1-BOC-Piperazine
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- CAS-Nr.
- 57260-71-6
- Englisch Name:
- 1-BOC-Piperazine
- Synonyma:
- 1-BOC-PIPERAZINE;BOC-PIPERAZINE;N-BOC-PIPERAZINE;PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;1-N-BOC-PIPERAZINE;1-(TERT-BUTOXYCARBONYL)PIPERAZINE;N-(TERT-BUTYLOXYCARBONYL)-PIPERAZINE;PIBOC;BOC-PAZ;N-Boc Piperizene
- CBNumber:
- CB8268275
- Summenformel:
- C9H18N2O2
- Molgewicht:
- 186.25
- MOL-Datei:
- 57260-71-6.mol
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1-BOC-Piperazine Eigenschaften
- Schmelzpunkt:
- 43-47 °C(lit.)
- Siedepunkt:
- 98-100
- Dichte
- 1.030±0.06 g/cm3(Predicted)
- Flammpunkt:
- >230 °F
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- L?slichkeit
- Soluble in DMSO
- pka
- 8.45±0.10(Predicted)
- Aggregatzustand
- Low Melting Crystalline Mass
- Farbe
- White to light yellow
- Wasserl?slichkeit
- Soluble in ethyl acetate, methanol and water.
- Sensitive
- Air Sensitive
- BRN
- 879985
- InChIKey
- CWXPZXBSDSIRCS-UHFFFAOYSA-N
- CAS Datenbank
- 57260-71-6(CAS DataBase Reference)
- NIST chemische Informationen
- T-butyl 1-piperaziencarboxylate(57260-71-6)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher |
Xi |
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R-S?tze: |
36/37/38 |
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S-S?tze: |
26-36 |
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RIDADR |
3263 |
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WGK Germany |
3 |
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F |
3-10-34 |
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HazardClass |
IRRITANT |
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HS Code |
29335995 |
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Bildanzeige (GHS) |
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Alarmwort |
Warnung |
Gefahrenhinweise |
Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
H315 |
Verursacht Hautreizungen. |
Hautreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P302+P352, P321,P332+P313, P362 |
H319 |
Verursacht schwere Augenreizung. |
Schwere Augenreizung |
Kategorie 2 |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
P264, P280, P305+P351+P338,P337+P313P |
H335 |
Kann die Atemwege reizen. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 3 (Atemwegsreizung) |
Warnung |
src="/GHS07.jpg" width="20" height="20" /> |
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Sicherheit |
P261 |
Einatmen von Staub vermeiden. |
P264 |
Nach Gebrauch gründlich waschen. |
P264 |
Nach Gebrauch gründlich waschen. |
P271 |
Nur im Freien oder in gut belüfteten R?umen verwenden. |
P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
P302+P352 |
BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen. |
P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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1-BOC-Piperazine Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Waxy Solid
Verwenden
1-Boc-piperazine undergoes Buchwald-Hartwig amination with various aryl halides to form corresponding amine derivatives. It can be used to synthesize monosubstituted piperazine intermediates of many bioactive molecules and piperazine containing drug substances, such as trazodone.
Application
Tert-Butyl 1-piperazinecarboxylate, also known as Olaparib Impurity 7, is an impurity of Olaparib. Olaparib is used alone or in combination with bevacizumab (Avastin) to help maintain the response of certain types of ovarian (female reproductive organs where eggs are formed), fallopian tube (tube that transports eggs released by the ovaries to the uterus), and peritoneal (layer of tissue that lines the abdomen) cancer in people who have completely responded or partially responded to their first or later chemotherapy treatments. Olaparib is also used to treat certain types of breast cancer that has spread to other parts of the body and has not improved or has worsened after treatment with other therapies. It is also used to treat certain types of early breast cancer in people who have already been treated with other chemotherapy treatments.
