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Amoxicillin trihydrate

Amoxicillin trihydrate Struktur
61336-70-7
CAS-Nr.
61336-70-7
Englisch Name:
Amoxicillin trihydrate
Synonyma:
AMOXYCILLIN TRIHYDRATE;AMOXICILIN TRIHYDRATE;Amoxicillin trihydrate for performance verification CRS;Am 7;Amodex;A-Gram;Ardine;PeniMox;HelvaMox;AmoxiciL
CBNumber:
CB6690306
Summenformel:
C16H21N3O6S
Molgewicht:
383.42
MOL-Datei:
61336-70-7.mol

Amoxicillin trihydrate Eigenschaften

Schmelzpunkt:
>200°C (dec.)
alpha 
D20 +246° (c = 0.1)
Brechungsindex
302 ° (C=0.1, H2O)
storage temp. 
Inert atmosphere,2-8°C
L?slichkeit
Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in fatty oils. It dissolves in dilute acids and dilute solutions of alkali hydroxides.
Aggregatzustand
Solid
Farbe
White to Off-White
Wasserl?slichkeit
Soluble in water at 3.4mg/ml.
Merck 
14,577
JECFA Number
85
BRN 
7507120
CAS Datenbank
61336-70-7(CAS DataBase Reference)
EPA chemische Informationen
Amoxicillin trihydrate (61336-70-7)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,Xi
R-S?tze: 42/43
S-S?tze: 36-36/37-22
WGK Germany  2
RTECS-Nr. XH8300000
HS Code  29411000
Toxizit?t LD50 ipr-rat: 2870 mg/kg KSRNAM 7,3040,73
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H317 Kann allergische Hautreaktionen verursachen. Sensibilisierung der Haut Kategorie 1A Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H334 Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen. Sensibilisierung der Atemwege Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS08.jpg" width="20" height="20" /> P261, P285, P304+P341, P342+P311,P501
Sicherheit
P261 Einatmen von Staub vermeiden.
P272 Kontaminierte Arbeitskleidung nicht au?erhalb des Arbeitsplatzes tragen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P284 Atemschutz tragen.
P302+P352 BEI BERüHRUNG MIT DER HAUT: Mit viel Wasser/... (Hersteller kann, falls zweckm??ig, ein Reinigungsmittel angeben oder, wenn Wasser eindeutig ungeeignet ist, ein alternatives Mittel empfehlen) waschen.
P333+P313 Bei Hautreizung oder -ausschlag: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.

Amoxicillin trihydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R42/43:Sensibilisierung durch Einatmen und Hautkontakt m?glich.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S22:Staub nicht einatmen.

Beschreibung

Amoxicillin was synthesized by Beecham Research Laboratories in 1968. A hydroxyl group was introduced on the benzene ring of ampicillin. Amoxicillin shows about a twofold higher serum concentration than ampicillin when administered orally. It was shown by double-blind comparative studies with ampicillin that amoxicillin was as effective as ampicillin when administered at half the dose of ampicillin.

Chemische Eigenschaften

White to Off-White Solid

Verwenden

Amoxicillin trihydratesemi-synthetic antibiotic related to Penicillin which has antibacterial poperties. It is used for treatment of a variety of bacterial infections. It is used as a pharmaceutical product as a antibiotic agent, anti-infective drug raw materials.

Definition

ChEBI: A hydrate that is the trihydrate form of amoxicillin; a semisynthetic antibiotic, used either alone or in combination with potassium clavulanate (under the trade name Augmentin) for treatment of a variety of bacterial infections.

Kontakt-Allergie

Amoxicillin is both a topical and a systemic sensitizer. Topical sensitization occurs in health care workers. Systemic drug reactions are frequent, such as urticaria, maculo-papular rashes, baboon syndrome, acute generalized exanthematous pustulosis, or even toxic epidermal necrosis. Cross-reactivity is common with ampicillin, and can occur with other penicillins.

Sicherheitsprofil

Moderately toxic. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of SOx and NOx.

Amoxicillin trihydrate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Isooctans?ure Pivaloylchlorid Hydrogenchlorid Dichlormethan Propan-2-ol Ethyl-chlorformiat Wasserstoff 6-Aminopenicillansure Natriumhydrogencarbonat

Downstream Produkte

Natrium-[2S-[2α,5α,6β(S*)]]-6-[[amino(4-hydroxyphenyl)acetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptan-2-carboxylat

Amoxicillin trihydrate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 598)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd 		+8615531157085
 abby@weibangbio.com China 8806 58
Hebei Mujin Biotechnology Co.,Ltd 		+86 13288715578 +8613288715578
 sales@hbmojin.com China 12830 58
Wuhan Fortuna Chemical Co., Ltd 		+86-027-59207850
info@fortunachem.com China 5973 58
Hebei Kangcang new material Technology Co., LTD 		+8615713292910
 Nancy@kangcang.com.cn China 341 58
Shaanxi TNJONE Pharmaceutical Co., Ltd 		+8618092446649
 sarah@tnjone.com China 1143 58
Apeloa production Co.,Limited 		+8619933239880
 admin@apcl.com.cn China 861 58
Hebei Longbang Technology Co., LTD 		+86-18633929156 +86-18633929156
 admin@hblongbang.com China 966 58
Hebei Ganmiao New material Technology Co., LTD 		+86-17332992504 +86-17332992504
 sales8@hbganmiao.com China 300 58
BEIJING SJAR TECHNOLOGY DEVELOPMENT CO., LTD. 		+86-18600796368 +86-18600796368
 sales@sjar-tech.com China 484 58
Aurora Industry Co., Ltd. 		+86-13591747876 +86-13591747876
 alex1_auco@126.com China 299 58

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