Amlodipine Besylate
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- CAS-Nr.
- 111470-99-6
- Englisch Name:
- Amlodipine Besylate
- Synonyma:
- AMLODIPINE BESILATE;NORVASC;Amlor;Calchek;AMlodipine bes;Amlodipine besilate (crystalline);Vazkor;Amcard;Lowrac;Norvas
- CBNumber:
- CB4127875
- Summenformel:
- C26H31ClN2O8S
- Molgewicht:
- 567.05094
- MOL-Datei:
- 111470-99-6.mol
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Amlodipine Besylate Eigenschaften
- Schmelzpunkt:
- 199-201°C
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: 20 mg/mL
- Aggregatzustand
- solid
- pka
- 8.6
- Farbe
- white
- Wasserl?slichkeit
- Soluble in DMSO (20 mg/mL), water (10 mM), chloroform, ethanol (14 mg/mL), and methanol.
- Merck
- 14,491
- BCS Class
- 1 (CLogP)
3 (LogP)
- InChIKey
- ZPBWCRDSRKPIDG-UHFFFAOYSA-N
- CAS Datenbank
- 111470-99-6(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P264 |
Nach Gebrauch gründlich waschen. |
| P264 |
Nach Gebrauch gründlich waschen. |
| P270 |
Bei Gebrauch nicht essen, trinken oder rauchen. |
| P301+P312 |
BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P501 |
Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen. |
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Amlodipine Besylate Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Anilodipine besylate is a new, once-daily, dihydropyridine calcium antagonist useful in
the treatment of hypertension and angina.
Chemische Eigenschaften
White Crystalline Solid
Verwenden
Amlodipine besylate is a L-type calcium channel blocker which may be used for the treatment of angina pectoris and hypertension. Amlodipine also inhibits growth of human epidermoid carcinoma A431 cells and has antireproductive effects in male rats.
Definition
ChEBI: The benzenesulfonate salt of amlodipine.
Allgemeine Beschreibung
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards. Amlodipine besylate is a calcium channel blocker, which inhibits the trans membrane influx of calcium ions into vascular smooth muscles and cardiac muscle. It belongs to the dihydropyridine family. It is used in combination with atorvastatin calcium to treat vasospastic angina, chronic stable angina, hypertension, in elevated serum triglyceride levels, primary dysbetalipoproteinemia.
Biologische Aktivit?t
L-type calcium channel blocker that displays antihypertensive properties. Inhibits Ca 2+ -induced contractions in depolarized rat aorta (IC 50 = 1.9 nM) and displays vasoprotective effects in cardiovascular disease. Inhibits proliferation of human vascular smooth muscle cells and epidermoid carcinoma A431 cells (IC 50 = 25 μ M).
Amlodipine Besylate Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Amlodipine Besylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 911)Lieferanten
111470-99-6()Verwandte Suche:
- Vazkor
- 3-Ethyl 5-Methyl 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate Benzenesulfonate
2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 3-Ethyl 5-Methyl Ester Benzenesulfona
- 3-ethyl 5-Methyl 2-((2-aMinoethoxy)Methyl)-4-(2-chlorophenyl)-6-Methyl-1,4-dihydropyridine-3,5-dicarboxylate benzenesulfonate
- 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid-3-ethyl 5-methyl ester, benzenesulfonate (1:1)
- Amlodipine besylate
Amlodipine besilate
- 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 3-Ethyl 5-Methyl Ester Benzenesulfonate
- 3-Ethyl 5-Methyl 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydro
- 2-[(2-AMINOETHOXY)-METHYL]-4-(2-CHLOROPHENYL)-1,4-DIHYDRO-6-METHYL-3,5-PYRIDINEDICARBOXYLIC ACID 3-ETHYL 5-METHYL ESTER BENZENE SULFONATE
- 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-3-ethoxycarbonyl-5-methoxycarbonyl-6-methyl-1,4-dihydropyridine benzenesulfonate
- Amlodipine Besylate (350 mg)
- Ethyl 2-[(2-aminoethoxy)methyl]-4-(2-chloropohenyl)-1,4-dihydro-5-(methoxycarbonyl)-6-methylpyridine-3-carboxylate benzenesulphonate
- 2-(2-Aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid 3-ethyl=5-methyl·benzenesulfonic acid
- C20H25ClN2O5C6H5SO3H
- AMLODIPINE BENZENESULFONATE
- AMLODIPINE BESYLATE
- 3,5-pyridinedicarboxylicacid,2-((2-aminoethoxy)methyl)-4-(2-chlorophenyl)-1,
- 4-dihydro-6-methyl-,3-ethyl-5-methylester,monobenzenesulfonate
- AMLODIPINE BESILATE MM(CRM STANDARD)
- AMLODIPINE BESYLATE EPY(CRM STANDARD)
- AMLODIPINEBESYLATE(SUBJECTTOPATENTFREE)
- (+-)-3-Ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate monobenzenesulfonate
- 3,5-Pyridinedicarboxylic acid, 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-, 3-ethyl 5-methyl ester, monobenzenesulfonate
- Amcard
- Amdepin
- Amdipin
- Amlodin
- Amlopin
- Amlosyn
- Antacal
- Benzenesulfonic acid, compd. with 3-ethyl 5-methyl 2-[(2-aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylate (1:1)
- Lowrac
- Monopina
- Norvas
- Norvask
- Tensivask
- UK 48340-26
- 2-[(2-Aminoethoxy)methyl]-4-(2-chlorophenyl)-1,4-dihydro-6-methyl-3,5-pyridinedicarboxylic acid 3-ethyl 5-methyl ester benzenesulfonate
- raw material amlodipine besylate
- Amlodipine Beaylate
- Amlodipine benzene sulfonic acid amlodipine
- Amlodipine besilate 111470-99-6
- 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic acid O3-ethyl ester O5-methyl ester
- Amlodipine Besilate RS
- Amlodipine Besylate >
- Amlodipine besilate CRS
- Amlodipine for peak identification CRS
- Amlodipine Besylte
- Amlodipine besilate Solution,100μg/mL
- 2-(2-Aminoethoxy)methyl-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylic Acid 3-Ethyl 5-Methyl Ester Benzenesulfona
- Amlodipine Besylate USP/EP/BP
- AmlodipineBesilatehcl88150-42-9 USP/EP/BP
- Amlodipine BesylateQ: What is
Amlodipine Besylate Q: What is the CAS Number of
Amlodipine Besylate Q: What is the storage condition of
Amlodipine Besylate Q: What are the applications of
Amlodipine Besylate
- Amlodipine besilate (Y0000049)
- Amlodipine For Peak IdentificationQ: What is
Amlodipine For Peak Identification Q: What is the CAS Number of
Amlodipine For Peak Identification
- Amlodipine for peak identification (Y0001067)
- Amlodipine Besylate (1029501)
- AMLODIPINE BESILATE
- NORVASC
