Rosuvastatin calcium
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- CAS-Nr.
- 147098-20-2
- Englisch Name:
- Rosuvastatin calcium
- Synonyma:
- CRESTOR;ROSUVASTATIN CA;Rosuvastatin Calcium CRS;Rosuvastatin for system suitability CRS;BD-04;ZD4522;Rostar;S 4522;Fortius;Rosuvastadine
- CBNumber:
- CB9482678
- Summenformel:
- C22H30CaFN3O6S
- Molgewicht:
- 523.63
- MOL-Datei:
- 147098-20-2.mol
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Rosuvastatin calcium Eigenschaften
- Schmelzpunkt:
- 122°C
- alpha
- D24 +14.8° (c = 1.012 in 50% methanol)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO : 25 mg/mL (49.94 mM; Need ultrasonic)H2O : 1 mg/mL (2.00 mM; Need ultrasonic)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Optische Aktivit?t
- [α]/D +12 to +18°, c = 1 in methanol: water (1:1)
- maximale Wellenl?nge (λmax)
- 243nm(Phosphate buffer sol.)(lit.)
- Merck
- 14,8270
- InChIKey
- JSVIQRTVYKCCOM-LMRKSJJTNA-N
- SMILES
- C(/C1=C(N=C(N(C)S(=O)(=O)C)N=C1C1C=CC(F)=CC=1)C(C)C)=C\[C@@H](O)C[C@@H](O)CC(=O)O.[Ca] |&1:24,27,r|
- CAS Datenbank
- 147098-20-2(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| RTECS-Nr. |
MJ9675070 |
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| HS Code |
29350090 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
| H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
| H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
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| Sicherheit |
| P261 |
Einatmen von Staub vermeiden. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Rosuvastatin calcium Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White to Off-White Crystalline Solid
Verwenden
Rosuvastatin Calcium Salt is a selective, competitive HMG-CoA reductase inhibitor. Antilipemic.
Definition
ChEBI: An organic calcium salt that is the hemicalcium salt of rosuvastatin.
Allgemeine Beschreibung
Rosuvastatin calcium (ROS) has a molecular mass of 1001.14. ROS is a member of the "statins" group and is a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor.
Mechanism of action
Rosuvastatin is a statin medication and a competitive inhibitor of the enzyme HMG-CoA (3-hydroxy-3-methylglutaryl coenzyme A) reductase, which catalyzes the conversion of HMG-CoA to mevalonate, an early rate-limiting step in cholesterol biosynthesis.24 Rosuvastatin acts primarily in the liver, where decreased hepatic cholesterol concentrations stimulate the upregulation of hepatic low density lipoprotein (LDL) receptors which increases hepatic uptake of LDL. Rosuvastatin also inhibits hepatic synthesis of very low density lipoprotein (VLDL).44 The overall effect is a decrease in plasma LDL and VLDL.
Rosuvastatin calcium Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Rosuvastatin calcium Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 858)Lieferanten
147098-20-2()Verwandte Suche:
- (+)-bis[7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3R,5S-dihydroxy-6(E)-heptenoic acid]calcium salt
- calcium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethan-3-ylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate
- ZD4522
- (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[N-methyl(n-methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-Hep
- Rosuvastatin (as Ca salt)
- ROSUVASTATIN, CALCIUM SALT
- ROSUVASTATIN CALCIUM
- Calcium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-y
- (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[N-methyl(n-methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-6-Heptenoic calcium
- RosuvastatinCalcium&Z7,Z8,R3
- 7-{4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid
- Rosuvastatin CalciuM
(3R,5S,6E)-7-[4-(4-fluorophenyl)-6-(1-Methylethyl)-2-[N-Methyl(n-Methylsulfonyl)aMino]-5-pyriMidinyl]-3,5-dihydroxy-6-Heptenoic calciuM
- Rosuvastatin Calium
- Fortius
- Rostar
- Rosuvastatin hemicalcium
- S 4522
- ZD 4522, Calcium Salt
- Rosuvastain Calcium
- rosuvastatin
Rosuvastatin CalciuM
- (3R,5R,6E)-7-[4-(4-fluorophenyl)-2-(N-MethylMethanesulfonaMido)-6-(propan-2-yl)pyriMidin-5-yl]-3,5-dihydroxyhept-6-enoic acid
- (+)-(3R,5S)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-Methyl-N-MethanesulfonylaMino)pyriMidin-5-yl]-3,5-dihydroxy-6(E)-heptenoic acid calciuM salt (2:1)
- Rosuvastatin calciuM(Crestor)
- Rosuvastatin CalciuM (AMorphous)
- Rosuvastatin CalciuM (ForM A)
- BD-04
- (3R,5S,6E)-7-{4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid calcium salt
- Rosuvastatin calcium Solution, 100ppm
- RosuvastatinCalcium>
- Rosuvastatin Impurity 116
- Rosuvastatin CaL
- Rosuvastatin for system suitability
- Calcium (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoate
- Rosuvastatin calcium USP/EP/BP
- Rosuvastatin Calcium，Rusuvastatin Calcium
- (3R,5S,6E)-7-{4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5-dihydroxyhept-6-enoic acid
- Rosuvastatin S-Isomer
- Rosuvastatin-d3 Calcium Salt
- Rosuvastatin Calcium (Y0001719)
- Rosuvastatin calciumQ: What is
Rosuvastatin calcium Q: What is the CAS Number of
Rosuvastatin calcium Q: What is the storage condition of
Rosuvastatin calcium Q: What are the applications of
Rosuvastatin calcium
- Rosuvastatin for system suitability (Y0001721)
- Rosuvastatin Calcium (1606015)
- (+/-)-Fargesin
- 6-Heptenoic acid, 7-[4-(4-fluorophenyl)-6-(1-methylethyl)-2-[methyl(methylsulfonyl)amino]-5-pyrimidinyl]-3,5-dihydroxy-, calcium salt (2:1), (3R,5S,6E)-
- (3R,5S,6E)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-[methyl(methylsulfonyl)amino]pyrimidin-5-yl])-3,5-dihydroxyhept-6-enoic acid hemicalcium salt
- Rosuvastatin Calcium(W.S)
- ZD 4522 Calcium
- ROSUVASTATIN CALCIUM (ROSUVASTATIN HEMICALCIUM)
- Rosuvastadine
- ROSUVASTATIN CA
- CRESTOR
- Rosuvastatin for system suitability CRS
- Rosuvastatin Calcium CRS
- (E)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate
- Rosuvastatin Calcium Salt CRS
- Rosuvastatin Calcium
(3R,5S,6E)-7-{4-(4-Fluorophenyl)-6-isopropyl-2- [methyl(methylsulfonyl)amino]pyrimidin-5-yl}-3,5- dihydroxyhept-6-enoic acid calcium salt
- Rosuvastatin Calcium (BP)
- (3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid, calcium salt
