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Gemfibrozil

Gemfibrozil Struktur
25812-30-0
CAS-Nr.
25812-30-0
Bezeichnung:
Gemfibrozil
Englisch Name:
Gemfibrozil
Synonyma:
lopid;2,2-Dimethyl-5-(2,5-Dimethylphenoxy)Valeric;CI-7;Jezil;Genlip;C1-719;Lipttr;ci-719;Lipozid;Decrelip
CBNumber:
CB9154247
Summenformel:
C15H22O3
Molgewicht:
250.33
MOL-Datei:
25812-30-0.mol

Gemfibrozil Eigenschaften

Schmelzpunkt:
61-63°C
Siedepunkt:
158-159 C
Dichte
1.1109 (rough estimate)
Brechungsindex
1.5020 (estimate)
storage temp. 
2-8°C
L?slichkeit
Practically insoluble in water, very soluble in methylene chloride, freely soluble in anhydrous ethanol and in methanol.
Aggregatzustand
powder
pka
4.75±0.45(Predicted)
Farbe
White to Off-White
Wasserl?slichkeit
>0.5g/L(temperature not stated)
Merck 
14,4388
BCS Class
2
CAS Datenbank
25812-30-0(CAS DataBase Reference)
IARC
3 (Vol. 66) 1996
EPA chemische Informationen
Pentanoic acid, 5-(2,5-dimethylphenoxy)-2,2-dimethyl- (25812-30-0)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,Xi
R-S?tze: 22-63-62-46-36/38-21
S-S?tze: 36-53-36/37-26-25
WGK Germany  3
RTECS-Nr. YV7120000
HazardClass  IRRITANT
HS Code  2918992090
Giftige Stoffe Daten 25812-30-0(Hazardous Substances Data)
Toxizit?t LD50 in mice, rats (mg/kg): 3162, 4786 orally (Kurtz)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit

Gemfibrozil Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R63:Kann das Kind im Mutterleib m?glicherweise sch?digen.
R62:Kann m?glicherweise die Fortpflanzungsf?higkeit beeintr?chtigen.
R46:Kann vererbbare Sch?den verursachen.
R36/38:Reizt die Augen und die Haut.
R21:Gesundheitssch?dlich bei Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S25:Berührung mit den Augen vermeiden.

Beschreibung

Gemfibrozil is a peroxisome proliferator-activated receptor α (PPARα) and PPARγ agonist (EC50s = 193.3 and 147.8 μM, respectively, in transactivation assays). In vivo, gemfibrozil (50 mg/kg, p.o.) reduces serum total cholesterol, triglyceride, and LDL levels in a rat model of high-cholesterol diet-induced hyperlipidemia. Gemfibrozil (100 mg/kg per day) reduces atherosclerotic plaque area, superoxide production, and expression of the genes encoding the NF-κB subunit p65 and chemokine (C-C) motif ligand 2 (CCL2) in ApoE-/- mice. Formulations containing gemfibrozil have been used in the treatment of high cholesterol.

Chemische Eigenschaften

White Crystalline Powder

Verwenden

Gemfibrozil has been used to to study its effects on cell cycle progression in yeast. It has been used to study the effects of fibrates on cell proliferation and gene expression in human cell lines.

Weltgesundheitsorganisation (WHO)

Gemfibrozil, an antihyperlipidaemic derivative of clofibrate, was introduced in the early 1980's. It is registered in several countries for the treatment of hyperlipidaemia unresponsive to dietary measures. (See also the WHO comment for clofibrate).

Allgemeine Beschreibung

Gemfibrozil, 5-(2,5-dimethylphenoxy)-2,2-dimethylpentanoic acid (Lopid), is a congener of clofibratethat was used first in the treatment of hyperlipoproteinemia inthe mid-1970s. Its mechanism of action and use are similar tothose of clofibrate. Gemfibrozil reduces plasma levels ofVLDL triglycerides and stimulates clearance of VLDL fromplasma. The drug has little effect on cholesterol plasma levelsbut does cause an increase of HDL.
Gemfibrozil is absorbed quickly from the gut and excretedunchanged in the urine. The drug has a plasma half-life of1.5 hours, but reduction of plasma VLDL concentration takesbetween 2 and 5 days to become evident. The peak effect of its hypolipidemic action may take up to 4 weeks to becomemanifest.

