成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

Sucralfat

Sucralfate Struktur
54182-58-0
CAS-Nr.
54182-58-0
Bezeichnung:
Sucralfat
Englisch Name:
Sucralfate
Synonyma:
SUCRALPHATE;carafate;Keal;Ulcar;Urbal;Sugast;Venter;Citogel;Succosa;Sucrate
CBNumber:
CB6239042
Summenformel:
C11H52Al16O75S8-16
Molgewicht:
2072.71
MOL-Datei:
54182-58-0.mol

Sucralfat Eigenschaften

Schmelzpunkt:
>220°C (dec.)
Siedepunkt:
1990℃ at 101.325kPa
Dichte
0.338 at 20℃
Dampfdruck
0Pa at 25℃
storage temp. 
Inert atmosphere,2-8°C
L?slichkeit
Practically insoluble in water, in ethanol (96 per cent) and in methylene chloride. It dissolves in dilute solutions of mineral acids and alkali hydroxides.
pka
pKa = 0.43 to 1.19(at 25℃)
Aggregatzustand
Solid
Farbe
White
LogP
1.46 at 25℃ and pH7

Sicherheit

WGK Germany  2
RTECS-Nr. BD0900000
HS Code  29400090
Giftige Stoffe Daten 54182-58-0(Hazardous Substances Data)

Sucralfat Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Sucralfate is a complex of the sulfuric acid ester of sucrose and aluminum hydroxide. Secondary polymerization with aluminum hydroxide forms intermolecular bridges between molecules of sulfate esters with aluminum. Limited dissociation of the complex occurs in gastric acid, but these anionic sulfate esters form insoluble adherent complexes with the proteinaceous exudate at the abraded surface of a crater of the ulcerated area in the stomach. This physical complex protects the ulcer from the erosive action of pepsin and bile salts. Sucralfate also stimulates synthesis and release of prostaglandins, bicarbonate, and epidermal and fibroblast growth factors. Significant ulcer healing effects are noted in placebo-controlled trials. Only small amounts of sucralfate are absorbed systemically. In renal impairment, there is a risk of accumulation of absorbed aluminum from the drug. Sucralfate reduces absorption of other drugs, including H2 antihistamines, quinolone antibiotics, phenytoin, and perhaps, warfarin

Chemische Eigenschaften

White Powder

Verwenden

Sucralfate, an aluminum salt of sucrose octasulfate, is used as an antacid and antiulcer medication. Bis- and tris-platinum complexes of sucrose show promise as antitumor agents. Sucrose monoesters are used in some pharmaceutical preparations.

Indications

Sucralfate (Carafate) is an aluminum hydroxide–sulfated sucrose complex that is only minimally absorbed from the GI tract. After exposure to gastric acid, the compound becomes negatively charged, creating a viscous adherent complex. This complex is believed to inhibit back-diffusion of H .Other effects are a direct reduction in pepsin activity and a slight rise in tissue prostaglandin levels. Stimulation of a cytoprotection mechanism may therefore assist mucosal healing. The drug has no acid-buffering capacity.

Allgemeine Beschreibung

Sucralfate, 3,4,5,6-tetra-(polyhydroxyaluminum)-α-D-glucopyranosyl sulfate-2,3,4,5-tetra-(polyhydroxyaluminum)-β-D-fructofuranoside sulfate (Carafate), isthe aluminum hydroxide complex of the octasulfate ester ofsucrose. It is practically insoluble in water and soluble instrong acids and bases. It has a pKa value between 0.43 and1.19.
Sucralfate is minimally absorbed from the GI tract by design,and thus exerts its antiulcer effect through local ratherthan systemic action. It has negligible acid-neutralizing orbuffering capacity in therapeutic doses. Although its mechanismof action has not been established, studies suggestthat sucralfate binds preferentially to the ulcer site to form aprotective barrier that prevents exposure of the lesion to acidand pepsin. In addition, it adsorbs pepsin and bile salts.Either would be very desirable modes of action.
The simultaneous administration of sucralfate may reducethe bioavailability of certain agents (e.g., tetracycline, phenytoin,digoxin, or cimetidine). It further recommends restorationof bioavailability by separating administration of theseagents from that of sucralfate by 2 hours. Presumably, sucralfatebinds these agents in the GI tract. The most frequentlyreported adverse reaction to sucralfate is constipation (2.2%).Antacids may be prescribed as needed but should not be takenwithin 0.5 hour before or after sucralfate.

Clinical Use

Sucralfate is frequently used for prophylaxis of stress-induced gastritis in patients in intensive care units. It has also been successfully used in small numbers of patients as a suspension enema to treat radiation proctitis.

