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Diltiazem hydrochloride

Diltiazem hydrochloride Struktur
33286-22-5
CAS-Nr.
33286-22-5
Bezeichnung:
Diltiazem hydrochloride
Englisch Name:
Diltiazem hydrochloride
Synonyma:
DILTIAZEM HCL;DILTHIAZEM HYDROCHLORIDE;Tiazac;Sprix;Acuvail;cardizem;herbesser;Dilacor XR;Diltiazem Hydrochlorid;(2S,cis)-3-(Acetyloxy)-5-[(2-dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one Hydrochloride
CBNumber:
CB7302994
Summenformel:
C22H27ClN2O4S
Molgewicht:
450.98
MOL-Datei:
33286-22-5.mol

Diltiazem hydrochloride Eigenschaften

Schmelzpunkt:
212-214 °C
alpha 
D24 +98.3 ± 1.4° (c = 1.002 in methanol)
Dichte
1.30 g/cm3
Brechungsindex
118 ° (C=1, H2O)
Flammpunkt:
2℃
storage temp. 
2-8°C
L?slichkeit
Freely soluble in water, in methanol and in methylene chloride, slightly soluble in anhydrous ethanol.
Aggregatzustand
Powder
Farbe
White to off-white
PH
pH (10g/l, 25℃) : 4.3~5.3
Wasserl?slichkeit
soluble
Merck 
13,3226
BRN 
4228706
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
CAS Datenbank
33286-22-5(CAS DataBase Reference)
EPA chemische Informationen
1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, hydrochloride (1:1), (2S,3S)- (33286-22-5)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn,Xi,F
R-S?tze: 22-40-36/37/38-36-20/21/22-11
S-S?tze: 36-45-36/37-26-16
RIDADR  3249
WGK Germany  3
RTECS-Nr. DL0310000
8-10
HazardClass  6.1(b)
PackingGroup  III
HS Code  29349990
Toxizit?t LD50 in male, female mice, male, female rats (mg/kg): 61, 58, 38, 39 i.v.; 260, 280, 520, 550 s.c.; 740, 640, 560, 610 orally (Nagao, 1972)
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit

Diltiazem hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

Chemische Eigenschaften

Diltiazem hydrochloride is a white to off-white crystalline powder with a bitter taste. It is soluble in water, methanol, and chloroform. It has a molecular weight of 450.98. Diltiazem hydrochloride injection is a clear, colorless, sterile, nonpyrogenic solution. It has a pH range of 3.7 to 4.1.

Verwenden

An antianginal, antihypertensive. Regulates Calcium release from intracellular stores in neutrophils

Definition

ChEBI: Diltiazem hydrochloride is a hydrochloride salt resulting from the reaction of equimolar amounts of diltiazem and hydrogen chloride. A calcium-channel blocker and vasodilator, it is used in the management of angina pectoris and hypertension. It has a role as an antihypertensive agent, a vasodilator agent and a calcium channel blocker. It contains a diltiazem(1+). It is an enantiomer of an ent-diltiazem hydrochloride.

Allgemeine Beschreibung

Diltiazem hydrochloride is a calcium ion cellular influx inhibitor. It was developed and introduced inJapan as a cardiovascular agent to treat angina pectoris. Itwas observed to dilate peripheral arteries and arterioles. Thedrug increases myocardial oxygen supply by relieving coronaryartery spasm and reduces myocardial oxygen demandby decreasing heart rate and reducing overload. Diltiazemhydrochloride is used in patients with variant angina. Thedrug has electrophysiological properties similar to those ofverapamil and is used in clinically similar treatment conditionsas an antiarrhythmic agent, but it is less potent.
The drug is absorbed rapidly and almost completely fromthe digestive tract. It reaches peak plasma levels within 1hour after administration in gelatin capsules. Oral formulationson the market are sustained-release preparations providingpeak plasma levels 3 to 4 hours after administration.

Biologische Aktivit?t

Antihypertensive and cardioprotective agent; an inhibitor of L-type Ca 2+ channels.

Mode of action

Diltiazem Hydrochloride is a benzothiazepine calcium channel blocking agent. Diltiazem hydrochloride inhibits the transmembrane influx of extracellular calcium ions into select myocardial and vascular smooth muscle cells, causing dilatation of coronary and systemic arteries and decreasing myocardial contractility. Because of its vasodilatory activity, this agent has been shown to improve the microcirculation in some tumors, thereby potentially improving the delivery of antineoplastic agents to tumor cells.

