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Aminophyllin

Aminophylline Struktur
317-34-0
CAS-Nr.
317-34-0
Bezeichnung:
Aminophyllin
Englisch Name:
Aminophylline
Synonyma:
aminophyllin;ethophylline;THEOPHYLLINE ETHYLENEDIAMINE;theomin;euufilin;grifomin;miofilin;theodrox;theolone;cardiomin
CBNumber:
CB8145350
Summenformel:
C9H16N6O2
Molgewicht:
240.27
MOL-Datei:
317-34-0.mol

Aminophyllin Eigenschaften

Schmelzpunkt:
269-270 °C
storage temp. 
Inert atmosphere,Store in freezer, under -20°C
L?slichkeit
H2O: 3.7 mg/mL solutions should be freshly prepared.
Aggregatzustand
powder
pka
pKa 5.0 (Uncertain)
Farbe
white to off-white
Wasserl?slichkeit
soluble
Merck 
14,465
InChI
InChI=1S/C7H8N4O2.C2H8N2/c1-10-5-4(8-3-9-5)6(12)11(2)7(10)13;3-1-2-4/h3H,1-2H3,(H,8,9);1-4H2
InChIKey
LHRHXWBJUQKYEL-UHFFFAOYSA-N
SMILES
O=C1N(C(=O)N(C)C2NC=NC1=2)C.C(N)CN
LogP
-0.175 (est)
CAS Datenbank
317-34-0(CAS DataBase Reference)
EPA chemische Informationen
1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1) (317-34-0)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,C
R-S?tze: 22-42/43-34-36/37/38-20/21/22
S-S?tze: 45-36/37/39-26-23-36
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS-Nr. XH5600000
10-23
TSCA  Yes
HazardClass  6.1(b)
PackingGroup  III
HS Code  29339900
Giftige Stoffe Daten 317-34-0(Hazardous Substances Data)
Toxizit?t LD50 orally in mice: 540 mg/kg (Thompson, Warren)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H301 Giftig bei Verschlucken. Akute Toxizit?t oral Kategorie 3 Achtung GHS hazard pictogramssrc="/GHS06.jpg" width="20" height="20" /> P264, P270, P301+P310, P321, P330,P405, P501
Sicherheit
P301+P310 BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

Aminophyllin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.
R34:Verursacht Ver?tzungen.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.

S-S?tze Betriebsanweisung:

S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Aminophylline is a 2/1 mixture of theophylline and ethylenediamine. It caused contact dermatitis in industrial plants, in pharmacists, and in nurses. Ethylenediamine is the sensitizer, and patch testing is generally positive to both ethylenediamine and aminophylline, but negative to theophylline.

Chemische Eigenschaften

white to slightly yellowish powder

Verwenden

Aminophylline is a bronchodilator and a non-selective phosphodiesterase (PDE) inhibitor.

Weltgesundheitsorganisation (WHO)

Aminophylline, the ethylenediamine salt of theophylline, was introduced many years ago as a treatment for asthma and is listed in the 8th WHO Model List of Essential Drugs. It has been recognized for some 10 years that aminophylline preparations are not interchangeable because bioavailability can vary considerably. The resulting variability in drug absorption can lead to adverse effects including irritation of the mucosa. Allergic reation can also be an adverse effect of aminophylline. Theophylline functions similarly but is considered less of an irritant.

Hazard

Cardiovascular and respiratory collapse.

Kontakt-Allergie

This drug is a 2:1 mixture of the alkaloid theophylline and ethylenediamine (see below). It caused contact dermatitis in industrial plants, pharmacists, and nurses. Ethylenediamine is the sensitizer and patch testing is generally positive to both ethylenediamine and aminophylline and negative to theophylline.

