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Methoxyfluran

methoxyflurane Struktur
76-38-0
CAS-Nr.
76-38-0
Bezeichnung:
Methoxyfluran
Englisch Name:
methoxyflurane
Synonyma:
MOZ;MOF;KAT8;hMOF;MYST1;KAT6A;MYST3;ZNF220;DA-759;RUNXBP2
CBNumber:
CB6314297
Summenformel:
C3H4Cl2F2O
Molgewicht:
164.97
MOL-Datei:
76-38-0.mol

Methoxyfluran Eigenschaften

Schmelzpunkt:
-36°C
Siedepunkt:
103 °C
Dichte
1.4262
Brechungsindex
1.386
Flammpunkt:
37°C
storage temp. 
-70°C
L?slichkeit
Chloroform (Sparingly)
Aggregatzustand
liquid
Farbe
Clear
Wasserl?slichkeit
Miscible with alcohol, acetone, chloroform, ether, fixed oils and benzene. Immiscible with water.
Merck 
14,5994
BRN 
1737766
Expositionsgrenzwerte
No exposure limit is set. Based on comparison with related compounds, a TLV-TWA of 675 mg/m3 (100 ppm) is recommended.
Stabilit?t:
Stability
CAS Datenbank
76-38-0(CAS DataBase Reference)
EPA chemische Informationen
Methoxyflurane (76-38-0)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi
R-S?tze: 10
S-S?tze: 23-24/25
RIDADR  3271
OEL Ceiling: 2 ppm (13.5 mg/m3) [60-minute] [*Note: REL for exposure to waste anesthetic gas.]
RTECS-Nr. KN7820000
Hazard Note  Irritant
HazardClass  3
PackingGroup  III
HS Code  2909191800
Giftige Stoffe Daten 76-38-0(Hazardous Substances Data)
Toxizit?t One of the most potent of the inhalational anesthetics, having a very high blood-gas partition coefficient and low vapor pressure at room temperature. Methoxyflurane is metabolized to a great extent (about 50-70%) in the liver and, as a consequence, there may be release of high concentrations of fluoride, sufficient to exceed the threshold for renal damage. Its use for sustained anesthesia is limited because of this renal toxicity and was discontinued around 1980.
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H226 Flüssigkeit und Dampf entzündbar. Entzündbare Flüssigkeiten Kategorie 3 Warnung
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H341 Kann vermutlich genetische Defekte verursachen. Keimzellmutagenit?t Kategorie 2 Warnung P201,P202, P281, P308+P313, P405,P501
Sicherheit
P210 Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen.
P241 Explosionsgeschützte [elektrische/Lüftungs-/ Beleuchtungs-/...] Ger?te verwenden.

Methoxyfluran Chemische Eigenschaften,Einsatz,Produktion Methoden

ERSCHEINUNGSBILD

FARBLOSE FLüSSIGKEIT MIT CHARAKTERISTISCHEM GERUCH.

CHEMISCHE GEFAHREN

Zersetzung beim Verbrennen unter Bildung giftiger Rauche (Chlorwasserstoff, Fluorwasserstoff). Greift einige Arten von

ARBEITSPLATZGRENZWERTE

TLV nicht festgelegt (ACGIH 2005).
MAK nicht festgelegt (DFG 2006).

AUFNAHMEWEGE

Aufnahme in den K?rper durch Inhalation der D?mpfe.

INHALATIONSGEFAHREN

Nur ungenügende Angaben vorhanden über die Geschwindigkeit, mit der eine gesundheitssch?dliche Konzentration in der Luft beim Verdampfen bei 20°C erreicht wird.

WIRKUNGEN BEI KURZZEITEXPOSITION

WIRKUNGEN BEI KURZZEITEXPOSITION:
Exposition in hohen Konzentrationen kann zu Bewusstlosigkeit führen.

WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

M?glich sind Auswirkungen auf Nieren mit nachfolgenden Nierensch?den.

LECKAGE

Pers?nliche Schutzausrüstung: Atemschutzfilter für organische Gase und D?mpfe. Ausgelaufene Flüssigkeit in abdichtbaren Metallbeh?ltern sammeln. Reste mit Sand oder inertem Absorptionsmittel aufnehmen und an einen sicheren Ort bringen.

R-S?tze Betriebsanweisung:

R10:Entzündlich.

S-S?tze Betriebsanweisung:

S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

colourless liquid

Verwenden

Methoxyflurane is a very potent and highly lipid soluble anesthetic agent. Methoxyflurane causes deep sedation and it has been used as a patient controlled analgesic for painful procedures in children. Methoxyflurane is a significant respiratory depressant.

Definition

ChEBI: An ether in which the two groups attached to the central oxygen atom are methyl and 2,2-dichloro-1,1-difluoroethyl.

Biologische Funktion

Methoxyflurane (Penthrane) is the most potent inhalational agent available, but its high solubility in tissues limits its use as an induction anesthetic. Its pharmacological properties are similar to those of halothane with some notable exceptions. For example, since methoxyflurane does not depress cardiovascular reflexes, its direct myocardial depressant effect is partially offset by reflex tachycardia, so arterial blood pressure is better maintained. Also, the oxidative metabolism of methoxyflurane results in the production of oxalic acid and fluoride concentrations that approach the threshold of causing renal tubular dysfunction. Concern for nephrotoxicity has greatly restricted the use of methoxyflurane.

Allgemeine Beschreibung

Methoxyflurane is a volatile liquid (bp=105°C) with a highblood:gas partition coefficient and thus a slow induction andprolonged recovery. Approximately 75% of the drug undergoesmetabolism yielding dichloroacetate, difluoromethoxyacetate,oxalate, and fluoride ions. The intrarenal inorganicfluoride concentration, as a result of renal defluorination, maybe responsible for the nephrotoxicity seen with methoxyflurane.Both the concentration of F- generated and the durationfor which it remained elevated were factors in the developmentof methoxyflurane nephrotoxicity. Methoxyfluranewas removed from the U.S. market in 2000 because of saferalternatives. Both isoflurane and enflurane produce less fluorideion upon metabolism than methoxyflurane.

