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Clidiniumbromid

Clidinium bromide Struktur
3485-62-9
CAS-Nr.
3485-62-9
Bezeichnung:
Clidiniumbromid
Englisch Name:
Clidinium bromide
Synonyma:
Clidinium;QUARZAN;Ro-3773;AV54315;AV 54315;AV-54315;RO-2-3773;quarzanbromide;CLIDINIUM BROMIDE;Clidinium Brimide
CBNumber:
CB5419496
Summenformel:
C22H26BrNO3
Molgewicht:
432.35
MOL-Datei:
3485-62-9.mol

Clidiniumbromid Eigenschaften

Schmelzpunkt:
240-241°C
storage temp. 
Inert atmosphere,Room Temperature
L?slichkeit
DMSO (Slightly), Methanol (Slightly, Sonicated), Water (Slightly)
Aggregatzustand
Solid
Farbe
White to Off-White
CAS Datenbank
3485-62-9(CAS DataBase Reference)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
S-S?tze: 36
RIDADR  3249
WGK Germany  3
RTECS-Nr. VD6125000
HazardClass  6.1(b)
PackingGroup  III
HS Code  2933399090
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Clidiniumbromid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.

S-S?tze Betriebsanweisung:

S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Clidinium is a gastrointestinal muscarinic receptor antagonist (Ki = 3 nM against [3H]quinuclidinyl benzilate binding in rat colonic enterocytes). Administration of clidinium, at a dose of 1 mg/kg, slows intestinal transit and induces constipation in mice. This clidinium-induced constipation induces serum hyperammonemia and decreases clonic, myoclonic, and tonic seizure thresholds in a murine pentylenetetrazole-induced epilepsy model.

Chemische Eigenschaften

White Crystalline Solid

Verwenden

Clidinium inhibits muscarinic action of acetylcholine on postganglionic parasympathetic effector regions. It is used for treating stomach ulcers.

Definition

ChEBI: The bromide salt of clinidium. It is used for the symptomatic treatment of peptic ulcer disease and also to help relieve abdominal or stomach spasms or cramps due to colicky abdominal pain, diverticulitis, and irritable bowel syndrome.

Allgemeine Beschreibung

Clidinium bromide, 3-hydroxy-1-methylquinuclidinium bromide benzilate (Quarzan),is a white or nearly white, almost odorless, crystalline powderthat is optically inactive. It is soluble in water and alcohol butonly very slightly soluble in ether and benzene.

Clinical Use

This anticholinergic agent is marketed alone and in combinationwith the minor tranquilizer chlordiazepoxide (Librium)in a product known as Librax. The rationale of the combinationfor the treatment of GI complaints is the use of an anxiety-reducing agent together with an anticholinergic agent,based on the recognized contribution of anxiety to the developmentof the diseased condition. It is suggested for pepticulcer, hyperchlorhydria, ulcerative or spastic colon, anxietystates with GI manifestations, nervous stomach, irritable orspastic colon, and others. Clidinium bromide is contraindicatedin glaucoma and other conditions that may be aggravatedby the parasympatholytic action, such as prostatic hypertrophyin elderly men, which could lead to urinary retention.

Synthese

Clidinium, 3-benzyloyloxy-1-methylcynuclidinium bromide (14.1.19), is synthesized by reacting 3-hydroxycynuclidine (14.1.17) with the of benzilic acid chloride producing the ester (14.1.18), which if further alkylated at the nitrogen atom by methylbromide, giving clidinium (14.1.19) [16].

Synthesis_3485-62-9

Clidiniumbromid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Clidiniumbromid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 127)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Shaanxi Dideu Medichem Co. Ltd
+86-029-81138252 +86-18789408387
1057@dideu.com China 3959 58
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32957 60
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29880 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15352 58
Baoji Guokang Bio-Technology Co., Ltd.
0917-3909592 13892490616
gksales1@gk-bio.com China 9312 58
Baoji Guokang Healthchem co.,ltd
+8615604608665 15604608665
dominicguo@gk-bio.com CHINA 9414 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739
info@dycnchem.com China 52849 58

3485-62-9(Clidiniumbromid)Verwandte Suche:


  • RO-2-3773
  • quinuclidinolmethylbromide,benzilate
  • 3-[(Hydroxyphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2,2,2]octane Bromide, Ro-2-3773, Quarzan
  • (1-Methyl-1-azoniabicyclo[2.2.2]octan-8-yl) 2-hydroxy-2,2-diphenylacetate bromide
  • 1-Azoniabicyclo[2.2.2]octane, 3-[(hydroxydiphenylacetyl)oxy]-1-methyl-, bromide
  • 3-[(Hydroxydiphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane bromide
  • Ro-3773
  • 3-[(Hydroxydiphenylacetyl)oxy]-1-methyl-1-azoniabicyclo[2.2.2]octane
  • Clidinium Brimide
  • Clidinium Bromide (500 mg)
  • Clidinium Bromide (2 g)
  • 3-[(2-hydroxy-2,2-diphenylacetyl)oxy]-1-Methyl-1-azabicyclo[2.2.2]octan-1-iuM broMide
  • 1-methyl-3-benzil-oxyloxy-quinuclidiniumbromide
  • 3-((hydroxydiphenylacetyl)oxy)-1-methyl-1-azoniabicyclo(2.2.2)octanbromi
  • CLIDINIUM BROMIDE
  • 3-[(HYDROXYPHENYLACETYL)OXY]-1-METHYL-1-AZONIABICYCLO[2,2,2]OCTANE BROMIDE
  • 3-HYDROXY-1-METHYLQUINUCLIDINIUM BROMIDE BENZILATE
  • 3-(2,2-diphenyl-2-hydroxyethanoyloxy)-quinuclidiniumbromide
  • 3-(benziloyloxy)-1-methylquinuclidiniumbromide
  • benzilicacid,esterwith3-hydroxy-1-methylquinuclidinium
  • quarzanbromide
  • quinuclidinium,3-hydroxy-1-methyl-,bromide,benzilate
  • Clidinium iodide D3
  • 2-hydroxy-2,2-diphenylacetic acid (1-methyl-1-azoniabicyclo[2.2.2]octan-3-yl) ester bromide
  • 3-(2-Hydroxy-2,2-diphenylacetoxy)-1-methylquinuclidin-1-ium bromide
  • Clidinium BromideQ: What is Clidinium Bromide Q: What is the CAS Number of Clidinium Bromide Q: What is the storage condition of Clidinium Bromide Q: What are the applications of Clidinium Bromide
  • Clidinium-D5 bromideQ: What is Clidinium-D5 bromide Q: What is the CAS Number of Clidinium-D5 bromide
  • Clidinium Bromide (1135000)
  • AV 54315
  • AV54315
  • AV-54315
  • QUARZAN
  • Clidinium
  • 3485-62-9
  • C22H26NO3Br
  • C22H26BO3Rn
  • C22H26BrNO3
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  • CI - CL
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