成人免费xx,国产又黄又湿又刺激不卡网站,成人性视频app菠萝网站,色天天天天

5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron

Genistein Struktur
446-72-0
CAS-Nr.
446-72-0
Bezeichnung:
5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron
Englisch Name:
Genistein
Synonyma:
Licoisoflavone;5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-chromen-4-one;GEN;GENESTEIN;Bonistein;prunetol;GeniVida;G2535;BIO-00;BIO300
CBNumber:
CB6163787
Summenformel:
C15H10O5
Molgewicht:
270.24
MOL-Datei:
446-72-0.mol

5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron Eigenschaften

Schmelzpunkt:
297-298 °C
Siedepunkt:
333.35°C (rough estimate)
Dichte
1.2319 (rough estimate)
Brechungsindex
1.6000 (estimate)
storage temp. 
-20°C
L?slichkeit
DMSO: soluble
Aggregatzustand
powder
pka
6.51±0.20(Predicted)
Farbe
off-white
Wasserl?slichkeit
insoluble
Merck 
14,4391
BRN 
263823
Stabilit?t:
Light Sensitive
InChIKey
TZBJGXHYKVUXJN-UHFFFAOYSA-N
LogP
3.114 (est)
CAS Datenbank
446-72-0(CAS DataBase Reference)
EPA chemische Informationen
4H-1-Benzopyran-4-one, 5,7-dihydroxy-3-(4-hydroxyphenyl)- (446-72-0)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi,Xn
R-S?tze: 36/38-22
S-S?tze: 26-24/25-22
WGK Germany  3
RTECS-Nr. NR2392000
TSCA  Yes
HazardClass  IRRITANT
HS Code  29329990
Giftige Stoffe Daten 446-72-0(Hazardous Substances Data)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R36/38:Reizt die Augen und die Haut.

S-S?tze Betriebsanweisung:

S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S22:Staub nicht einatmen.

Chemische Eigenschaften

Yellow Crystalline Solid

Verwenden

Exhibits specific inhibitory activity against tyrosine kinases,including autophosphorylation of epidermal growth factor receptor kinase (IC50 - 2.6uM). Also inhibits other protein kinases through competitive inhibition of ATP. Inhibits tumor cell proliferation and induces tumor cell differentiation. Produces cell-cycle arrest and apoptosis in Jurat T-leukemia cells. However, it prevents anti-CD3 monoclonal antibody-induced thymic apoptosis. Genistein also inhibits topoisomerase II activity in vitro. Genistein has also been shown to inhibit the action of GABA on recombinant GABAA receptors 2. uv(max)ethanol: 262.5 nm (e= 138). moderately sol. in hot alcohol

Definition

ChEBI: 7-Hydroxyisoflavone with additional hydroxy groups at positions 5 and 4'. It is a phytoestrogenic isoflavone with antioxidant properties.

Allgemeine Beschreibung

Pharmaceutical secondary standards for application in quality control provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards

Biologische Aktivit?t

Phytoestrogen with a wide range of biological actions. Inhibits protein tyrosine kinases including epidermal growth factor receptor kinase. Also binds to PPAR γ and estrogen receptors and acts as an agonist at GPR30. Also available as part of the MAPK Cascade Inhibitor Tocriset™ .

Mechanism of action

Genistein, an isoflavone isolated from soybeans, exhibits anticarcinogenic and antioxidant properties. Particularly, genistein has been shown to inhibit production of IL-6 and MAPK. Modulation to these cellular events may help regulate and attenuate UVB-induced inflammatory damage to the skin. Moreover, genistein inhibits UV-induced oxidative DNA damage and blocks UV-induced expression of c-fos and c-jun proto-oncogenes.

Anticancer Research

It is an isoflavone and is obtained from a variety of plants like psoralea (Psoraleacorylifolia), kudzu (Pueraria lobata), faba beans (Vicia faba), and soybeans(Glycine max). It exhibits anticancer effect by inhibiting NF-κB and protein kinaseB (Akt) signaling pathways (Singh et al. 2016b). It blocks the proliferation of cancercells via the inhibition of cell growth enzymes and survival like tyrosine kinase andtopoisomerase II; hence it is used to treat leukemia. Genistein increases the growthrate of some estrogen receptors in breast cancer cells and the rate of proliferation of estrogen-dependent breast cancer by competitive binding to the estrogen-β receptors.It may be involved in JNK pathway in inducing activator protein-1(AP-1) activity(Wang et al. 2012; Dixon and Ferreira 2002).