Air & Water Reaktionen

Insoluble in water.

Reaktivit?t anzeigen

2,2-DICHLORO-1,1-DIFLUOROETHYL METHYL ETHER may be sensitive to prolonged exposure to light.

Health Hazard

Methoxyflurane exhibited low to very lowacute toxicity via inhalation, slightly lowerthan that of ethrane. Oral toxicity was low tomoderate depending on the species. Inhala tion of its vapors at 1.5–2% by volumeconcentrations in air can cause anesthesia inhumans. The toxic symptoms are similar tothose of ethrane, and the target organs areprimarily the central nervous system, kidney,and liver. At subanesthetic concentrations of0.3–0.5% by volume in air, its exposure tohumans for 1 hour resulted in the onset oflow toxicity. The sites of biological effectswere in the kidney.
LC50 value, inhalation (mice): 17,500 ppm/2 hr
LD50 value, oral (mammals): 3600 mg/kg
The liquid may be an irritant to theeyes. The teratomeric properties of this com pound were observed in rats and mice. Thesymptoms were embryo deaths and develop mental abnormalities in the urogenital andmusculoskeletal systems.
No carcinogenic actions in animals orhumans have been reported. The histidinereversion–Ames test for mutagenicity wasinconclusive.

Brandgefahr

2,2-DICHLORO-1,1-DIFLUOROETHYL METHYL ETHER is combustible.

Clinical Use

Methoxyflurane is seldom used because of its propensity to cause renal toxicity. It is the most potent agent, and it has the highest solubility in blood. Induction and recovery would be expected to be slow. Chemically, it is rather unstable, and as much as 50% of an administered dose can be metabolized. Toxic metabolites significantly limit its utility as a general anesthetic.

Methoxyfluran Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Methoxyfluran Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 90)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Career Henan Chemica Co
+86-0371-86658258 +8613203830695
laboratory@coreychem.com China 30239 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
ANHUI WITOP BIOTECH CO., LTD
+8615255079626
eric@witopchemical.com China 23541 58
CD Chemical Group Limited
+8615986615575
info@codchem.com China 20342 58
Shaanxi Didu New Materials Co. Ltd
+86-89586680 +86-13289823923
1026@dideu.com China 8670 58
SUZHOU SENFEIDA CHEMICAL CO.,LTD
+86-0512-83500002 +8615195660023
sales@senfeida.com China 23046 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501
product@acmec-e.com China 33338 58
Shanghai Likang New Materials Co., Limited
+86-16631818819 +86-17736933208
3684455296@qq.com China 9300 58
SHANGHAI KEAN TECHNOLOGY CO., LTD.
+8613817748580
cooperation@kean-chem.com China 40066 58

76-38-0(Methoxyfluran)Verwandte Suche:


  • RUNXBP2
  • ZNF220
  • Anti-MYST1 antibody produced in rabbit
  • MOZ
  • MYST protein 1
  • SAS2 and TIP60 protein 1
  • YBF2/SAS3
  • ANTI-HMOF/MYST1(C-TERMINAL) antibody produced in rabbit
  • Histone acetyltransferase KAT8
  • KAT8
  • Lysine acetyltransferase 8
  • MYST1
  • 1,1-dichloro-2,2-difluoro-2-methoxyethane
  • 2,2-dichloro-1,1-difluoro-1-methoxy-ethan
  • Methoxyflurane, 2,2-Dichloro-1,1-difluoro-1-methoxyethane
  • Methoxyflurane (1 mL)
  • 2,2-DICHLORO-1,1-DIFLUOROETHYL METHYL ETHER
  • 1,1-difluoro-2,2-dichloroethyl methyl ether
  • Methflurane
  • Methoxflurane
  • METHOXYFLURANE (METOFANE)
  • ether,2,2-dichloro-1,1-difluoroethylmethyl
  • Ingalan
  • Inhalan
  • Methofane
  • Methoflurane
  • Methoxane
  • Methoxiflurane
  • Methoxyfluoran
  • Methoxyfluorane
  • Methoxyfluran
  • Methyl 1,1-difluoro-2,2-dichloroethyl ether
  • Metoxfluran
  • Metoxifluran
  • MOF
  • NSC-110432
  • Penthrane
  • Pentrane
  • METHOXYFLURANE
  • METOFANE
  • Methoxyflurane (2,2-Dichloro-1,1-difluoroethyl methyl ether)
  • Metofane (2,2-Dichloro-1,1-difluoroethyl methyl ether)
  • 2,2-Dichloro-1,1-difluoroethyl methyl ether 96%
  • 2,2-Dichloro-1,1-difluoro-1-methoxyethane
  • 2-methoxyethane,1,1-dichloro-2,2-difluoro-
  • Analgizer
  • Anecotan
  • DA-759
  • Ethane, 2,2-dichloro-1,1-difluoro-1-methoxy-
  • Ether, 2,2-dichloro-1,1-difluoroethyl methyl
  • 2,2-Dichloro-1,1-difluoroethylmethylether96%
  • METHOXYFLUORENE
  • 1-Methoxy-1,1-difluoro-2,2-dichloroethane
  • 2,2-Dichloro-1,1-difluoro-1-methoxyethane, 1,1-Dichloro-2,2-difluoro-3-oxabutane
  • FLJ14040
  • KAT8 (2-467), GST tagged human
  • hMOF
  • Monoclonal Anti-MYST1 antibody produced in mouse
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