(5R)-8-Chloro-2,3,4,5-tetrahydro-3-methyl-5-phenyl-1H-3-benzazepin-7-ol hydrochloride
R(+)-7-CHLORO-8-HYDROXY-3-METHYL-1-PHENYL-2,3,4,5-TETRAHYDRO-1H-3-BENZAZEPINE HYDROCHLORIDE | [Molecular Formula]
C17H18ClNOHCl | [MDL Number]
MFCD00069249 | [MOL File]
125941-87-9.mol | [Molecular Weight]
324.24 |
| Hazard Information | Back Directory | [Uses]
A selective dopamine D1 receptor antagonist. | [Biological Activity]
Potent D 1 antagonist (K i values are ~ 0.2, 0.3, ~ 1100, ~ 800 and ~ 3000 nM at D 1 , D 5 , D 2 , D 3 and D 4 receptors respectively). Also an agonist at 5-HT 1C/2C receptors (K i = 6.3 nM) in vitro . | [Biochem/physiol Actions]
R(+)-SCH-23390 hydrochloride is a selective D1 dopamine receptor antagonist. It has greater binding capacity towards 5-hydroxytryptamine 2 (5-HT2) and 5-HT1C serotonin receptor subtypes in in vitro. R(+)-SCH-23390 has a half-life of about 25 minutes after administration. It is known to possess anti-stereotypic effect and cataleptogenic effect. It also has inhibitory effect on motor activity. | [storage]
+4°C (desiccate) |
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