Atracuriumbesilat
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- CAS-Nr.
- 64228-81-5
- Bezeichnung:
- Atracuriumbesilat
- Englisch Name:
- Atracurium besylate
- Synonyma:
- ATRACURIUM BESILATE;Atracurim besylate;51W89;BW-33A;Tracur;TRACRIUM;51W-89：Nimbex;Wellcome 33A74;Atracurium BesyL;ATRACURIUM BESYLAT
- CBNumber:
- CB9379882
- Summenformel:
- C65H82N2O18S2
- Molgewicht:
- 1243.48
- MOL-Datei:
- 64228-81-5.mol
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Atracuriumbesilat Eigenschaften
- Schmelzpunkt:
- 85-90°C
- storage temp.
- Inert atmosphere,2-8°C
- L?slichkeit
- H2O: ~27 mg/mL
- Aggregatzustand
- powder
- Farbe
- white
- InChIKey
- YXSLJKQTIDHPOT-UHFFFAOYSA-N
- CAS Datenbank
- 64228-81-5(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| S-S?tze: |
24/25 |
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| WGK Germany |
3 |
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| HS Code |
29334900 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Atracuriumbesilat Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
White to yellowish-white powder, slightly hygroscopic
Verwenden
A neuromuscular blocking agent
Definition
ChEBI: The bisbenzenesulfonate salt of atracurium.
Biologische Funktion
Atracurium besylate (Tracrium) is a benzylisoquinolinium
compound like d-tubocurarine. Its actions are similar
to those of d-tubocurarine, but its duration of action
is shorter (45 minutes) because of spontaneous degradation
of the molecule (Hofmann elimination). Because
of this, atracurium is useful in patients with low or atypical
plasma cholinesterase and in patients with renal or
hepatic impairment.
Allgemeine Beschreibung
Atracurium besylate, 2-(2-carboxyethyl)-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-veratrylisoquinolinium benzenesulfonate pentamethyleneester (Tracrium), is a nondepolarizing neuromuscular blockingagent that is approximately 2.5 times more potent thand-tubocurarine. Its duration of action (half-life, 0.33 hours)is much shorter than that of d-tubocurarine.
Clinical Use
Atracurium Besylate is metabolized rapidly and nonenzymatically to yield laudanosineand a smaller quaternary compound ,which do not have neuromuscular blocking activity. In vitroexperiments show that atracurium besylate breaks down atpH 7.4 and 37°C by a Hoffman elimination reaction.Atracurium besylate undergoes enzymatic decompositionof its ester function to yield an inactive quaternary alcoholand quaternary acid. AChE inhibitors such as neostigmine,edrophonium, and pyridostigmine antagonize paralysis byatracurium besylate.
Atracuriumbesilat Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Triethylammoniumchlorid
Methylbenzolsulfonat
Salmeterol xinafoate
Anhydrous benzene
Papaverin
Acryloylchlorid
1,2,3-Trihydroxybenzol
Pentan-1,5-diol
Benzyl(purin-6-yl)amin
spectrum
1-[(3,4-Dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxyisochinolin
(1R,2R,3aS,9aS)-2,3,3a,4,9,9a-Hexahydro-1-[(3S)-3-hydroxyoctyl]-1H-benz[f]indene-2,5-diol
N,N'-Pentan-1,5-diyldiammoniumdichlorid
Downstream Produkte
Atracuriumbesilat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 469)Lieferanten
64228-81-5(Atracuriumbesilat)Verwandte Suche:
- BW-33A
- 2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinolinium dibenzenesulfonate