Diltiazem hydrochloride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Diltiazem hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 542)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shanghai Jinhuan Chemical CO.,LTD.
+86-21-52210535 +8613162045318
sales@jinhchem.com China 331 58
Hebei Weibang Biotechnology Co., Ltd
+8617732866630
bess@weibangbio.com China 18151 58
Suzhou Sanyi Polymer Chemical Technology Co., Ltd.
+8615571922873
15571922873@163.com China 102 58
Henan Bao Enluo International TradeCo.,LTD
+86-17331933971 +86-17331933971
deasea125996@gmail.com China 2472 58
Guangzhou Tengyue Chemical Co., Ltd.
+86-86-18148706580 +8618826483838
evan@tyvovo.com China 148 58
Anhui Ruihan Technology Co., Ltd
+8617756083858
daisy@anhuiruihan.com China 973 58
Shaanxi Franta Biotechnology Co., Ltd
+86-13082019107 +86-13082019107
admin@flanderff.com China 244 58
Hebei Mojin Biotechnology Co.,Ltd
+86-15028179902
angelia@hbmojin.com China 1176 58
Hebei Ganmiao New material Technology Co., LTD
+86-17332992504 +86-17332992504
sales8@hbganmiao.com China 300 58
Fuzhou Lista Biotechnology Co.,Ltd

sallychris2021@gmail.com China 75 58

33286-22-5(Diltiazem hydrochloride)Verwandte Suche:


  • (2S-cis)-3-acetoxy-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one monohydrochloride
  • 1,5-benzothiazepin-4(5h)-one,2,3-dihydro-3-(acetyloxy)-5-(2-(dimethylamino)eth
  • 2,3-dihydro-3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2-(4-methoxyphenyl)-5-benzothiazepin-4(5h)-one
  • altiazem
  • anginyl
  • angizem
  • masdil
  • monohydrochloride,cis-(+)-yl)-2-(4-methoxyphenyl)
  • tildiem
  • Adizem
  • Zilde
  • 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-2-(dimethylamino)ethyl-2,3-dihydro-2-(4-methoxyphenyl)-, monohydrochloride, (2S,3S)-
  • (+)-cis-diltiazem hydrochloride
  • (2s,3s)-(+)-cis-3-acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5h)-one hydrochloride
  • DILTIAZEMHYDROCHLORIDE,USP
  • (S,S)-Diltiazem hydrochloride
  • 1,5-Benzothiazepin-4(5H)-one, 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-, monohydrochloride, (2S-cis)-
  • Blocalcin 60
  • Cardizem CD
  • Cardizem SR
  • Citizem
  • Cormax
  • d-cis-3-Acetoxy-2,3-dihydro-5-[2-(dimethylamino)ethyl]-2-(p-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride
  • d-cis-Diltiazem hydrochloride
  • Deltazen
  • Dilacor
  • Diladel
  • Dilrene
  • Dilzene
  • Kardil
  • RG 83606
  • Diltiazem HCl USP
  • (+)-cis-3-(Acetyloxy)-5-(2-(dimethylamino)ethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)one monohydrochloride
  • Zilden
  • 1,5-Benzothiazepin-4(5H)-one, 2,3-dihydro-3-(acetyloxy)-5-(2-(dimethylamino)ethyl)-2-(4- methoxyphenyl)-, monohydrochloride, cis-(+)
  • Calnurs
  • Clarute
  • Cohlen
  • Coroherser
  • Diltiazem hydrochloride,99%
  • CRD-401, (2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride
  • (+)-cis-Diltiazem hydrochloride,(2S,3S)-(+)-cis-3-Acetoxy-5-(2-dimethylaminoethyl)-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride, CRD-401
  • Diltiazem Hydrochloride (200 mg)
  • Acetonitrile ( Test Diltiazem HCl, 1.0 mg/mL as free base)
  • Dilthiazem hydrochlo
  • Diltiazem HCl, (2S-cis)-3-(Acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one hydrochloride
  • Angipress
  • (2S,3S)-(+)-CIS-3-(ACETOXY)-5-(2-DIMETHYLAMINOETHYL)-2,3-DIHYDRO-2-(4-METHOXYPHENYL)-1,5-
  • 1,5-Benzothiazepin-4(5H)-one,3-(acetyloxy)-5-[2-(diMethylaMino)ethyl]-2,3-dihydro-2-(4-Methoxyphenyl)-,hydrochloride (1:1), (2S,3S)-
  • RG 83606 HCl
  • (2S,3S)- 3-(acetyloxy)-5-[2-(dimethylamino)ethyl]-2,3-dihydro-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one,hydrochloride (1:1)
  • Diltiazem hydrochloride solution
  • britiazim
  • bruzem
  • calcicard
  • dilpral
  • diltiazemchloridrate
  • dilzem
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