Pitavastatin calcium Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Pitavastatin, launched for the treatment of hypercholesterolemia, belongs to the family of second-generation statins, also referred to as superstatins due to their improved efficacy as cholesterol lowering agents. Like other statins, pitavastatin reduces plasma cholesterol levels by competitively inhibiting HMG-CoA reductase, the rate-limiting enzyme of cholesterol biosynthesis in the liver. It is a more potent inhibitor of HMG-CoA reductase than the previously marketed statins and has the potential benefit of not undergoing significant metabolism by CYP3A4. Pitavastatin is synthesized in a multi-step sequence, including the key step of introducing the dihydroxyheptenoate side chain by cross-coupling of a 3-iodoquinoline intermediate with an alkenylborane reagent. Unlike rosuvastatin, pitavastatin has a high oral bioavailability (～80%). Plasma protein binding is also high for pitavastatin (＞95%), and regardless of the dosing, the highest tissue levels are found in the liver, its target organ. After oral administration, the peak plasma concentration is reached at ,0.8 h and the mean elimination half-life is ～11 h. Pitavastatin is only minimally metabolized, mainly by CYP2C8 and CYP2C9, and the predominant route of elimination of the parent drug and its metabolites is by means of bile excretion followed by elimination in the feces. In clinical studies, oral doses of 2–4 mg/day of pitavastatin produced dose-dependent reduction in LDL-cholesterol levels by 40–48% from baseline in patients with heterozygous familial hypercholesterolemia. In a 12-week double-blind comparative study, pitavastatin (2 mg/day) was more effective than pravastatin (10 mg/day) in reducing LDL-cholesterol levels (38 and 18%, respectively); however, both agents produced similar increases in HDL-cholesterol (～9%). The drug was well tolerated and the adverse reactions were mild and transient.

Chemische Eigenschaften

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Verwenden

Pitavastatin calcium (Livalo) is a novel member of the medication class of statins

Definition

ChEBI: The calcium salt of pitavastatin. Used for treatment of hypercholesterolemia (elevated levels of cholesterol in the blood) on patients unable to sufficiently lower their cholesterol levels by diet and exercise.

Hazard

A poison by ingestion.

Sicherheitsprofil

A poison by ingestion.Experimental reproductive effects. When heated todecomposition it emits toxic vapors of NOx and Fí.

Pitavastatin calcium Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Pitavastatin calcium Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Beijing Hope Pharmaceutical Co., Ltd.	+86-010-67886402 +8613611125266	market@hopelife.cn	China	72	58
Hebei Weibang Biotechnology Co., Ltd	+8615531157085	abby@weibangbio.com	China	8810	58
Hebei Mojin Biotechnology Co., Ltd	+86 13288715578 +8613288715578	sales@hbmojin.com	China	12835	58
Hebei Chuanghai Biotechnology Co,.LTD	+86-13131129325	sales1@chuanghaibio.com	China	5889	58
Changzhou Rokechem Technology Co., Ltd.	18758118018	sales001@rokechem.com	China	255	58
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1001	58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD.	+86-18600796368 +86-18600796368	sales@sjar-tech.com	China	456	58
Beijing Cooperate Pharmaceutical Co.,Ltd	010-60279497	sales01@cooperate-pharm.com	CHINA	1803	55
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21634	55
Shanghai Yingrui Biopharma Co., Ltd.	+86-21-33585366 - 03@	sales03@shyrchem.com	CHINA	738	60

147526-32-7()Verwandte Suche:

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• Pitavasttin Calcium
• Pitavastatin Calcium /NK-104
• (+)-Monocalciunbis{(3r,5s,6e)-7-[2-cyclopropyl-4-(4-fluorophenyl-3-quinolyl]-3,5-dihydroxy-6-heptenotate}
• Pitavastatin calciuM(Livalo)
• Calcium (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl)-3,5-dihydroxyhept-6-enoate
• (3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid,calcium salt (2:1)
• NK-104 Calcium
• Pitavastatin CalciuM DISCONTINUED
• Pitavastatin (calcium salt)
• monocalciumbis[(3R,5S,6E)-7-(2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolyl)-3,5-Dihydroxy-6-heptenoate](+)a- Phenethylamine Sal
• Pitavastatin Calcuim
• Pitavastatin calcium, >=98.5%
• Pitavastatin Calciu
• Calcium (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)-quinolin-3-yl)-3,5-dihydroxyhept-6-enoat
• PITAVASTATIN CALCIUM 3S-5R ISOMER IMP
• 6-heptenoicacid,7-(2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl)-3,5-dihydro
• calciumsalt(2:1),(3r,5s,6e)-xy
• nk104
• nk104(acid)
• ITAVASTATIN CA
• ITAVASTATIN CALCIUM
• PITAVASTATIN CALCIUM
• ：(+)-monocalciumbis{(3r,5s,6e)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoate}
• monocalciumbis[(3R,5S,6E)-7-(2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolyl)-3,5-Dihydroxy-6-heptenoate](+)α－ Phenethylamine Salt
• D01862
• PITAVASTATINCALCIUM(FORR&DONLY)
• (+)-Monocalciumbis{(3R,5S,6E)-7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolyl]-3,5-dihydroxy-6-heptenoate}
• PITAVASTATINHEMICALCIUM
• monocalciumbis[(3R,5S,6E)-7-(2-Cyclopropyl-4-(4-Fluorophenyl)-3-Quinolyl)-3,5-Dihydroxy-6-heptenoate](+)a- Phenethylamine Salt
• 147526-32-7 Pitavastatin Calcium
• (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic Acid Calcium Salt
• (3R,5S,6E)-7-[2-Cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-6-heptenoic acid hemicalcium salt
• Pitavastatin calcium API
• Pitavastatin hemicalcium salt
• nisvastatin
• P-872441
• Pitavastatin caL
• DataBase Referen
• 6-Heptenoic acid, 7-[2-cyclopropyl-4-(4-fluorophenyl)-3-quinolinyl]-3,5-dihydroxy-, calcium salt (2:1), (3R,5S,6E)-
• Pitavastatin calcium USP/EP/BP
• PITAVASTATIN CALCIUM CAS NO 147526-32-7
• Pitavastatin CalciumQ: What is Pitavastatin Calcium Q: What is the CAS Number of Pitavastatin Calcium Q: What is the storage condition of Pitavastatin Calcium Q: What are the applications of Pitavastatin Calcium
• Pitavastatin D4 Calcium SaltQ: What is Pitavastatin D4 Calcium Salt Q: What is the CAS Number of Pitavastatin D4 Calcium Salt Q: What is the storage condition of Pitavastatin D4 Calcium Salt Q: What are the applications of Pitavastatin D4 Calcium Salt
• Pitavastatin calcium high purity
• Pivastatin calcium
• Pitavastatin Impurity 11 CaH2
• 147526-32-7
• C50H46CaF2N2O8
• C50H46F2N2O8Ca2
• C25H23FNO42Ca
• C50H46F2N2O8Ca
• C50H48CaF2N2O8
• Livalo
• API
• chemical
• Pharmaceuticals
• Cardiovascular Series
• Active Pharmaceutical Ingredients