Mechanism of action

From the chemical point of view, gemfibrozil is somewhat related to clofibrate and has analogous pharmacological use. The primary action of gemibrozil as well as clofibrate consists of a significant reduction in the level of very low-density proteins in the plasma and an increase in high-density protein formation.

Gemfibrozil Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Gemfibrozil Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 512)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Xiamen AmoyChem Co., Ltd
+86-86-5926051114 +8618959220845
sales@amoychem.com China 6383 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Longyan Tianhua Biological Technology Co., Ltd
0086 18039857276 18039857276
CHINA 2783 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
Hebei Zhanyao Biotechnology Co. Ltd
15369953316 +8615369953316
admin@zhanyaobio.com China 2123 58

25812-30-0(Gemfibrozil)Verwandte Suche:


  • PENTANOIC ACID, 5-(2,5-DIMETHYLPHENOXY)-2,2-DIMETHYL-
  • 5-(2,5-DIMETHYLPHYLPHENOXY)-2,2-DIMETHYLPENTANOIC ACID
  • 5-(2,5-DIMETHYL-PHENOXY)-2,2-DIMETHYL-PENTANOIC ACID
  • 2,2-DIMETHYL-5-[2,5-DIMETHYL-PHENOXY]PENTANOIC ACID
  • 2,2-DIMETHYL-5-(2,5-XYLYLOXY) VALERIC ACID
  • GEMFIBROZIL
  • Gemcitabine intermediates
  • 5-(2,5-Dimethylphenoxy)-2,2-dimethylpentanoic Acid, CI-719, Decrelip, Genlip, Gevilon, Lipozid, Lpur, Lopid
  • GEMFIBROZIL,USP
  • 5-(2,5-DIMETHYLPHENOXY)-2,2-DIMETHYLPENTANOICACID(GEMFIBROZIL)
  • CI-7
  • Decrelip
  • Genlip
  • Lipozid
  • 2,2-Dimethyl-5-(2,5-dimethyl phenoxy)pentoic acid
  • C1-719
  • Lipttr
  • 2,2-dimethyl-5-(2,5-xylyloxy)-valericaci
  • 5-(2,5-Dimethylphenoxy)-2,2-DimethylpentamoicAcid
  • 5-(2,5-dimethylphenoxy)-2,2-dimethyl-pentanoicaci
  • ci-719
  • 5-(2,5-dimethylphenoxy)-2,2-dimethyl-valeric acid
  • Gemfibrozil,2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic acid
  • Gemfibrozil (200 mg)
  • GeMfibrozil(Lopid)
  • GeMfibrozil Antipyrotic
  • 2,2-Dimethyl-5-(2,5-dimethylphenoxy)pentanoic Acid 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeric Acid
  • GEMFIBROZIL USP 26 98-102%
  • Gemfibrozil Capsules
  • Gemfibrozil for system suitability CRS
  • Gemfibrozil>
  • Gemfibrozil CRS
  • Jezil
  • 2,2-Dimethyl-5-(2,5-dimethylphenoxy)valeric Acid
  • Gemfibrozil USP/EP/BP
  • 2,2-Dimethyl-5-(2,5-zlyloxy)valeric acid (Gemfibrozil)
  • Gemfibrozil-d6Q: What is Gemfibrozil-d6 Q: What is the CAS Number of Gemfibrozil-d6 Q: What is the storage condition of Gemfibrozil-d6 Q: What are the applications of Gemfibrozil-d6
  • GemfibrozilQ: What is Gemfibrozil Q: What is the CAS Number of Gemfibrozil Q: What is the storage condition of Gemfibrozil Q: What are the applications of Gemfibrozil
  • Gemfibrozil (1288500)
  • 2,2-Dimethyl-5-(2,5-Dimethylphenoxy)Valeric
  • lopid
  • Giferrozzi
  • Gemfibrozil in methanol
  • C13999000 Gemfibrozil
  • 25812-30-0
  • C15H22O3
  • API
  • Antilipemic agent
  • Cardiovascular APIs
  • Intracellular receptor
  • LOPID
  • Active Pharmaceutical Ingredients
  • APIs
  • Bases & Related Reagents
  • Intermediates & Fine Chemicals
  • Nucleotides
  • Pharmaceuticals
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