Aminophyllin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Aminophyllin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 546)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Ipure Biology Co., Ltd
+8613367258412
ada@ipurechemical.com China 10319 58
APOLLO HEALTHCARE RESOURCES
+6596580999
sales@apollo-healthcare.com.sg Singapore 399 58
Henan Suikang Pharmaceutical Co.,Ltd.
+86-18239973690 +86-18239973690
sales@suikangpharm.com China 311 58
Hebei Mojin Biotechnology Co., Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12835 58
shandong perfect biotechnology co.ltd
+86-53169958659 +86-13153181156
sales@sdperfect.com China 294 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Hebei Mojin Biotechnology Co.,Ltd
+86-15028179902
angelia@hbmojin.com China 1176 58
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
+8615350851019
admin@86-ss.com China 1001 58
Hebei Zhuanglai Chemical Trading Co Ltd
+86-16264648883 +86-16264648883
niki@zlchemi.com China 2691 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55

317-34-0(Aminophyllin)Verwandte Suche:


  • AMinophyllin Anhydrous USP
  • 3,9-dihydro-1,3-dimethyl-1H-purine-2,6-dione
  • Aminophylline dihydrochloride hyderate
  • Aminophylline, >=98%
  • (Theophylline)2 · Ethylenediamine 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, cmpd. with 1,2-ethanediamine (2:1) Theophylline hemiethylenediamine complex Theophylline, compound with ethylenediamine (2 to 1) dihydrate Theophylli
  • 3,7-dihydro-1,3-dimethyl-1h-purine-2,6-dionecompd.with1,2-ethanediamine(2
  • aminocadol
  • aminodur
  • vasofilina
  • 1H-Purine-2,6-dione, 3,7-dihydro-1,3-dimethyl-, compd. with 1,2-ethanediamine (2:1)
  • AMINOPHYLLINE,ANHYDROUS,POWDER,USP
  • Aminophlline Anhudrous
  • 13DIMETHYLXANTHINE-ETHYLENEDIAMINECOMPOUND
  • theophylline, compd. with ethylenediamine
  • AMINOPHYLLINE[3,7-DIHYDRO-1,3-DIMETHYL-1H-PURINE-2,6-DIONE]
  • (Theophylline)2 · Ethylenediamine
  • Theophylline, compound with ethylenediamine (2 to 1) dihydrate
  • theophylline--ethylenediamine (2:1)
  • AMINOPHYLLINE, PHARMA
  • 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione cmpd. with 1,2-ethanediamine (2:1)
  • 1h-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-,compdwith1,2-ethanediamine(2
  • Theophylline-ethylenediaMine anhydrous COS
  • (Theophylline)2 Ethylenediamine, Theophylline hemiethylenediamine complex, 3,7-Dihydro-1,3-dimethyl-1H-purine-2,6-dione, cmpd. with 1,2-ethanediamine (2:1)
  • Aminophylline,99%
  • Theophylline-e
  • AMINOPHYLLINE
  • THEOPHYLLINE COMPOUND WITH ETHYLENEDIAMINE
  • 1h-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-,compd.with1,2-ethanediamine
  • 1h-purine-2,6-dione,3,7-dihydro-1,3-dimethyl-,compd.with1,2-ethanediamine(
  • AMINOPHYLLINE, 99%, COMB. MIXT. OF THEOPHYLLINE AND ETHYLENEDIAMINE
  • Aminophullin
  • 1,3-diMethyl-1H-purine-2,6(3H,7H)-dione coMpound with ethane-1,2-diaMine (1:1)
  • Amminofillina
  • cardiofilina
  • cardophylin
  • cardophyllin
  • carena
  • cariomin
  • diophllin
  • diophyllin
  • diuxanthine
  • dobo
  • dura-tabs.m.aminophylline
  • dura-tabsmaminophylline
  • ethylenediamine,compd.withtheophylline(1:2)
  • etilen-xantisantabl
  • etilen-xantisantabl.
  • eufilina
  • euufillin
  • genophyllin
  • inophylline
  • lasodex
  • metaphyllin
  • metaphylline
  • minaphil
  • neophyiline
  • norofilina
  • peterphyllin
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