Sucralfat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Sucralfat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 277)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8810 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Apeloa production Co.,Limited
+8619933239880
admin@apcl.com.cn China 852 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
SHANDONG ZHI SHANG CHEMICAL CO.LTD
+86 18953170293
sales@sdzschem.com China 2930 58
Shaanxi Pioneer Biotech Co., Ltd .
+8613259417953
sales@pioneerbiotech.com China 1287 58
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
Shanghai Longyu Biotechnology Co., Ltd.
+8619521488211
info@longyupharma.com China 2541 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58

54182-58-0(Sucralfat)Verwandte Suche:


  • ALUMINUM SUCROSE OCTASULFATE
  • Sucrose Octasulfate Aluminium Salt
  • SUCRALFATE,FINEPOWDER
  • SUCRALFATE,FINEPOWDER,USP
  • SUCRALFATE TABLETS
  • SUCROSE OCTASULFATE - ALUMINUM COMPLEX
  • SUCRALFATE
  • beta-d-fructofuranosyl-alpha-d-glucopyranoside octakis-(hydrogen sulfate) aluminum
  • SUCRALFATE ( MICRONIZED )
  • Hexadeca--hydroxytetracozahydroxy[8-[1,3,4,6-tetra-O-sulpho--D-fructofuranozyl a-D-glucopyranozide tetrax (hydrosulphate(8-)hexadecaaluminum
  • Antepsin
  • Sucrose hydrogen sulfate basic aluminium salt
  • Sucralfate (Sucrose octasulfate-aluminum complex)
  • Sucralfate (FDA)
  • Citogel
  • Hexagastron
  • Keal
  • Succosa
  • Sucralfin
  • Sucrate
  • Sugast
  • Sulcrate
  • Ulcar
  • Urbal
  • hexadeca-u-hydroxytetracosahydroxy-[u8-[1,3,4,6-tetra-o-sulfo-beta-d-fructofur
  • numcomplex
  • sucroseoctakis(hydrogensulfate)aluminumcomplex
  • ulcerban
  • ulcerlmin
  • ulcogant
  • Venter
  • Sucralfate USP
  • AluMinuM,hexadeca-M-hydroxytetracosahydroxy[M8-[[1,3,4,6-tetra-O-sulfo-b-D-fructofuranosyl a-D-glucopyranosidetetrakis(sulfato-kO')](8-)]]hexadeca-
  • )hexadeca-
  • aluminum,hexadeca-u-hydroxytetracosahydroxy(mu8-(1,3,4,6-tetra-o-sulfo-beta-d
  • anosyl-alpha-d-glucopyranosidetetrakis(hydrogensulfato)(8-)]]hexadecaaluminu
  • beta-d-fructofuranosyl-alpha-d-glucopyranosideoctakis-(hydrogensulfate)alumi
  • beta-d-fructofuranosyl-alpha-d-glucopyranosidetetrakis(hydrogensulfato)(8-))
  • -fructofuranosylalpha-d-glucopyranosidetetrakis(hydrogensulfato)(8-)))hexade
  • hexadeca-mu-hydroxytetracosahydroxy(mu(sup8)-(1,3,4,6-tetra-o-sulfo-aluminu
  • [(2R,3R,4S,5R,6R)-2-[[(2R,3R,4S,5S)-3,4-bis($l^{1}-alumanyloxysulfonyloxy)-2,5-bis($l^{1}-alumanyloxysulfonyloxymethyl)-2-oxolanyl]oxy]-3,5-bis($l^{1}-alumanyloxysulfonyloxy)-6-($l^{1}-aluma
  • Sucralfate (Technical Grade)
  • Sucralfate CRS
  • Sucralfate USP/EP/BP
  • Antiacid
  • Sucrose Octasulphate Aluminium Salt (Sucralfate) extrapure
  • SUCRALPHATE
  • carafate
  • Hexadeca-μ-hydroxytetracosahydroxy[μ8-[[1,3,4,6-tetra-O-sulfo-β-D-fructofuranosyl α-D-glucopyranoside tetrakis(sulfato-κO′)](8-)]]hexadecaaluminum
  • Vancomycin hydrochloride 1404-93-9
  • 54182-58-0
  • 156-2-78
  • C11H52Al16O75S816
  • C12H30Al8O51S88H3AlO3
  • C12H54Al16O75S8
  • C12H14O11R8
  • C12H14O35S8
  • C11H60Al9O55S8
Copyright 2019 ? ChemicalBook. All rights reserved