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Diltiazem

Diltiazem Struktur
42399-41-7
CAS-Nr.
42399-41-7
Bezeichnung:
Diltiazem
Englisch Name:
Diltiazem
Synonyma:
DILTIAZEN;Dilthiazem;(2S,3S)-5-(2-(diMethylaMino)ethyl)-2-(4-Methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate;Coras;NSC7324;NSC 7324;NSC-7324;DILTIAZEM;Adizem XL;d-Diltiazem
CBNumber:
CB5715839
Summenformel:
C22H26N2O4S
Molgewicht:
414.52
MOL-Datei:
42399-41-7.mol

Diltiazem Eigenschaften

Schmelzpunkt:
212 °C (decomp)
Siedepunkt:
594.4±50.0 °C(Predicted)
Dichte
1.26±0.1 g/cm3(Predicted)
storage temp. 
-20°C Freezer
L?slichkeit
Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka
pKa 7.70 (Uncertain)
Aggregatzustand
Solid
Farbe
White to Off-White
CAS Datenbank
42399-41-7(CAS DataBase Reference)
NIST chemische Informationen
Diltiazem(42399-41-7)
EPA chemische Informationen
1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)- (42399-41-7)

Sicherheit

Giftige Stoffe Daten 42399-41-7(Hazardous Substances Data)

Diltiazem Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Diltiazem is a potent vasodilator compound. Antihypertensive.

Definition

ChEBI: A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the m nagement of angina pectoris and hypertension.

Mechanism of action

Diltiazem reduces the transmembrane influx of calcium ions into cells of cardiac muscle and smooth musculature of vessels. It causes dilation of coronary and peripheral vessels, increases coronary blood flow, and prevents development of coronary artery spasms. It lowers elevated arterial pressure and reduces tachycardia.

Clinical Use

The antiarrhythmic actions and uses of diltiazem are similar to those of verapamil. Diltiazem is effective in controlling the ventricular rate in patients with atrial flutter or atrial fibrillation.

Diltiazem Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Essigs?ureanhydrid Hydrogenchlorid 2-Aminobenzolthiol Ethyl-chloracetat Natriumethanolat Natriumhydrogencarbonat Anisaldehyd Diltiazem hydrochloride Ethyl 4-methoxycinnamate (αS,βS)-β-[(2-AMinophenyl)thio]-α-hydroxy-4-Methoxybenzenepropanoic Acid Methyl Ester (2S-cis)-5-[2-(Dimethylamino)ethyl]-2,3-dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-on (2S-cis)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-on 4-Iodanisol 2-Chlorethyldimethylammonium-chlorid

Downstream Produkte

Diltiazem Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 158)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Mujin Biotechnology Co.,Ltd 		+86 13288715578 +8613288715578
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 bess@weibangbio.com China 18148 58
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 angelia@hbmojin.com China 1175 58
Hebei Ganmiao New material Technology Co., LTD 		+86-17332992504 +86-17332992504
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 FandaChem@Gmail.com China 8771 55
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Shenzhen Nexconn Pharmatechs Ltd 		+86-755-89396905 +86-15013857715
 admin@nexconn.com China 10311 58
Cangzhou Wanyou New Material Technology Co.,Ltd 		18631714998
sales@czwytech.com CHINA 904 58
Shanghai Longyu Biotechnology Co., Ltd. 		+8619521488211
 info@longyupharma.com China 2558 58

42399-41-7(Diltiazem)Verwandte Suche:

  • (+)-5-[2-(Dimethylamino)ethyl]-cis-2,3-dihydro-3-hydroxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one acetate (ester)
  • (2s-cis)-dro-2-(4-methoxyphenyl)
  • (2S,3S)-2,3-Dihydro-2-(4-methoxyphenyl)-3-hydroxy-5-[2-(dimethylamino)ethyl]-1,5-benzothiazepine-4(5H)-one acetate
  • (2R)-3α-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2α-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
  • [2R,(+)]-3α-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2α-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
  • 3α-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2α-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
  • 3α-Acetyloxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2α-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
  • [(2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] acetate
  • [(2S,3S)-5-(2-dimethylaminoethyl)-2-(4-methoxyphenyl)-4-oxo-2,3-dihydro-1,5-benzothiazepin-3-yl] ethanoate
  • acetic acid [(2S,3S)-5-(2-dimethylaminoethyl)-4-keto-2-(4-methoxyphenyl)-2,3-dihydro-1,5-benzothiazepin-3-yl] ester
  • Diltiazem (free base)
  • O-DesMethyl DiltiazeM, HydrobroMide (Cis - RaceMic)
  • 1,5-benzothiazepin-4(5h)-one,3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihy
  • 1,5-benzothiazepin-4(5h)-one,3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihy
  • 5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate
  • d-cis-diltiazem
  • (+)-CIS-DILTIAZEM
  • DILTIAZEM
  • (2S)-5-[2-(Dimethylamino)ethyl]-2α,3α-dihydro-3β-acetyloxy-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
  • [(3S,4S)-6-(2-dimethylaminoethyl)-3-(4-methoxyphenyl)-5-oxo-2-thia-6-azabicyclo[5.4.0]undeca-7,9,11-trien-4-yl] acetate
  • 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-2-(dimethylamino)ethyl-2,3-dihydro-2-(4-methoxyphenyl)-, (2S,3S)-
  • 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, (2S-cis)-
  • Adizem XL
  • Coras
  • d-Diltiazem
  • TILDIEM300LP
  • Diltiazem (base and/or unspecified salts)
  • 3-amino-1,2,4-triazole-1-carboxylic acid ethyl ester
  • high quality Diltiazem
  • High purity diltiazem/diltiazem hydrochloride
  • Diltiazem HCl salt
  • Diltiazem USP/EP/BP
  • NSC 7324
  • NSC7324
  • NSC-7324
  • (2S,3S)-5-(2-(diMethylaMino)ethyl)-2-(4-Methoxyphenyl)-4-oxo-2,3,4,5-tetrahydrobenzo[b][1,4]thiazepin-3-yl acetate
  • DILTIAZEN
  • Dilthiazem
  • (2S-Cis)-3-(Acetyloxy)-5-[2-dimethylamino)ethyl]-2,3-dihydro-2-(4methoxy phenyl)- 1,5benzothiazepin-4(5H)-one D
  • Diltiazem HCl (2S,3S)-5-[2-(Dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo- 2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate hydrochloride
  • Diltiazem fandachem
  • 42399-41-7
  • 43299-41-7
  • C22H26N2O4S
  • 42399-41-7
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