????
|
|
???? ??
- ???
- 212 °C (decomp)
- ?? ?
- 594.4±50.0 °C(Predicted)
- ??
- 1.26±0.1 g/cm3(Predicted)
- ?? ??
- -20°C Freezer
- ???
- ?????(?? ???), DMSO(?? ???), ???(?? ???)
- ?? ?? (pKa)
- pKa 7.70 (Uncertain)
- ??? ??
- ??
- ??? ??
- ??? ??
- ??
- ???? ?????
- CAS ??????
- 42399-41-7(CAS DataBase Reference)
??
| ?? ?? ??? | 42399-41-7(Hazardous Substances Data) |
|---|
???? C??? ??, ??, ??
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Diltiazem is a potent vasodilator compound. Antihypertensive.??
ChEBI: A 5-[2-(dimethylamino)ethyl]-2-(4-methoxyphenyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl acetate in which both stereocentres have S configuration. A calcium-channel blocker and vasodilator, it is used as the hydrochloride in the m nagement of angina pectoris and hypertension.Mechanism of action
Diltiazem reduces the transmembrane influx of calcium ions into cells of cardiac muscle and smooth musculature of vessels. It causes dilation of coronary and peripheral vessels, increases coronary blood flow, and prevents development of coronary artery spasms. It lowers elevated arterial pressure and reduces tachycardia.Clinical Use
The antiarrhythmic actions and uses of diltiazem are similar to those of verapamil. Diltiazem is effective in controlling the ventricular rate in patients with atrial flutter or atrial fibrillation.???? ?? ?? ? ???
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2-???????
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??????(??)
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Diltiazem hydrochloride
Ethyl 4-methoxycinnamate
(αS,βS)-β-[(2-AMinophenyl)thio]-α-hydroxy-4-MethoxybenzenepropanoicAcid??????
????????
(2S-cis)-(+)-2,3-Dihydro-3-hydroxy-2-(4-methoxyphenyl)-1,5-benzothiazepin-4(5H)-one
4-???????
2-????????? ??? ?????
?? ??
???? ?? ??
???( 154)?? ??
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