Allgemeine Beschreibung
1-Boc-piperazine is an
N-Boc protected piperazine. Crosscoupling of 1-Boc-piperazine with aryl iodides using CuBr/1,1′-bi-2-naphthol (catalyst) and K
3PO
4 (base) has been reported. 1-Boc-piperazine undergoes Buchwald-Hartwig coupling reactions with aryl halides. 1-Boc-piperazine can be prepared in 80% yield via solvent-free
N-Boc protection catalyzed by iodine.
1-BOC-Piperazine Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
1-BOC-Piperazine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 850)Lieferanten
57260-71-6()Verwandte Suche:
- 1-Boc-piperazine,99%
- 1-(tert-Butyloxycarbonyl)piperazine
- 1-Piperazinecarboxylic Acid 1,1-Dimethylethyl Ester
- 1-Piperazinecarboxylic Acid tert-Butyl Este
- N-(tert-Butoxycarbonyl)piperazine 98%
- Piperazine, N1-BOC protected
- tert-Butyl 2-piperazinecarboxylate
- N-(T-BUTYLOXYCARBONYL)-PIPERAZINE
- BUTTPARK 52\11-35
- BOC-PAZ
- 1-(tert-Butoxycarbonyl)piperazine~tert-Butyl 1-piperazinecarboxylate
- 1-BOC-PIPERAZINE, PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- 1-N-BOC-PIPERAZINE 99+%
- Piperazine, N1-BOC protected 98%
- 1-BOC-PIPERAZINE hydrochloride
- N-Boc-piperazine [N-(tert-Butoxycarbonyl)-piperazine]
- 1-Boc-piperazine >=98.0% (GC)
- 1-Boc-piperazine 97%
- N - bok - piperazine
- 1-Boc-piperazine≥ 99%(GC)
- tert-Butyl 1-piperazinecarboxyl
- N-Boc-piperazine hydrochloride
- 1-Boc-piperazine ,98%
- tert-Butyl 1-piperazinecarboxylate,97%
- tert-Butyl 1-piperazinecarboxylate,1-N-Boc-Piperazine
- 1-Boc-piperazine,tert-Butyl piperazine-1-carboxylate
- tert-butyl piperazine-1-carboxylate(SALTDATA: FREE)
- t-Butyl 1-piperazincarboxylate
- TERT-BUTYL N-PIPERAZINE
- TERT-BUTYL TETRAHYDROPYRAZINE-1(2H)-CARBOXYLATE
- TERT-BUTYL 1-PIPERAZINECARBOXYLATE
- RARECHEM AR PA 0026
- PIBOC
- N-(T-BOC)PIPERAZINE
- N-T-BUTOXYCARBONYLPIPERAZINE
- N-(TERT-BUTOXYCARBONYL)PIPERAZINE
- 1-[(1,1-DiMethylethoxy)carbonyl]piperazine
- 1-Piperazinecarboxylic Acid tert-Butyl Ester
- N-(tert-Butoxycarbonyl)piperazine, tert-Butyl piperazine-1-carboxylate
- tert-Butyl 1-piperazinecarboxylate, 97% 5GR
- tert-butyl piperazine-1-carbox
- 1,1-Dimethylethyl 1-piperazinecarboxylate
- Tert-Butyl 1-Piperazinecarboxylate1
- tert-Butyl 1-piperazincarboxylate
- 1-Boc-piperazine, 98%, for synthesis
- 1-(tert-Butoxycarbonyl)piperazine >
- Avatrombopag Impurity 28
- BOC-PAZ/1-Boc-piperazine
- tert-Butyl 1-piperazinecarboxylate ISO 9001:2015 REACH
- tert-butyl piperazine-1-carboylate
- Tertbutylpiperzine-1-carboxylate
(N-Boc-piperazine)
- t-BUTYL PIPERZINE-1-CARBOXYLATE
- CAS:57260-71-6 tert-Butyl 1-piperazinecarboxylate
- 1-BOC-Piperazine extrapure, 99%
- BOC-PIPERAZINE
- PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- N-BOC-PIPERAZINE
- N-(TERT-BUTYLOXYCARBONYL)-PIPERAZINE