- 2，2’-[1，5-Pentanediylbis[oxy(3-oxcr3，1-propanediyl)]]bis[1-[(3，4-dimethoxyphenyl)methyl]-1，2，3，4-tetrahydro-6，7-dimethoxy-2-methylisoquinolinium]dibenzenesulfonate
- 51W-89：Nimbex
- Atraeurium Besylate
- Cisatracudum Besylate
- BW-33A, Tracrium, 2,2μ-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]dibenzenesulfonate
- Isoquinolinium, 2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-, dibenzenesulfonate
- Pentamethylen bis(3-(1,2,3,4-tetrahydro-6,7-dimethoxy-1-(3,4-dimethoxybenzyl)-2-methyl-2-isochinolyl)propionat)bis(benzolsulfonat)
- Atracurium besylate,2,2′-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methylisoquinolinium]dibenzenesulfonate, BW-33A, Tracrium
- Atracurium Besylate (100 mg)
- 2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)meth
- 2,2'-[1,5-pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-Isoquinolinium, benzenesulfonate (1:2)
- AtracuriuM Besilete
- (1R,2R)-1-[(3,4-diMethoxyphenyl)Methyl]-2-(3-{[5-({3-[(1R,2R)-1-[(3,4-diMethoxyphenyl)Methyl]-6,7-diMethoxy-2-Methyl-1,2,3,4-tetrahydroisoquinolin-2-iuM-2-yl]propanoyl}oxy)pentyl]oxy}-3-oxopropyl)-6,7-diMethoxy-2-Methyl-1,2,3,4-tetrahydroisoquinolin-2-iuM
- AtracuriuM besylate (TracriuM)
- 51W89
- Atracurium besylate, >=98%
- Atracurium Besylate (mixture of isomers)
- 2,2'-[1,5-PENTANEDIYLBIS[OXY(3-OXO-3,1-PROPANEDIYL)]]BIS[1-[3,4-DIMETHOXYPHENYL)METHYL]-1,2,3,4-TETRAHYDRO-6,7-DIMETHOXY-2-METHYLISOQUINOLINIUM]DIBENZENESULFONATE
- TRACRIUM
- ATRACURIUM BESILATE INJECTION
- AtracuriumBesylate(DMF)
- CisatracuriumBesilete
- Atracurim besylate Bp
- 2,2'-[1,5-Pentanediylbis[oxy(3-oxo-3,1-propanediyl)]]bis[1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-isoquinolinium Benzenesulfonate
- Atracurium Dibesylate
- Tracur
- Wellcome 33A74
- ATRACURIUM BESYLAT
- Atracuricum Besilate
- ATRACURIUM BESYLATE EP/BP
- AttracuriumBesylate
- CIS-ATRACURIUM BESYLETE
- ATRICURIUM BESYLATE
- ATRACURIUMBESYLATEUSP
- tracurium Besylate
- 3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydro-1H-isoquinolin-2-ium-2-yl]propanoic acid 5-[3-[1-[(3,4-dimethoxyphenyl)methyl]-6,7-dimethoxy-2-methyl-3,4-dihydr
- Atracurium besylate, 98%, a neuromuscular blocking agent
- Atracurium Besylate (mixture of isomers)>
- Atracurium for impurity F identification CRS
- Atracurium besilate CRS
- Atracurium Besylate,99%
- Atracurium besylate, a neuromuscular blocking agent
- Atracurium BesyL
- Mixture of the cis-cis, cis-trans and trans-trans isomers of 2,2\\\\\\\'-[Pentane-1,5-diylbis[oxy(3-oxopropane-1,3-diyl)]]bis[1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolinium] dibenzenesulfonate
- 2,2'-((Pentane-1,5-diylbis(oxy))bis(3-oxopropane-3,1-diyl))bis(1-(3,4-dimethoxybenzyl)-6,7-dimethoxy-2-methyl-1,2,3,4-tetrahydroisoquinolin-2-ium) benzenesulfonate
- Atracurium Besylate (BW-33A)
- Atracurium besilate (Y0000424)
- Atracurium besylateQ: What is
Atracurium besylate Q: What is the CAS Number of
Atracurium besylate Q: What is the storage condition of
Atracurium besylate Q: What are the applications of
Atracurium besylate
- Atracurium Besylate (1044800)
- ATRACURIUM BESILATE
- Atracurim besylate
- Bensulfuramtorisone
- Atracurium benzenesulfonate
- Atraculum besylate
- inflammatory,anticancer,Inhibitor,Atracurium besylate,neuromuscular blockade,inhibit,nAChR,GSC cells,Nicotinic acetylcholine receptors,bronchoconstriction
- Atracurium besilate API
