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Mezlocillin

Mezlocillin Struktur
51481-65-3
CAS-Nr.
51481-65-3
Bezeichnung:
Mezlocillin
Englisch Name:
Mezlocillin
Synonyma:
Melocin;Bay-f 1353;Melocillin;Multocillin;MEZLOCILLIN;Meslocillin;Meloxacam acid;Mezlocillin acid;Melocillin sodium;Meloxicillin acid
CBNumber:
CB9268151
Summenformel:
C21H25N5O8S2
Molgewicht:
539.58
MOL-Datei:
51481-65-3.mol

Mezlocillin Eigenschaften

Dichte
1.63±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
pka
pKa 2.7 (Uncertain)
CAS Datenbank
51481-65-3(CAS DataBase Reference)

Sicherheit

Mezlocillin Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Mezlocilin is an acylaminopenicillin, which has been shown to cause both immediate and delayed hypersensitivity in a nurse.

Verwenden

Like azlocillin, mezlocillin is used for infections of the urinary tract, gynecological infections, intraabdominal infections, skin infections, and respiratory tract infections. Synonyms of this drug are baypen, mezlin, and optocillin.

Definition

ChEBI: A penicillin in which the substituent at position 6 of the penam ring is a (2R)-2-[3-(methanesulfonyl)-2-oxoimidazolidine-1-carboxamido]-2-phenylacetamido group.

Antimicrobial activity

A semisynthetic acylureidopenicillin supplied as the sodium salt for parenteral administration.
Ampicillin-susceptible strains of H. influenzae and Neisseria spp. are very susceptible, but β-lactamase-producing organisms are usually resistant. It is less active than azlocillin and piperacillin against Ps. aeruginosa and has variable activity against B. fragilis, independent of β-lactamase production. It exhibits typical β-lactam synergy with aminoglycosides against Ps. aeruginosa and enterobacteria.
It attains peak concentrations of 250 mg/L after a 2 g intravenous infusion, with a plasma half-life of 55 min. Protein binding is 20–30%. It distributes into multiple tissues and human body fluids at therapeutically useful concentrations. Up to 60% of the dose is recoverable unchanged from the urine, with up to 2.5% excreted in the bile.
Toxicity and side effects are similar to those associated with carboxypenicillins. Its clinical use is for serious infections with susceptible organisms, including lower respiratory tract, intra-abdominal, urinary tract and gynecological infections. Commercial availability is quite limited.

Allgemeine Beschreibung

Mezlocillin was synthesized by Bayer in 1974. The NH2 residue of ampicillin was acylated. Mezlocillin is a member of the so-called ureidopenicillins and shows two- to eightfold greater activity against Citrobacter, Enterobacter, Klebsiella, Escherichia coli, and Haemophilus influenzae than ampicillin, carbenicillin, or sulbenicillin. Its activity against gram-positive bacteria is almost the same as that of carbenicillin. Mezlocillin is used by intravenous administration for therapy of sepsis, meningitis, and respiratory tract, urinary tract, and abdominal infections.

Mezlocillin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Mezlocillin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 138)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12834 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
HubeiwidelychemicaltechnologyCo.,Ltd
18627774460
faith@widelychemical.com CHINA 742 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
career henan chemical co
+86-0371-86658258 +8613203830695
factory@coreychem.com China 29811 58
SIMAGCHEM CORP
+86-13806087780
sale@simagchem.com China 17365 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167
1026@dideu.com China 7724 58

51481-65-3(Mezlocillin)Verwandte Suche:


  • (2s-(2-alpha,5-alpha,6-beta)(s*))-sodiumsal
  • 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylicacid,3,3-dimethyl-6-(((((3-(met
  • antibioticbay-f1353
  • 3,3-dimethyl-7-[[2-[(3-methylsulfonyl-2-oxo-imidazolidin-1-yl)carbonylamino]-2-phenyl-acetyl]amino]-6-oxo-2-thia-5-azabicyclo[3.2.0]heptane-4-carboxylic acid
  • Melocillin sodium
  • Meloxacam acid
  • Mezlocillin acid
  • MEZLOCILLIN SODIUM USP(CRM STANDARD)
  • 6α-[[(R)-[[[3-(Methylsulfonyl)-2-oxoimidazolidin-1-yl]carbonyl]amino]phenylacetyl]amino]penicillanic acid
  • Multocillin
  • Mezlocillin(Mezlocillin sodium)
  • MEZLOCILLIN
  • Mezlocillin Solution, 100ppm
  • (2S,5R,6R)-3,3-dimethyl-6-[[(2R)-2-[[(3-methylsulfonyl-2-oxo-1-imidazolidinyl)-oxomethyl]amino]-1-oxo-2-phenylethyl]amino]-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • 4-Thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 3,3-dimethyl-6-[[(2R)-2-[[[3-(methylsulfonyl)-2-oxo-1-imidazolidinyl]carbonyl]amino]-2-phenylacetyl]amino]-7-oxo-, (2S,5R,6R)-
  • Mezlocillin USP/EP/BP
  • Meloxicillin acid
  • Bay-f 1353
  • Melocin
  • Meslocillin
  • (2S,5R,6R)-3,3-Dimethyl-6-((R)-2-(3-(methylsulfonyl)-2-oxoimidazolidine-1-carboxamido)-2-phenylacetamido)-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid
  • Mezlocillin Sodium (sterile)
  • Melocillin
  • 51481-65-3
  • 51484-65-3
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