Sicherheitsprofil

Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

l?uterung methode

Crystallise it from EtOH or aqueous EtOH. It has UV: max at 290nm (EtOH). The S(-)-enantiomer (natural form) has m 255-256o (from EtOH) and [] D 20 -28.0o (c 2, EtOH), [ ] D 20 -35.2o (c 1, pyridine).[Beilstein 18 H 503, 18 II 164, 18 III/IV 2630.] Genistein (4',5,7-trihydroxyisoflavone) [446-72-0]M 270.2 crystallises from 60% aqueous EtOH or water with m 297-298o and [] D 20 -28o (c 0.6, 20mM NaOH). [Beilstein 18/4 V 594.]For Naringin (naringenin 7-rhamnoglucoside) See “Carbohydrates” in Chapter 6.

5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 729)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Chengdu ChenLv Herb Co.,Ltd
+86-13608205856; +undefined13608205856
maryextract@126.com China 127 58
Bonerge(Hunan) Lifescience Co., Ltd.
+86-731-82791134 +86-17673622440
Alav.w@bonerge.com China 30 58
Hebei Kingfiner Technology Development Co.Ltd
+86-15532196582 +86-15373005021
lisa@kingfinertech.com China 3010 58
Wuhan Quanjinci New Material Co.,Ltd.
+86-15271838296; +8615271838296
kyra@quanjinci.com China 1512 58
Chongqing Zhihe Biopharmaceutical Co., Ltd.
+86-18580541567; +8618580541567
sales@zhswyy.com China 301 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20284 58
BINBO BIOLOGICAL CO.,LTD
+8618629063126
info@binbobiological.com China 423 58
Hebei Zhuanglai Chemical Trading Co Ltd
+86-16264648883 +86-16264648883
niki@zlchemi.com China 2691 58
Capot Chemical Co.,Ltd.
+86-(0)57185586718 +86-13336195806
sales@capot.com China 29791 60
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886
info@dakenam.com China 18751 58

446-72-0(5,7-Dihydroxy-3-(4-hydroxyphenyl)-4-benzopyron)Verwandte Suche:


  • Genistein >98%
  • Genistein, 98% (4’,5,7-Trihydroxyisoflavone)
  • Genisteol&Prunetol
  • Genistein (C.I. 75610)
  • 4H-1-Benzopyran-4-one,5,7-dihydroxy-3-
  • Baichanin A
  • Genistein ,99%
  • GENISTEIN, 99%, SYNTHETIC
  • 4μ,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
  • Genista tinctoria Linn
  • 5,7-Trihydroxyisof
  • Bio1_000445
  • BRN 0263823
  • BSPBio_002375
  • CCRIS 7675
  • cMAP_000086
  • EINECS 207-174-9
  • EU-0100520
  • G6776_SIGMA
  • KBio2_002564
  • KBio2_005132
  • KBio2_007700
  • KBio3_001595
  • NCGC00025005-02
  • nchembio.76-comp6
  • NSC 36586
  • SIPI 807-1
  • SPBio_000636
  • Spectrum2_000638
  • Spectrum3_000678
  • Spectrum5_000106
  • 5-18-04-00594 (Beilstein Handbook Reference)
  • Genistein ( or 4',5,7-Trihydroxyisoflavone)
  • Genistein, Soybean
  • 4’,5,7-trihydroxy-isoflavon
  • sophoricol
  • 4',5,7-TRIHYDROXYISOFLAVONE
  • 5,7,4'-TRIHYDROXYISOFLAVONE
  • 5,7-DIHYDROXY-3-(4-HYDROXYPHENYL)-4H-1-BENZOPYRAN-4-ONE
  • 5,7-DIHYDROXY-3-(4-HYDROXY-PHENYL)-CHROMEN-4-ONE
  • AKOS NCG1-0029
  • GENISTEIN
  • 5,7-dihydroxy-3-(4-hydroxyphenyl)-4-benzopyrone
  • GENISTEIN RESEARCH GRADE
  • Genistein,4′,5,7-Trihydroxyisoflavone, 5,7-Dihydroxy-3-(4-hydroxyphenyl)-4H-1-benzopyran-4-one
  • GLYCITEN
  • Bonistein TG
  • Genistein (15 mg)
  • Golden sparrow isoflavone
  • NPI 031L
  • Genistein, synthetic, 99% 25MG
  • Genistein SynonyMs 4',5,7-Trihydroxyisoflavone
  • Genistein 0.25
  • 5,7-dihydroxy-3-(4-hydroxyphenyl)-4h-1-benzopyran-4-on
  • c.i.75610
  • differenola
  • genistein(synthetic)
  • genisteol
Copyright 2019 ? ChemicalBook. All rights reserved